IPDNa: A simulated Individual Patient Data (IPD) meta-analysis with...

Description Usage Format Details Source References Examples

Description

This dataset is a simulated version of an IPD meta-analysis consisting of 28 studies focusing on risk factors in acute heart failure (GREAT, 2013). Each study includes a list of patient characteristics and potential risk factors. Each of them is incomplete, leading to sporadically missing values (Resche-Rigon, et al 2013). In addition, some variables have been collected on some studies only, leading to systematically missing values. More details on the original dataset are provided in Audigier et al. (2018). To mimic the real data, a general location model has been fitted on each study (Schafer, 1997). Then, each study has been generated according to the estimated parameters. Finally, missing values have been allocated similarly to the original dataset.

Usage

1
data("IPDNa")

Format

A data frame with 11685 observations on the following 10 variables.

centre

a numeric indexing the center where the study is conducted

gender

a factor with levels 0 1

bmi

a numeric vector indicating the body mass index

age

a numeric vector indicating the age

sbp

a numeric vector indicating the systolic blood pressure

dbp

a numeric vector indicating the diastolic blood pressure

hr

a numeric vector indicating the heart rate

lvef

a numeric vector indicating the ventricular ejection fraction

bnp

a numeric vector indicating the level of the brain natriuretic peptide biomarker

afib

a factor with levels 0 1 indicating the atrial fibrillation

Details

For more details, see Audigier et al. (2018)

Source

GREAT Network (2013). Managing acute heart failure in the ed - case studies from the acute heart failure academy. http://www.greatnetwork.org

References

Audigier, V., White, I. , Jolani ,S. Debray, T., Quartagno, M., Carpenter, J., van Buuren, S. and Resche-Rigon, M. Multiple imputation for multilevel data with continuous and binary variables (2018). Statistical Science. <doi:10.1214/18-STS646>.

Resche-Rigon, M., White, I. R., Bartlett, J., Peters, S., Thompson, S., and on behalf of the PROG-IMT Study Group (2013). Multiple imputation for handling systematically missing confounders in meta-analysis of individual participant data. Statistics in Medicine, 32(28):48904905. <doi:10.1002/sim.5894>

Schafer, J. L. (1997) Analysis of Incomplete Multivariate Data. Chapman \& Hall, Chapter 9.

Examples

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data(IPDNa)

#summary
summary(IPDNa)

#summary per study
by(IPDNa,IPDNa$centre,summary)

