DLRule: Drop the loser rule

View source: R/groupRAR_functions.R

DLRuleR Documentation

Drop the loser rule

Description

Simulating drop the loser rule procedure with two-sided hypothesis testing in a clinical trial context.

Usage

DLRule(k, p, ssn, Y0 = NULL, nsim = 2000, alpha = 0.05)

Arguments

k

a positive integer. The value specifies the number of treatment groups involved in a clinical trial. (k = 2)

p

a positive vector of length equals to k. The values specify the true success rates for the various treatments, and these rates are used to generate data for simulations.

ssn

a positive integer. The value specifies the total number of participants involved in each round of the simulation.

Y0

A vector of length k, specifying the initial probability of allocating a patient to each group. For instance, if Y0 = c(1, 1, 1), the initial probabilities are calculated as Y0 / sum(Y0). When Y0 is NULL, the initial urn will be set as If Y0 is NULL, then Y0 is set to a vector of length k, with all values equal to 1 by default.

nsim

a positive integer. The value specifies the total number of simulations, with a default value of 2000.

alpha

A number between 0 and 1. The value represents the predetermined level of significance that defines the probability threshold for rejecting the null hypothesis, with a default value of 0.05.

Details

Drop the loser rule can be describe as follows: An urn contains three types of balls (A, B, 0) initially. Balls of types A and B represent treatments A and B, balls of 0 type are immigration balls. If A (or B) is drawn, then treatment A (or B) is assigned to the subject and the response is observed. If the observed response is a failure, then the ball is not replaced, else replaced. If an immigration ball (type 0) is drawn, no treatment is assigned, and the ball is returned to the urn together with one A and one B ball.

Value

name

The name of procedure.

parameter

The true parameters used to do the simulations.

assignment

The randomization sequence.

propotion

Average allocation porpotion for each of treatment groups.

failRate

The proportion of individuals who do not achieve the expected outcome in each simulation, on average.

pwClac

The probability of the study to detect a significant difference or effect if it truly exists.

k

Number of arms involved in the trial.

References

Ivanova, A. (2003). A play-the-winner-type urn design with reduced variability. Metrika, 58, 1-13.

Examples

## a simple use
dl.res = DLRule(k = 2, p = c(0.7, 0.8), ssn = 400, Y0 = NULL, nsim = 200, alpha = 0.05)

## view the output
dl.res


  ## view all simulation settings
  dl.res$name
  dl.res$parameter
  dl.res$k

  ## View the simulations results
  dl.res$propotion
  dl.res$failRate
  dl.res$pwCalc
  dl.res$assignment
  

grouprar documentation built on June 22, 2024, 7:18 p.m.

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