The data set after preprocessing, which resulted in 29 inptus. Original data set was obtained in literature survey with 298 inputs. Input: chemical descriptors and characteristics of 8 PLGA microparicles formulation. Output: mean particle size of PLGA microparticles Number of attributes 29, single output.
Literature survey yielded 68 formulations of PLGA microspheres with protein as active pharmaceuticla ingridient. In vitro release profiles as well as formulation characteristics and composition were derived from articles. Chemical descriptors were obtained using Marvin ChemAxon software (cxcalc plugin). The final data base consisted of 298 inputs and single output mean particle size.
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Iwata M et al. In vitro and in vivo release properties of brilliant blue and tumour necrosis factor-alpha (TNF-alpha) from poly(D,L-lactic-co-glycolic acid) multiphase microspheres. J Microencapsul. 1999, 16(6), 777-792.
Jiang HL et al. Improvement of protein loading and modulation of protein release from poly(lactide-co-glycolide) microspheres by complexation of proteins with polyanions. J Microencapsul. 2004, 21(6), 615-624
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Brodbeck KJ et al. Sustained release of human growth hormone from PLGA solution depots. Pharm Res. 2009, 16(12), 1825-1829.
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