Example output

Loading required package: mice
     centre      gender        bmi              age              sbp       
 Min.   : 1.00   0:6916   Min.   : 10.86   Min.   : 18.00   Min.   : 22.0  
 1st Qu.:12.00   1:4769   1st Qu.: 23.34   1st Qu.: 60.00   1st Qu.:112.0  
 Median :16.00            Median : 26.72   Median : 70.00   Median :133.0  
 Mean   :15.24            Mean   : 27.31   Mean   : 70.46   Mean   :135.1  
 3rd Qu.:21.00            3rd Qu.: 30.58   3rd Qu.: 80.00   3rd Qu.:156.0  
 Max.   :28.00            Max.   :116.24   Max.   :176.00   Max.   :305.0  
                          NA's   :2426     NA's   :7        NA's   :407    
      dbp               hr             lvef            bnp           afib     
 Min.   :  6.00   Min.   : 27.0   Min.   :0.040   Min.   : 0.997   0   :7800  
 1st Qu.: 66.00   1st Qu.: 72.0   1st Qu.:0.270   1st Qu.: 2.558   1   :3335  
 Median : 79.00   Median : 86.0   Median :0.360   Median : 2.917   NA's: 550  
 Mean   : 78.59   Mean   : 90.5   Mean   :0.398   Mean   : 2.961              
 3rd Qu.: 91.00   3rd Qu.:105.0   3rd Qu.:0.480   3rd Qu.: 3.331              
 Max.   :163.00   Max.   :284.0   Max.   :2.260   Max.   :10.123              
 NA's   :423      NA's   :167                     NA's   :8909                
IPDNa$centre: 1
     centre  gender       bmi             age              sbp       
 Min.   :1   0:203   Min.   :15.11   Min.   : 50.00   Min.   : 71.0  
 1st Qu.:1   1:207   1st Qu.:24.26   1st Qu.: 64.00   1st Qu.:121.0  
 Median :1           Median :28.07   Median : 72.00   Median :142.0  
 Mean   :1           Mean   :28.49   Mean   : 72.72   Mean   :143.5  
 3rd Qu.:1           3rd Qu.:31.35   3rd Qu.: 79.00   3rd Qu.:163.0  
 Max.   :1           Max.   :48.18   Max.   :108.00   Max.   :247.0  
                     NA's   :148     NA's   :1        NA's   :4      
      dbp               hr              lvef             bnp          afib    
 Min.   : 16.00   Min.   : 30.00   Min.   :0.1100   Min.   :1.855   0   :323  
 1st Qu.: 68.00   1st Qu.: 74.00   1st Qu.:0.3200   1st Qu.:2.671   1   : 86  
 Median : 82.00   Median : 88.00   Median :0.4150   Median :2.934   NA's:  1  
 Mean   : 81.38   Mean   : 92.11   Mean   :0.4539   Mean   :3.008             
 3rd Qu.: 95.00   3rd Qu.:108.00   3rd Qu.:0.5600   3rd Qu.:3.343             
 Max.   :142.00   Max.   :194.00   Max.   :1.2300   Max.   :4.421             
 NA's   :8        NA's   :12                        NA's   :235               
------------------------------------------------------------ 
IPDNa$centre: 2
     centre  gender       bmi             age              sbp       
 Min.   :2   0:319   Min.   :14.98   Min.   : 36.00   Min.   : 67.0  
 1st Qu.:2   1:248   1st Qu.:24.26   1st Qu.: 58.00   1st Qu.:125.8  
 Median :2           Median :28.08   Median : 68.00   Median :147.0  
 Mean   :2           Mean   :29.06   Mean   : 70.48   Mean   :146.8  
 3rd Qu.:2           3rd Qu.:33.22   3rd Qu.: 81.00   3rd Qu.:167.0  
 Max.   :2           Max.   :53.54   Max.   :148.00   Max.   :242.0  
                     NA's   :105                      NA's   :11     
      dbp               hr              lvef             bnp        afib   
 Min.   : 29.00   Min.   : 35.00   Min.   :0.0600   Min.   :1.845   0:433  
 1st Qu.: 66.00   1st Qu.: 68.00   1st Qu.:0.2100   1st Qu.:2.612   1:134  
 Median : 79.00   Median : 80.00   Median :0.3000   Median :2.908          
 Mean   : 78.68   Mean   : 82.29   Mean   :0.3489   Mean   :2.948          
 3rd Qu.: 92.00   3rd Qu.: 94.00   3rd Qu.:0.4300   3rd Qu.:3.248          
 Max.   :136.00   Max.   :229.00   Max.   :1.6900   Max.   :5.053          
 NA's   :17       NA's   :6                         NA's   :57             
------------------------------------------------------------ 
IPDNa$centre: 3
     centre  gender       bmi             age              sbp       
 Min.   :3   0:150   Min.   :16.42   Min.   : 43.00   Min.   : 70.0  
 1st Qu.:3   1: 60   1st Qu.:24.94   1st Qu.: 61.25   1st Qu.:109.0  
 Median :3           Median :27.76   Median : 69.00   Median :130.0  
 Mean   :3           Mean   :28.27   Mean   : 71.95   Mean   :129.2  
 3rd Qu.:3           3rd Qu.:31.58   3rd Qu.: 80.75   3rd Qu.:147.5  
 Max.   :3           Max.   :42.85   Max.   :134.00   Max.   :221.0  
                     NA's   :90                       NA's   :3      
      dbp               hr              lvef             bnp          afib    
 Min.   : 42.00   Min.   : 44.00   Min.   :0.0800   Min.   :2.036   0   :  0  
 1st Qu.: 68.00   1st Qu.: 71.00   1st Qu.:0.2400   1st Qu.:2.860   1   :  0  
 Median : 76.00   Median : 83.00   Median :0.3300   Median :3.276   NA's:210  
 Mean   : 75.41   Mean   : 85.55   Mean   :0.3670   Mean   :3.325             
 3rd Qu.: 84.00   3rd Qu.: 99.00   3rd Qu.:0.4375   3rd Qu.:3.713             
 Max.   :103.00   Max.   :160.00   Max.   :1.1600   Max.   :5.258             
 NA's   :4        NA's   :3                                                   
------------------------------------------------------------ 
IPDNa$centre: 4
     centre  gender       bmi             age              sbp       
 Min.   :4   0:232   Min.   :14.39   Min.   : 41.00   Min.   : 57.0  
 1st Qu.:4   1:143   1st Qu.:23.18   1st Qu.: 66.00   1st Qu.:122.2  
 Median :4           Median :25.78   Median : 74.00   Median :141.0  
 Mean   :4           Mean   :26.72   Mean   : 73.83   Mean   :141.7  
 3rd Qu.:4           3rd Qu.:29.69   3rd Qu.: 81.00   3rd Qu.:159.0  
 Max.   :4           Max.   :52.27   Max.   :106.00   Max.   :264.0  
                     NA's   :9                        NA's   :5      
      dbp               hr              lvef             bnp          afib    
 Min.   : 29.00   Min.   : 40.00   Min.   :0.1000   Min.   :1.658   0   :135  
 1st Qu.: 76.00   1st Qu.: 76.00   1st Qu.:0.2900   1st Qu.:2.636   1   : 84  
 Median : 88.50   Median : 90.00   Median :0.3900   Median :2.905   NA's:156  
 Mean   : 87.65   Mean   : 94.49   Mean   :0.4193   Mean   :2.938             
 3rd Qu.:100.00   3rd Qu.:109.00   3rd Qu.:0.5000   3rd Qu.:3.241             
 Max.   :163.00   Max.   :202.00   Max.   :1.3600   Max.   :4.771             
