gwas2crispr-package: gwas2crispr package-level imports

In gwas2crispr: GWAS-to-CRISPR Data Pipeline for High-Throughput SNP Target Extraction

gwas2crispr package-level imports

Description

Provides a reproducible pipeline to conduct genome-wide association studies (GWAS) and extract single-nucleotide polymorphisms (SNPs) for a human trait or disease. Given aggregated GWAS dataset(s) and a user-defined significance threshold, the package retrieves significant SNPs from the GWAS Catalog using supported trait identifiers, annotates their gene context, and can write a harmonised metadata table in comma-separated values (CSV) format, genomic intervals in the Browser Extensible Data (BED) format, and sequences in the FASTA (text-based sequence) format with user-defined flanking regions for clustered regularly interspaced short palindromic repeats (CRISPR) guide design. The existing efo_id argument is retained for backward compatibility. The package prepares computational artifacts for downstream workflows; it does not perform biological causality testing, clinical interpretation, therapeutic design, or wet-lab validation. For details on the resources and methods see: Buniello et al. (2019) \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1093/nar/gky1120")}; Sollis et al. (2023) \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1093/nar/gkac1010")}; Jinek et al. (2012) \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1126/science.1225829")}.

Author(s)

Maintainer: Othman S. I. Mohammed [e-mail]

Other contributors:

• LEOPARD.LY LTD [copyright holder]

See Also

Useful links:

• https://github.com/leopard0ly/gwas2crispr

• Report bugs at https://github.com/leopard0ly/gwas2crispr/issues

gwas2crispr documentation built on June 2, 2026, 9:06 a.m.