aft.bhm: Posterior of Bayesian hierarchical model (BHM)

In hdbayes: Bayesian Analysis of Generalized Linear Models with Historical Data

Posterior of Bayesian hierarchical model (BHM)

Description

Sample from the posterior distribution of an accelerated failure time (AFT) model using the Bayesian hierarchical model (BHM).

Usage

aft.bhm(
  formula,
  data.list,
  dist = "weibull",
  meta.mean.mean = NULL,
  meta.mean.sd = NULL,
  meta.sd.mean = NULL,
  meta.sd.sd = NULL,
  scale.mean = NULL,
  scale.sd = NULL,
  get.loglik = FALSE,
  iter_warmup = 1000,
  iter_sampling = 1000,
  chains = 4,
  ...
)

Arguments

formula	a two-sided formula giving the relationship between the response variable and covariates. The response is a survival object as returned by the survival::Surv(time, event) function, where event is a binary indicator for event (0 = no event, 1 = event has occurred). The type of censoring is assumed to be right-censoring.
data.list	a list of data.frames. The first element in the list is the current data, and the rest are the historical data sets. For fitting accelerated failure time (AFT) models, all historical data sets will be stacked into one historical data set.
dist	a character indicating the distribution of survival times. Currently, dist can be one of the following values: "weibull", "lognormal", or "loglogistic". Defaults to "weibull".
meta.mean.mean	a scalar or a vector whose dimension is equal to the number of regression coefficients giving the means for the normal hyperpriors on the mean hyperparameters of regression coefficients. If a scalar is provided, meta.mean.mean will be a vector of repeated elements of the given scalar. Defaults to a vector of 0s.
meta.mean.sd	a scalar or a vector whose dimension is equal to the number of regression coefficients giving the sds for the normal hyperpriors on the mean hyperparameters of regression coefficients. If a scalar is provided, same as for meta.mean.mean. Defaults to a vector of 10s.
meta.sd.mean	a scalar or a vector whose dimension is equal to the number of regression coefficients giving the means for the half-normal hyperpriors on the sd hyperparameters of regression coefficients. If a scalar is provided, same as for meta.mean.mean. Defaults to a vector of 0s.
meta.sd.sd	a scalar or a vector whose dimension is equal to the number of regression coefficients giving the sds for the half-normal hyperpriors on the sd hyperparameters of regression coefficients. If a scalar is provided, same as for meta.mean.mean. Defaults to a vector of 1s.
scale.mean	location parameter for the half-normal prior on the scale parameters of current and historical data models. Defaults to 0.
scale.sd	scale parameter for the half-normal prior on the scale parameters of current and historical data models. Defaults to 10.
get.loglik	whether to generate log-likelihood matrix. Defaults to FALSE.
iter_warmup	number of warmup iterations to run per chain. Defaults to 1000. See the argument iter_warmup in sample() method in cmdstanr package.
iter_sampling	number of post-warmup iterations to run per chain. Defaults to 1000. See the argument iter_sampling in sample() method in cmdstanr package.
chains	number of Markov chains to run. Defaults to 4. See the argument chains in sample() method in cmdstanr package.
...	arguments passed to sample() method in cmdstanr package (e.g., seed, refresh, init).

Details

The Bayesian hierarchical model (BHM) assumes that the regression coefficients for the historical and current data are different, but are correlated through a common distribution, whose hyperparameters (i.e., mean and standard deviation (sd) (the covariance matrix is assumed to have a diagonal structure)) are treated as random. The number of regression coefficients for the current data is assumed to be the same as that for the historical data.

The hyperpriors on the mean and the sd hyperparameters are independent normal and independent half-normal distributions, respectively. The scale parameters for both current and historical data models are assumed to be independent and identically distributed, each assigned a half-normal prior.

Value

The function returns an object of class draws_df containing posterior samples. The object has two attributes:

data

a list of variables specified in the data block of the Stan program

model

a character string indicating the model name

Examples

if (instantiate::stan_cmdstan_exists()) {
  if(requireNamespace("survival")){
    library(survival)
    data(E1684)
    data(E1690)
    ## take subset for speed purposes
    E1684 = E1684[1:100, ]
    E1690 = E1690[1:50, ]
    ## replace 0 failure times with 0.50 days
    E1684$failtime[E1684$failtime == 0] = 0.50/365.25
    E1690$failtime[E1690$failtime == 0] = 0.50/365.25
    E1684$cage = as.numeric(scale(E1684$age))
    E1690$cage = as.numeric(scale(E1690$age))
    data_list = list(currdata = E1690, histdata = E1684)
    aft.bhm(
      formula = survival::Surv(failtime, failcens) ~ treatment + sex + cage + node_bin,
      data.list = data_list,
      dist = "weibull",
      chains = 1, iter_warmup = 500, iter_sampling = 1000
    )
  }
}

hdbayes documentation built on Nov. 21, 2025, 1:07 a.m.