 NA's   :5        NA's   :9                         NA's   :15                
------------------------------------------------------------ 
IPDNa$centre: 5
     centre  gender      bmi             age              sbp       
 Min.   :5   0:59   Min.   :17.74   Min.   : 41.00   Min.   : 86.0  
 1st Qu.:5   1:48   1st Qu.:26.01   1st Qu.: 62.00   1st Qu.:134.5  
 Median :5          Median :27.85   Median : 70.00   Median :153.0  
 Mean   :5          Mean   :28.71   Mean   : 74.23   Mean   :153.3  
 3rd Qu.:5          3rd Qu.:31.70   3rd Qu.: 82.00   3rd Qu.:162.5  
 Max.   :5          Max.   :39.11   Max.   :176.00   Max.   :246.0  
                    NA's   :1                                       
      dbp               hr             lvef             bnp      afib  
 Min.   : 45.00   Min.   : 45.0   Min.   :0.2100   Min.   : NA   0:48  
 1st Qu.: 74.00   1st Qu.: 83.0   1st Qu.:0.3600   1st Qu.: NA   1:59  
 Median : 87.00   Median :101.0   Median :0.4700   Median : NA         
 Mean   : 86.73   Mean   :105.0   Mean   :0.4848   Mean   :NaN         
 3rd Qu.: 99.50   3rd Qu.:124.5   3rd Qu.:0.5800   3rd Qu.: NA         
 Max.   :131.00   Max.   :198.0   Max.   :1.2000   Max.   : NA         
                                                   NA's   :107         
------------------------------------------------------------ 
IPDNa$centre: 6
     centre  gender       bmi           age              sbp           dbp     
 Min.   :6   0:150   Min.   : NA   Min.   : 44.00   Min.   : NA   Min.   : NA  
 1st Qu.:6   1:117   1st Qu.: NA   1st Qu.: 66.00   1st Qu.: NA   1st Qu.: NA  
 Median :6           Median : NA   Median : 72.00   Median : NA   Median : NA  
 Mean   :6           Mean   :NaN   Mean   : 74.09   Mean   :NaN   Mean   :NaN  
 3rd Qu.:6           3rd Qu.: NA   3rd Qu.: 82.00   3rd Qu.: NA   3rd Qu.: NA  
 Max.   :6           Max.   : NA   Max.   :125.00   Max.   : NA   Max.   : NA  
                     NA's   :267                    NA's   :267   NA's   :267  
       hr              lvef             bnp      afib   
 Min.   : 35.00   Min.   :0.1400   Min.   : NA   0:160  
 1st Qu.: 74.00   1st Qu.:0.2900   1st Qu.: NA   1:107  
 Median : 93.00   Median :0.3700   Median : NA          
 Mean   : 97.37   Mean   :0.4131   Mean   :NaN          
 3rd Qu.:116.00   3rd Qu.:0.5100   3rd Qu.: NA          
 Max.   :284.00   Max.   :0.9300   Max.   : NA          
 NA's   :1                         NA's   :267          
------------------------------------------------------------ 
IPDNa$centre: 7
     centre  gender       bmi             age             sbp       
 Min.   :7   0: 97   Min.   :16.66   Min.   : 36.0   Min.   : 55.0  
 1st Qu.:7   1:106   1st Qu.:23.11   1st Qu.: 60.0   1st Qu.:120.8  
 Median :7           Median :27.01   Median : 70.0   Median :138.0  
 Mean   :7           Mean   :27.33   Mean   : 71.4   Mean   :140.6  
 3rd Qu.:7           3rd Qu.:30.79   3rd Qu.: 81.0   3rd Qu.:159.2  
 Max.   :7           Max.   :42.73   Max.   :125.0   Max.   :238.0  
                     NA's   :1                       NA's   :3      
      dbp               hr              lvef             bnp        afib   
 Min.   : 25.00   Min.   : 40.00   Min.   :0.1500   Min.   :1.165   0:127  
 1st Qu.: 64.00   1st Qu.: 66.00   1st Qu.:0.3350   1st Qu.:1.972   1: 76  
 Median : 78.00   Median : 80.00   Median :0.4400   Median :2.387          
 Mean   : 76.78   Mean   : 85.27   Mean   :0.4937   Mean   :2.463          
 3rd Qu.: 88.50   3rd Qu.: 98.25   3rd Qu.:0.6000   3rd Qu.:2.825          
 Max.   :129.00   Max.   :207.00   Max.   :1.4000   Max.   :6.454          
 NA's   :4        NA's   :3                         NA's   :1              
------------------------------------------------------------ 
IPDNa$centre: 8
     centre  gender       bmi             age             sbp     
 Min.   :8   0:235   Min.   :17.05   Min.   : 37.0   Min.   : 50  
 1st Qu.:8   1:119   1st Qu.:23.41   1st Qu.: 58.0   1st Qu.:106  
 Median :8           Median :27.21   Median : 67.0   Median :125  
 Mean   :8           Mean   :27.43   Mean   : 70.1   Mean   :129  
 3rd Qu.:8           3rd Qu.:30.76   3rd Qu.: 80.0   3rd Qu.:151  
 Max.   :8           Max.   :47.71   Max.   :153.0   Max.   :233  
                     NA's   :157     NA's   :5       NA's   :57   
      dbp               hr              lvef             bnp          afib    
 Min.   :  6.00   Min.   : 39.00   Min.   :0.0900   Min.   :2.168   0   :149  
 1st Qu.: 62.75   1st Qu.: 69.00   1st Qu.:0.2500   1st Qu.:2.756   1   :127  
 Median : 75.00   Median : 85.00   Median :0.3400   Median :3.080   NA's: 78  
 Mean   : 76.04   Mean   : 86.81   Mean   :0.3775   Mean   :3.099             
 3rd Qu.: 89.00   3rd Qu.:100.00   3rd Qu.:0.4675   3rd Qu.:3.407             
 Max.   :129.00   Max.   :180.00   Max.   :1.2500   Max.   :4.391             
 NA's   :58       NA's   :67                        NA's   :44                
------------------------------------------------------------ 
IPDNa$centre: 9
     centre  gender       bmi             age             sbp       
 Min.   :9   0:126   Min.   :16.79   Min.   : 43.0   Min.   : 42.0  
 1st Qu.:9   1: 11   1st Qu.:23.17   1st Qu.: 61.0   1st Qu.:108.0  
 Median :9           Median :25.57   Median : 72.0   Median :131.0  
 Mean   :9           Mean   :26.14   Mean   : 73.3   Mean   :134.9  
 3rd Qu.:9           3rd Qu.:28.80   3rd Qu.: 83.0   3rd Qu.:155.0  
 Max.   :9           Max.   :38.70   Max.   :115.0   Max.   :305.0  
                     NA's   :1                                      
      dbp               hr              lvef             bnp        afib  
 Min.   : 19.00   Min.   : 47.00   Min.   :0.1500   Min.   :1.958   0:69  
 1st Qu.: 64.00   1st Qu.: 82.00   1st Qu.:0.3100   1st Qu.:2.630   1:68  
 Median : 79.00   Median : 94.00   Median :0.3700   Median :2.888         
 Mean   : 77.86   Mean   : 99.04   Mean   :0.3797   Mean   :2.927         
 3rd Qu.: 91.00   3rd Qu.:116.00   3rd Qu.:0.4500   3rd Qu.:3.187         
 Max.   :125.00   Max.   :188.00   Max.   :0.8000   Max.   :4.099         
                                                                          
