polyps: RCT of Sulindac for Polyp Prevention in Familial Adenomatous...
In medicaldata: Data Package for Medical Datasets
Description
Usage
Format
Details
Source
Description
Results of a randomized, placebo-controlled trial of sulindac in the reduction of colonic polyps in Familial Adenomatous Polyposis (FAP) (more details available below the variable definitions).
Usage
1
Format
A data frame with 22 observations and 7 variables
- participant_id
id number for each participant; type: character
- sex
participant sex, levels: female, male; type: factor
- age
age in years; type: numeric
- baseline
number of colonic polyps at baseline; type: numeric
- treatment
treatment assignment, levels: sulindac, placebo; type: factor
- number3m
number of colonic polyps at 3 months; type: numeric
- number12m
number of colonic polyps at 12 months; type: numeric
Details
FAP is an inherited condition caused by mutations in the APC (Adenomatous Polyposis Coli) gene that leads to early and frequent formation of precancerous polyps of the colon at a young age, and invariably leads to the development of colon cancer at a young age.
Early, frequent surveillance colonoscopy and polyp removal is helpful, but this study examined whether there is a beneficial effect of preventive medical therapy with the nonsteroidal pain reliever, sulindac, versus placebo in a RCT vs placebo in 22 participants, with polyp number measured (via colonoscopy) at baseline, 3 months, and 12 months after starting the study drug. Note that one subject did not return for the 12 month colonoscopy.
Source
This data set is from a study published in 1993 in the New England Journal of Medicine,
F. M. Giardiello, S. R. Hamilton, A. J. Krush, S. Piantadosi, L. M. Hylind, P. Celano, S. V. Booker, C. R. Robinson and G. J. A. Offerhaus (1993), Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. New England Journal of Medicine, 328(18), 1313-1316.
This dataset is derived from and improved upon from the HSAUR package.
medicaldata documentation built on Aug. 16, 2021, 9:08 a.m.
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Description Usage Format Details Source
Description
Results of a randomized, placebo-controlled trial of sulindac in the reduction of colonic polyps in Familial Adenomatous Polyposis (FAP) (more details available below the variable definitions).
Usage
1 |
Format
A data frame with 22 observations and 7 variables
- participant_id
id number for each participant; type: character
- sex
participant sex, levels: female, male; type: factor
- age
age in years; type: numeric
- baseline
number of colonic polyps at baseline; type: numeric
- treatment
treatment assignment, levels: sulindac, placebo; type: factor
- number3m
number of colonic polyps at 3 months; type: numeric
- number12m
number of colonic polyps at 12 months; type: numeric
Details
FAP is an inherited condition caused by mutations in the APC (Adenomatous Polyposis Coli) gene that leads to early and frequent formation of precancerous polyps of the colon at a young age, and invariably leads to the development of colon cancer at a young age.
Early, frequent surveillance colonoscopy and polyp removal is helpful, but this study examined whether there is a beneficial effect of preventive medical therapy with the nonsteroidal pain reliever, sulindac, versus placebo in a RCT vs placebo in 22 participants, with polyp number measured (via colonoscopy) at baseline, 3 months, and 12 months after starting the study drug. Note that one subject did not return for the 12 month colonoscopy.
Source
This data set is from a study published in 1993 in the New England Journal of Medicine,
F. M. Giardiello, S. R. Hamilton, A. J. Krush, S. Piantadosi, L. M. Hylind, P. Celano, S. V. Booker, C. R. Robinson and G. J. A. Offerhaus (1993), Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. New England Journal of Medicine, 328(18), 1313-1316.
This dataset is derived from and improved upon from the HSAUR package.
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