heritEWAS-package: heritEWAS: Identify heritable DNA methylation marks from...

In heritEWAS: Identify Heritable Methylation Marks

Description

heritEWAS implements the statistical method of (Joo et al., 2018) to efficiently scan the genome for DNA methylation marks that are heritable. This method looks for Mendelian patterns of inheritance at methylation sites, and is based only on the relationship structure of (large) families and on the methylation data of some individuals within these families. In particular, genotype data is not required.

Details

The methylation data will typically come from an epigenome-wide association study (EWAS), and heritEWAS is optimised for such data, e.g. the most time-consuming part of the calculation is performed once, then the output of this calculation is re-used for all methylation sites. However, the code can also be run on methylation data at a single genomic location.

For each methylation site, the code computes a measure of heritability called Delta l. It is not clear what relationship exists between this measure and classical measures of heritability, such as those estimated by twin studies.

The methods implemented in this package are described briefly in ML_estimates and fully in (Joo et al., 2018).

Author(s)

Maintainer: Kevin Wong [e-mail]

Authors:

• James Dowty [e-mail]

heritEWAS documentation built on July 1, 2020, 6:02 p.m.