------------------------------------------------------------ 
IPDNa$centre: 10
     centre   gender      bmi           age              sbp       
 Min.   :10   0:25   Min.   : NA   Min.   : 29.00   Min.   : 50.0  
 1st Qu.:10   1:23   1st Qu.: NA   1st Qu.: 39.00   1st Qu.:112.8  
 Median :10          Median : NA   Median : 54.00   Median :142.5  
 Mean   :10          Mean   :NaN   Mean   : 61.42   Mean   :147.5  
 3rd Qu.:10          3rd Qu.: NA   3rd Qu.: 71.50   3rd Qu.:181.2  
 Max.   :10          Max.   : NA   Max.   :154.00   Max.   :269.0  
                     NA's   :48                                    
      dbp               hr             lvef             bnp      afib  
 Min.   : 39.00   Min.   : 60.0   Min.   :0.2100   Min.   : NA   0:36  
 1st Qu.: 72.00   1st Qu.: 89.5   1st Qu.:0.3150   1st Qu.: NA   1:12  
 Median : 85.00   Median : 99.0   Median :0.5050   Median : NA         
 Mean   : 84.69   Mean   :105.0   Mean   :0.5773   Mean   :NaN         
 3rd Qu.:100.00   3rd Qu.:117.8   3rd Qu.:0.6575   3rd Qu.: NA         
 Max.   :131.00   Max.   :175.0   Max.   :2.2600   Max.   : NA         
                  NA's   :2                        NA's   :48          
------------------------------------------------------------ 
IPDNa$centre: 11
     centre   gender       bmi             age              sbp       
 Min.   :11   0:140   Min.   :16.79   Min.   : 39.00   Min.   : 54.0  
 1st Qu.:11   1: 68   1st Qu.:24.16   1st Qu.: 55.00   1st Qu.:101.0  
 Median :11           Median :27.66   Median : 65.00   Median :118.5  
 Mean   :11           Mean   :27.25   Mean   : 67.02   Mean   :123.3  
 3rd Qu.:11           3rd Qu.:30.16   3rd Qu.: 76.00   3rd Qu.:142.2  
 Max.   :11           Max.   :38.00   Max.   :162.00   Max.   :224.0  
                      NA's   :49                                      
      dbp              hr             lvef             bnp      afib   
 Min.   : 32.0   Min.   : 32.0   Min.   :0.0900   Min.   : NA   0:160  
 1st Qu.: 61.0   1st Qu.: 71.0   1st Qu.:0.2500   1st Qu.: NA   1: 48  
 Median : 74.0   Median : 86.0   Median :0.3500   Median : NA          
 Mean   : 74.4   Mean   : 87.2   Mean   :0.3715   Mean   :NaN          
 3rd Qu.: 88.0   3rd Qu.: 99.0   3rd Qu.:0.4400   3rd Qu.: NA          
 Max.   :114.0   Max.   :159.0   Max.   :1.4400   Max.   : NA          
 NA's   :1                                        NA's   :208          
------------------------------------------------------------ 
IPDNa$centre: 12
     centre   gender       bmi             age              sbp       
 Min.   :12   0:424   Min.   :15.52   Min.   : 41.00   Min.   : 47.0  
 1st Qu.:12   1:198   1st Qu.:23.95   1st Qu.: 61.00   1st Qu.:107.0  
 Median :12           Median :27.12   Median : 69.00   Median :126.0  
 Mean   :12           Mean   :27.50   Mean   : 71.05   Mean   :127.1  
 3rd Qu.:12           3rd Qu.:30.49   3rd Qu.: 79.00   3rd Qu.:147.0  
 Max.   :12           Max.   :47.07   Max.   :141.00   Max.   :261.0  
                      NA's   :167                      NA's   :3      
      dbp               hr              lvef             bnp      afib   
 Min.   : 21.00   Min.   : 40.00   Min.   :0.1300   Min.   : NA   0:346  
 1st Qu.: 65.00   1st Qu.: 73.00   1st Qu.:0.2600   1st Qu.: NA   1:276  
 Median : 76.00   Median : 85.00   Median :0.3500   Median : NA          
 Mean   : 75.08   Mean   : 88.98   Mean   :0.3741   Mean   :NaN          
 3rd Qu.: 86.00   3rd Qu.:100.00   3rd Qu.:0.4500   3rd Qu.: NA          
 Max.   :130.00   Max.   :166.00   Max.   :1.1300   Max.   : NA          
 NA's   :3        NA's   :9                         NA's   :622          
------------------------------------------------------------ 
IPDNa$centre: 13
     centre   gender      bmi             age             sbp       
 Min.   :13   0:36   Min.   :17.37   Min.   :26.00   Min.   : 76.0  
 1st Qu.:13   1:42   1st Qu.:22.69   1st Qu.:45.00   1st Qu.:103.0  
 Median :13          Median :25.90   Median :50.50   Median :113.0  
