pbc: Mayo Clinic primary biliary cirrhosis data
In merlin: Mixed Effects Regression for Linear, Non-Linear and User-Defined Models

Description Usage Format Note Source References

This data is from the Mayo Clinic trial in primary biliary cirrhosis (PBC) of the liver conducted between 1974 and 1984. A total of 424 PBC patients, referred to Mayo Clinic during that ten-year interval met eligibility criteria for the randomized placebo controlled trial of the drug D-penicillamine, but only the first 312 cases in the data set participated in the randomized trial. Therefore, the data here are for the 312 patients with largely complete data.

1
2
3

data(pbc)

data(pbc.merlin)

A data frame with 1945 observations on the following 20 variables:

id: patients identifier; in total there are 312 patients.
years: number of years between registration and the earlier of death, transplantation, or study analysis time.
status: a factor with levels alive, transplanted and dead.
drug: a factor with levels placebo and D-penicil.
age: at registration in years.
sex: a factor with levels male and female.
year: number of years between enrollment and this visit date, remaining values on the line of data refer to this visit.
ascites: a factor with levels No and Yes.
hepatomegaly: a factor with levels No and Yes.
spiders: a factor with levels No and Yes.
edema: a factor with levels No edema (i.e. no edema and no diuretic therapy for edema), edema no diuretics (i.e. edema present without diuretics, or edema resolved by diuretics), and edema despite diuretics (i.e. edema despite diuretic therapy).
serBilir: serum bilirubin in mg/dl.
serChol: serum cholesterol in mg/dl.
albumin: albumin in mg/dl.
alkaline: alkaline phosphatase in U/liter.
SGOT: SGOT in U/ml.
platelets: platelets per cubic ml/1000.
prothrombin: prothrombin time in seconds.
histologic: histologic stage of disease.
status2: a numeric vector with the value 1 denoting if the patient was dead, and 0 if the patient was alive or transplanted.