The core of this 'Rcpp' based package is several functions to estimate the baseline hazard, frailty variance, and fixed effect parameter for a discrete-time shared frailty model with random effects. The functions are designed to analyze grouped time-to-event data accounting for family structure of related individuals (i.e., trios). The core functions include two processes: (1) evaluate the multivariable integration to compute the exact proportional hazards model based likelihood and (2) estimate the desired parameters using maximum likelihood estimation. The integration is evaluated by the 'Cuhre' algorithm from the 'Cuba' library (Hahn, T., Cuba-a library for multidimensional numerical integration, Comput. Phys. Commun. 168, 2005, 78-95
|Author||Jiaxing Lin, Alexander Sibley, Tracy Truong, Nancy Cox, Eileen Dolan, Yu Jiang, Janice McCarthy, Andrew Allen, Kouros Owzar, Zhiguo Li|
|Date of publication||2017-02-21 00:03:26|
|Maintainer||Jiaxing Lin <[email protected]>|
|License||GPL (>= 2)|
|Package repository||View on CRAN|
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