 Mean   :13          Mean   :27.79   Mean   :52.58   Mean   :115.5  
 3rd Qu.:13          3rd Qu.:32.14   3rd Qu.:57.50   3rd Qu.:126.2  
 Max.   :13          Max.   :48.77   Max.   :96.00   Max.   :161.0  
                     NA's   :47                                     
      dbp               hr              lvef             bnp        afib   
 Min.   : 42.00   Min.   : 50.00   Min.   :0.1100   Min.   : NA   0   : 0  
 1st Qu.: 63.00   1st Qu.: 70.50   1st Qu.:0.2025   1st Qu.: NA   1   : 0  
 Median : 70.50   Median : 82.50   Median :0.2550   Median : NA   NA's:78  
 Mean   : 73.09   Mean   : 84.69   Mean   :0.2728   Mean   :NaN            
 3rd Qu.: 82.00   3rd Qu.: 97.75   3rd Qu.:0.3300   3rd Qu.: NA            
 Max.   :108.00   Max.   :156.00   Max.   :0.6000   Max.   : NA            
                                                    NA's   :78             
------------------------------------------------------------ 
IPDNa$centre: 14
     centre   gender       bmi             age             sbp       
 Min.   :14   0:333   Min.   :16.49   Min.   : 53.0   Min.   : 59.0  
 1st Qu.:14   1:337   1st Qu.:23.66   1st Qu.: 71.0   1st Qu.:122.0  
 Median :14           Median :27.04   Median : 77.0   Median :141.0  
 Mean   :14           Mean   :27.43   Mean   : 78.1   Mean   :142.1  
 3rd Qu.:14           3rd Qu.:30.28   3rd Qu.: 85.0   3rd Qu.:160.0  
 Max.   :14           Max.   :45.61   Max.   :111.0   Max.   :240.0  
                      NA's   :514     NA's   :1       NA's   :6      
      dbp               hr              lvef             bnp        afib    
 Min.   : 19.00   Min.   : 40.00   Min.   :0.1500   Min.   : NA   0   :302  
 1st Qu.: 68.00   1st Qu.: 70.00   1st Qu.:0.3500   1st Qu.: NA   1   :367  
 Median : 80.00   Median : 83.00   Median :0.4600   Median : NA   NA's:  1  
 Mean   : 79.28   Mean   : 86.27   Mean   :0.4789   Mean   :NaN             
 3rd Qu.: 91.00   3rd Qu.: 99.75   3rd Qu.:0.5800   3rd Qu.: NA             
 Max.   :126.00   Max.   :174.00   Max.   :1.2200   Max.   : NA             
 NA's   :6        NA's   :12                        NA's   :670             
------------------------------------------------------------ 
IPDNa$centre: 15
     centre   gender       bmi             age              sbp       
 Min.   :15   0:490   Min.   :13.88   Min.   : 29.00   Min.   : 57.0  
 1st Qu.:15   1:510   1st Qu.:20.43   1st Qu.: 57.00   1st Qu.:111.0  
 Median :15           Median :22.62   Median : 67.00   Median :130.0  
 Mean   :15           Mean   :22.96   Mean   : 68.92   Mean   :131.4  
 3rd Qu.:15           3rd Qu.:25.20   3rd Qu.: 78.00   3rd Qu.:151.2  
 Max.   :15           Max.   :36.33   Max.   :152.00   Max.   :230.0  
                      NA's   :130                      NA's   :16     
      dbp               hr              lvef             bnp          afib    
 Min.   : 18.00   Min.   : 37.00   Min.   :0.1000   Min.   :1.524   0   :803  
 1st Qu.: 65.00   1st Qu.: 73.00   1st Qu.:0.2600   1st Qu.:2.325   1   :194  
 Median : 79.00   Median : 89.00   Median :0.3500   Median :2.803   NA's:  3  
 Mean   : 78.53   Mean   : 94.07   Mean   :0.3759   Mean   :2.904             
 3rd Qu.: 91.00   3rd Qu.:111.00   3rd Qu.:0.4500   3rd Qu.:3.405             
 Max.   :146.00   Max.   :249.00   Max.   :1.6900   Max.   :5.299             
 NA's   :17       NA's   :20                        NA's   :817               
------------------------------------------------------------ 
IPDNa$centre: 16
     centre   gender       bmi             age              sbp       
 Min.   :16   0:798   Min.   :12.48   Min.   : 18.00   Min.   : 56.0  
 1st Qu.:16   1:295   1st Qu.:21.02   1st Qu.: 42.00   1st Qu.:103.0  
 Median :16           Median :23.41   Median : 53.00   Median :117.0  
 Mean   :16           Mean   :23.87   Mean   : 56.91   Mean   :117.5  
 3rd Qu.:16           3rd Qu.:26.28   3rd Qu.: 67.00   3rd Qu.:131.0  
 Max.   :16           Max.   :41.99   Max.   :147.00   Max.   :185.0  
                                                                      
