oc.gentwostage.bdry: Two-stage boundary operating characteristics

In gen2stage: Generalized Two-Stage Designs for Phase II Single-Arm Studies

Description

Calculates the operating characteristics of a two-stage boundary based on the R function oc.twostage.bdry.

Usage

oc.gentwostage.bdry(pu, pa, r1, n1, r, n)

Arguments

pu	unacceptable response rate
pa	response rate that is desirable
r1	first stage threshold to declare treatment undesirable
n1	first stage sample size
r	overall threshold to declare treatment undesirable
n	total sample size

Value

oc.gentwostage.bdry returns the type I and II error rates as well as the probability of early temination and expected sample size under pu for a specific boundary.

References

Kim S and Wong WK. Phase II Two-Stage Single-Arm Clinical Trials for Testing Toxicity Levels. Commun Stat Appl Methods. 2019 Mar;26(2):163-173. https://www.ncbi.nlm.nih.gov/pubmed/31106162.

See Also

gen2simon

Examples

  # Optimal two-stage safety design with pu (p0) = 0.33 vs. pa (p1) = 0.20
  oc.gentwostage.bdry(0.33, 0.20, 8, 26, 22, 85)

  # Optimal two-stage efficacy design with pu (p0) = 0.67 vs. pa (p1) = 0.80
  oc.gentwostage.bdry(0.67, 0.80, 18, 26, 63, 85)

gen2stage documentation built on June 3, 2019, 5:04 p.m.