egfr.bis.cr_cys: Calculate eGFR by the Berlin Initiative Study (BIS2)...

In kidney.epi: Kidney-Related Functions for Clinical and Epidemiological Research

Calculate eGFR by the Berlin Initiative Study (BIS2) creatinine-cystatin C-based equation

Description

Calculate eGFR by the Berlin Initiative Study (BIS2) creatinine-cystatin C-based equation

Usage

egfr.bis.cr_cys(
  creatinine,
  cystatin,
  age,
  sex,
  creatinine_units = "micromol/l",
  cystatin_units = "mg/l",
  label_sex_male = c("Male", 1),
  label_sex_female = c("Female", 0),
  max_age = 100
)

Arguments

creatinine	Numeric vector. Serum creatinine, could be expressed in "micromol/L", "mmol/L" or "mg/dL". Units of measurement should be defined in variable creatinine_units (if not defined explicitly by user, the default value is "micromol/L").
cystatin	Numeric vector. Serum cystatin, could be expressed in "mg/L" or "nanomol/L". Units of measurement should be defined in variable cystatin_units (if not defined explicitly by user, the default value is "mg/L").
age	Numeric vector. Age, in years.
sex	Vector. The value of variable refers to the parameters label_sex_male and label_sex_female.
creatinine_units	Character string. Units in which serum creatinne is expressed. Could be one of the following: "micromol/L", "mmol/L" or "mg/dL".
cystatin_units	Character string. Units in which serum cystatin is expressed. Could be one of the following: "mg/L" or "nanomol/L"
label_sex_male	List. Label(s) for definition(s) of male sex.
label_sex_female	List. Label(s) for definition(s) of female sex.
max_age	Numeric. Maximal age suitable for the equation application, in years. By default is 100 years, but change this value in case you would like to apply equation to older persons.

Details

Calculate estimated glomerular filtration rate (eGFR) by the Berlin Initiative Study (BIS2) creatinine-cystatin C-based equation.

Reference to the equation: Schaeffner ES, Ebert N, Delanaye P et al. Two novel equations to estimate kidney function in persons aged 70 years or older. Ann Intern Med 2012; 157: 471–481 doi: 10.7326/0003-4819-157-7-201210020-00003.

Citation: Bikbov B. kidney.epi: Kidney-Related Functions for Clinical and Epidemiological Research. Scientific-Tools.Org, https://Scientific-Tools.Org. DOI: 10.32614/CRAN.package.kidney.epi

Value

numeric eGFR expressed in ml/min/1.73m².

Author(s)

Programming: Boris Bikbov https://www.linkedin.com/in/boris-bikbov.

Examples

# for a single patient
egfr.bis.cr_cys (creatinine = 1.4, cystatin = 1.0, age = 80,
   sex = "Male", creatinine_units = "mg/dl",
   cystatin_units = "mg/L")
# for a dataset - see vignettes for details
# egfr.bis.cr_cys (creatinine = dta$scr, cystatin = dta$cys, 
#   age = dta$age, sex = dta$sex, 
#   creatinine_units = "mg/dl", cystatin_units = "mg/l")

kidney.epi documentation built on June 8, 2025, 10:54 a.m.