      dbp               hr              lvef             bnp       afib   
 Min.   : 33.00   Min.   : 40.00   Min.   :0.1100   Min.   : NA    0:932  
 1st Qu.: 61.00   1st Qu.: 68.00   1st Qu.:0.3000   1st Qu.: NA    1:161  
 Median : 70.00   Median : 78.00   Median :0.3900   Median : NA           
 Mean   : 70.23   Mean   : 80.13   Mean   :0.4146   Mean   :NaN           
 3rd Qu.: 79.00   3rd Qu.: 91.00   3rd Qu.:0.5000   3rd Qu.: NA           
 Max.   :110.00   Max.   :156.00   Max.   :1.2900   Max.   : NA           
                                                    NA's   :1093          
------------------------------------------------------------ 
IPDNa$centre: 17
     centre   gender      bmi              age              sbp       
 Min.   :17   0:9    Min.   : 10.86   Min.   : 56.00   Min.   : 86.0  
 1st Qu.:17   1:9    1st Qu.: 26.96   1st Qu.: 59.75   1st Qu.:151.2  
 Median :17          Median : 38.58   Median : 69.00   Median :170.5  
 Mean   :17          Mean   : 45.08   Mean   : 71.11   Mean   :166.8  
 3rd Qu.:17          3rd Qu.: 53.67   3rd Qu.: 74.50   3rd Qu.:195.5  
 Max.   :17          Max.   :116.24   Max.   :108.00   Max.   :227.0  
                     NA's   :1                                        
      dbp               hr              lvef             bnp          afib 
 Min.   : 47.00   Min.   : 27.00   Min.   :0.1300   Min.   : 0.9971   0:9  
 1st Qu.: 70.50   1st Qu.: 75.75   1st Qu.:0.3425   1st Qu.: 1.8052   1:9  
 Median : 88.50   Median : 91.50   Median :0.5100   Median : 2.6966        
 Mean   : 88.33   Mean   : 96.67   Mean   :0.6950   Mean   : 3.2260        
 3rd Qu.:107.75   3rd Qu.:104.00   3rd Qu.:0.8150   3rd Qu.: 3.4763        
 Max.   :120.00   Max.   :216.00   Max.   :1.8800   Max.   :10.1229        
                                                    NA's   :4              
------------------------------------------------------------ 
IPDNa$centre: 18
     centre   gender        bmi             age              sbp       
 Min.   :18   0:1103   Min.   :15.56   Min.   : 35.00   Min.   : 22.0  
 1st Qu.:18   1: 731   1st Qu.:24.91   1st Qu.: 61.00   1st Qu.:110.0  
 Median :18            Median :28.10   Median : 70.00   Median :135.0  
 Mean   :18            Mean   :28.52   Mean   : 71.07   Mean   :136.3  
 3rd Qu.:18            3rd Qu.:31.74   3rd Qu.: 80.00   3rd Qu.:160.0  
 Max.   :18            Max.   :49.80   Max.   :130.00   Max.   :278.0  
                       NA's   :357                      NA's   :11     
      dbp               hr           lvef             bnp          afib     
 Min.   : 14.00   Min.   : 29   Min.   :0.1100   Min.   :1.688   0   :1392  
 1st Qu.: 66.00   1st Qu.: 72   1st Qu.:0.2800   1st Qu.:2.420   1   : 435  
 Median : 79.00   Median : 88   Median :0.3700   Median :2.812   NA's:   7  
 Mean   : 79.38   Mean   : 93   Mean   :0.4032   Mean   :2.790              
 3rd Qu.: 93.00   3rd Qu.:109   3rd Qu.:0.4900   3rd Qu.:3.109              
 Max.   :152.00   Max.   :251   Max.   :1.5200   Max.   :4.365              
 NA's   :11       NA's   :6                      NA's   :1695               
------------------------------------------------------------ 
IPDNa$centre: 19
     centre   gender       bmi             age              sbp       
 Min.   :19   0:162   Min.   :15.40   Min.   : 42.00   Min.   : 61.0  
 1st Qu.:19   1:196   1st Qu.:24.49   1st Qu.: 65.00   1st Qu.:118.0  
 Median :19           Median :27.38   Median : 72.00   Median :140.0  
 Mean   :19           Mean   :28.10   Mean   : 73.33   Mean   :141.4  
 3rd Qu.:19           3rd Qu.:31.52   3rd Qu.: 80.00   3rd Qu.:163.0  
 Max.   :19           Max.   :50.25   Max.   :119.00   Max.   :244.0  
                      NA's   :26                                      
      dbp               hr              lvef             bnp        afib   
 Min.   : 37.00   Min.   : 29.00   Min.   :0.1100   Min.   :1.550   0:248  
 1st Qu.: 71.00   1st Qu.: 74.00   1st Qu.:0.2700   1st Qu.:2.180   1:110  
 Median : 82.00   Median : 91.50   Median :0.3600   Median :2.500          
 Mean   : 81.68   Mean   : 97.14   Mean   :0.3812   Mean   :2.376          
 3rd Qu.: 93.00   3rd Qu.:116.00   3rd Qu.:0.4600   3rd Qu.:2.696          
 Max.   :133.00   Max.   :250.00   Max.   :0.9800   Max.   :2.954          
                                                    NA's   :354            
------------------------------------------------------------ 
IPDNa$centre: 20
     centre   gender      bmi             age              sbp       
