The core of this 'Rcpp' based package is several functions to estimate the baseline hazard, frailty variance, and fixed effect parameter for a discretetime shared frailty model with random effects. The functions are designed to analyze grouped timetoevent data accounting for family structure of related individuals (i.e., trios). The core functions include two processes: (1) evaluate the multivariable integration to compute the exact proportional hazards model based likelihood and (2) estimate the desired parameters using maximum likelihood estimation. The integration is evaluated by the 'Cuhre' algorithm from the 'Cuba' library (Hahn, T., Cubaa library for multidimensional numerical integration, Comput. Phys. Commun. 168, 2005, 7895
Package details 


Author  Jiaxing Lin, Alexander Sibley, Tracy Truong, Nancy Cox, Eileen Dolan, Yu Jiang, Janice McCarthy, Andrew Allen, Kouros Owzar, Zhiguo Li 
Date of publication  20170221 00:03:26 
Maintainer  Jiaxing Lin <[email protected]> 
License  GPL (>= 2) 
Version  1.0.3 
Package repository  View on CRAN 
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