lclGWAS: Efficient Estimation of Discrete-Time Multivariate Frailty Model Using Exact Likelihood Function for Grouped Survival Data
Version 1.0.3

The core of this 'Rcpp' based package is several functions to estimate the baseline hazard, frailty variance, and fixed effect parameter for a discrete-time shared frailty model with random effects. The functions are designed to analyze grouped time-to-event data accounting for family structure of related individuals (i.e., trios). The core functions include two processes: (1) evaluate the multivariable integration to compute the exact proportional hazards model based likelihood and (2) estimate the desired parameters using maximum likelihood estimation. The integration is evaluated by the 'Cuhre' algorithm from the 'Cuba' library (Hahn, T., Cuba-a library for multidimensional numerical integration, Comput. Phys. Commun. 168, 2005, 78-95 ), and the source files of the 'Cuhre' function are included in this package. The maximization process is carried out using Brent's algorithm, with the 'C++' code file from John Burkardt and John Denker (Brent, R.,Algorithms for Minimization without Derivatives, Dover, 2002, ISBN 0-486-41998-3).

AuthorJiaxing Lin, Alexander Sibley, Tracy Truong, Nancy Cox, Eileen Dolan, Yu Jiang, Janice McCarthy, Andrew Allen, Kouros Owzar, Zhiguo Li
Date of publication2017-02-21 00:03:26
MaintainerJiaxing Lin <jiaxing.lin@duke.edu>
LicenseGPL (>= 2)
Version1.0.3
Package repositoryView on CRAN
InstallationInstall the latest version of this package by entering the following in R:
install.packages("lclGWAS")

Getting started

Package overview

Popular man pages

alphaEst: Estimate the Interval Baseline Survival Rates for...
betaEst: Estimate the Fixed Effect Parameter for Discrete-Time...
lclGWAS-package: Efficient Estimation of Multivariate Frailty Model Using...
varEst: Estimate the Frailty Variance for Discrete-Time Multivariate...
See all...

All man pages Function index File listing

Man pages

alphaEst: Estimate the Interval Baseline Survival Rates for...
betaEst: Estimate the Fixed Effect Parameter for Discrete-Time...
lclGWAS-package: Efficient Estimation of Multivariate Frailty Model Using...
varEst: Estimate the Frailty Variance for Discrete-Time Multivariate...

Functions

alphaEst Man page Source code
betaEst Man page Source code
lclGWAS Man page
lclGWAS-package Man page
varEst Man page Source code

Files

inst
inst/doc
inst/doc/lclGWAS.Rnw
inst/doc/lclGWAS.pdf
inst/doc/lclGWAS.R
src
src/decl.h
src/Makevars
src/alphaEst.cpp
src/common.h
src/fam_LLBeta.h
src/varEst.cpp
src/integrand.h
src/likelihood_ind.h
src/stddecl.h
src/fam_LLVar.h
src/config.h
src/ChiSquare.h
src/betaEst.cpp
src/fminbr.h
src/famSize.h
src/util.h
src/debug.h
src/cuba.h
src/global.h
src/Erf.h
src/fminbr.cpp
src/Cuhre.c
src/Rule.h
src/Makevars.win
src/init.c
src/RcppExports.cpp
src/Integrate.h
NAMESPACE
NEWS
R
R/RcppExports.R
vignettes
vignettes/lclGWAS.Rnw
MD5
build
build/vignette.rds
DESCRIPTION
man
man/varEst.Rd
man/alphaEst.Rd
man/lclGWAS-package.Rd
man/betaEst.Rd
lclGWAS documentation built on May 20, 2017, 3:32 a.m.