 Min.   :20   0:25   Min.   :21.66   Min.   : 54.00   Min.   : 72.0  
 1st Qu.:20   1:29   1st Qu.:26.31   1st Qu.: 69.00   1st Qu.:125.0  
 Median :20          Median :29.90   Median : 76.00   Median :157.0  
 Mean   :20          Mean   :29.46   Mean   : 76.57   Mean   :151.8  
 3rd Qu.:20          3rd Qu.:32.37   3rd Qu.: 83.50   3rd Qu.:179.0  
 Max.   :20          Max.   :42.69   Max.   :101.00   Max.   :223.0  
                     NA's   :3                        NA's   :1      
      dbp               hr              lvef             bnp        afib   
 Min.   : 55.00   Min.   : 56.00   Min.   :0.1200   Min.   : NA   0   :23  
 1st Qu.: 74.00   1st Qu.: 81.00   1st Qu.:0.2125   1st Qu.: NA   1   :30  
 Median : 89.00   Median : 91.00   Median :0.3400   Median : NA   NA's: 1  
 Mean   : 85.43   Mean   : 91.91   Mean   :0.3746   Mean   :NaN            
 3rd Qu.: 95.00   3rd Qu.:102.00   3rd Qu.:0.4775   3rd Qu.: NA            
 Max.   :120.00   Max.   :148.00   Max.   :1.2400   Max.   : NA            
 NA's   :1        NA's   :1                         NA's   :54             
------------------------------------------------------------ 
IPDNa$centre: 21
     centre   gender       bmi             age              sbp       
 Min.   :21   0:380   Min.   :15.52   Min.   : 33.00   Min.   : 39.0  
 1st Qu.:21   1:208   1st Qu.:23.80   1st Qu.: 62.75   1st Qu.:107.0  
 Median :21           Median :27.01   Median : 71.00   Median :128.0  
 Mean   :21           Mean   :27.86   Mean   : 72.63   Mean   :131.8  
 3rd Qu.:21           3rd Qu.:31.03   3rd Qu.: 80.00   3rd Qu.:155.0  
 Max.   :21           Max.   :47.76   Max.   :148.00   Max.   :246.0  
                      NA's   :59                       NA's   :2      
      dbp               hr              lvef             bnp          afib    
 Min.   : 17.00   Min.   : 39.00   Min.   :0.0400   Min.   :1.943   0   :423  
 1st Qu.: 65.00   1st Qu.: 73.00   1st Qu.:0.2000   1st Qu.:2.236   1   :164  
 Median : 78.00   Median : 87.00   Median :0.2900   Median :2.520   NA's:  1  
 Mean   : 77.45   Mean   : 89.99   Mean   :0.3371   Mean   :2.545             
 3rd Qu.: 89.00   3rd Qu.:103.00   3rd Qu.:0.4100   3rd Qu.:2.794             
 Max.   :122.00   Max.   :228.00   Max.   :1.5000   Max.   :3.429             
 NA's   :2                                          NA's   :571               
------------------------------------------------------------ 
IPDNa$centre: 22
     centre   gender       bmi             age              sbp       
 Min.   :22   0:307   Min.   :14.94   Min.   : 44.00   Min.   : 65.0  
 1st Qu.:22   1:344   1st Qu.:24.79   1st Qu.: 67.00   1st Qu.:121.0  
 Median :22           Median :28.00   Median : 74.00   Median :139.0  
 Mean   :22           Mean   :28.70   Mean   : 75.55   Mean   :141.1  
 3rd Qu.:22           3rd Qu.:32.22   3rd Qu.: 83.00   3rd Qu.:161.0  
 Max.   :22           Max.   :45.96   Max.   :123.00   Max.   :250.0  
                      NA's   :156                      NA's   :14     
      dbp               hr              lvef             bnp          afib    
 Min.   : 36.00   Min.   : 31.00   Min.   :0.1300   Min.   :1.611   0   :406  
 1st Qu.: 72.00   1st Qu.: 79.50   1st Qu.:0.3000   1st Qu.:2.495   1   :234  
 Median : 82.00   Median : 94.00   Median :0.3900   Median :2.825   NA's: 11  
 Mean   : 82.11   Mean   : 97.27   Mean   :0.4178   Mean   :2.905             
 3rd Qu.: 92.00   3rd Qu.:112.00   3rd Qu.:0.5000   3rd Qu.:3.290             
 Max.   :139.00   Max.   :227.00   Max.   :1.1600   Max.   :4.899             
 NA's   :15       NA's   :12                        NA's   :476               
------------------------------------------------------------ 
IPDNa$centre: 23
     centre   gender       bmi             age              sbp       
 Min.   :23   0:251   Min.   :19.35   Min.   : 46.00   Min.   : 57.0  
 1st Qu.:23   1:204   1st Qu.:26.83   1st Qu.: 66.00   1st Qu.:125.0  
 Median :23           Median :30.06   Median : 74.00   Median :145.0  
 Mean   :23           Mean   :30.77   Mean   : 74.76   Mean   :146.3  
 3rd Qu.:23           3rd Qu.:33.81   3rd Qu.: 82.00   3rd Qu.:166.0  
 Max.   :23           Max.   :53.67   Max.   :109.00   Max.   :242.0  
                      NA's   :7                                       
      dbp               hr              lvef             bnp          afib    
 Min.   : 25.00   Min.   : 41.00   Min.   :0.0900   Min.   :2.693   0   :240  
 1st Qu.: 74.00   1st Qu.: 76.00   1st Qu.:0.2600   1st Qu.:3.460   1   :214  
 Median : 85.00   Median : 90.00   Median :0.3300   Median :3.753   NA's:  1  
 Mean   : 84.86   Mean   : 95.97   Mean   :0.3553   Mean   :3.819             
 3rd Qu.: 96.00   3rd Qu.:110.00   3rd Qu.:0.4200   3rd Qu.:4.271             
 Max.   :137.00   Max.   :202.00   Max.   :0.8900   Max.   :5.389             
                  NA's   :1                         NA's   :393               
------------------------------------------------------------ 
IPDNa$centre: 24
     centre   gender       bmi             age              sbp       
 Min.   :24   0:206   Min.   :16.31   Min.   : 38.00   Min.   : 43.0  
 1st Qu.:24   1: 88   1st Qu.:23.99   1st Qu.: 56.00   1st Qu.:110.0  
 Median :24           Median :26.99   Median : 66.00   Median :136.0  
 Mean   :24           Mean   :27.53   Mean   : 67.32   Mean   :135.5  
 3rd Qu.:24           3rd Qu.:30.58   3rd Qu.: 77.00   3rd Qu.:159.0  
 Max.   :24           Max.   :44.42   Max.   :128.00   Max.   :257.0  
                      NA's   :13                       NA's   :1      
      dbp               hr              lvef             bnp        afib   
 Min.   : 16.00   Min.   : 37.00   Min.   :0.1100   Min.   :1.949   0:234  
 1st Qu.: 61.00   1st Qu.: 73.00   1st Qu.:0.2300   1st Qu.:2.470   1: 60  
 Median : 76.00   Median : 88.00   Median :0.3000   Median :2.911          
 Mean   : 74.45   Mean   : 93.09   Mean   :0.3323   Mean   :2.941          
 3rd Qu.: 90.00   3rd Qu.:110.00   3rd Qu.:0.4000   3rd Qu.:3.381          
 Max.   :117.00   Max.   :192.00   Max.   :1.0400   Max.   :4.187          
 NA's   :1        NA's   :1                         NA's   :237            
------------------------------------------------------------ 
IPDNa$centre: 25
     centre   gender       bmi             age              sbp       
 Min.   :25   0:286   Min.   :17.16   Min.   : 38.00   Min.   : 51.0  
 1st Qu.:25   1:111   1st Qu.:25.84   1st Qu.: 58.00   1st Qu.:112.0  
 Median :25           Median :28.94   Median : 66.00   Median :130.0  
 Mean   :25           Mean   :28.92   Mean   : 68.37   Mean   :132.9  
 3rd Qu.:25           3rd Qu.:31.84   3rd Qu.: 77.00   3rd Qu.:155.0  
 Max.   :25           Max.   :45.52   Max.   :126.00   Max.   :223.0  
                      NA's   :5                        NA's   :2      
      dbp               hr              lvef             bnp        afib    
 Min.   : 26.00   Min.   : 44.00   Min.   :0.1000   Min.   : NA   0   :325  
 1st Qu.: 66.00   1st Qu.: 74.00   1st Qu.:0.2700   1st Qu.: NA   1   : 70  
 Median : 80.00   Median : 87.00   Median :0.3400   Median : NA   NA's:  2  
 Mean   : 78.62   Mean   : 90.36   Mean   :0.3727   Mean   :NaN             
 3rd Qu.: 92.00   3rd Qu.:105.00   3rd Qu.:0.4500   3rd Qu.: NA             
 Max.   :138.00   Max.   :185.00   Max.   :1.1400   Max.   : NA             
 NA's   :2        NA's   :2                         NA's   :397             
------------------------------------------------------------ 
IPDNa$centre: 26
     centre   gender       bmi             age             sbp       
 Min.   :26   0:182   Min.   :17.16   Min.   : 35.0   Min.   : 62.0  
 1st Qu.:26   1:113   1st Qu.:24.31   1st Qu.: 59.0   1st Qu.:110.0  
 Median :26           Median :27.35   Median : 69.0   Median :131.0  
 Mean   :26           Mean   :27.99   Mean   : 70.9   Mean   :132.1  
 3rd Qu.:26           3rd Qu.:31.04   3rd Qu.: 80.0   3rd Qu.:151.5  
 Max.   :26           Max.   :46.67   Max.   :140.0   Max.   :215.0  
                      NA's   :33                                     
      dbp               hr             lvef             bnp        afib   
 Min.   : 32.00   Min.   : 32.0   Min.   :0.1400   Min.   :2.060   0:214  
 1st Qu.: 66.00   1st Qu.: 66.5   1st Qu.:0.2900   1st Qu.:2.679   1: 81  
 Median : 77.00   Median : 82.0   Median :0.4000   Median :3.029          
 Mean   : 77.74   Mean   : 88.7   Mean   :0.4344   Mean   :3.027          
 3rd Qu.: 90.00   3rd Qu.:108.5   3rd Qu.:0.5300   3rd Qu.:3.274          
 Max.   :125.00   Max.   :215.0   Max.   :1.1600   Max.   :4.543          
                                                   NA's   :194            
------------------------------------------------------------ 
IPDNa$centre: 27
     centre   gender       bmi             age              sbp       
 Min.   :27   0:143   Min.   :18.16   Min.   : 43.00   Min.   : 54.0  
 1st Qu.:27   1:160   1st Qu.:25.60   1st Qu.: 65.50   1st Qu.:122.0  
 Median :27           Median :28.26   Median : 74.00   Median :142.0  
 Mean   :27           Mean   :28.98   Mean   : 74.56   Mean   :145.9  
 3rd Qu.:27           3rd Qu.:31.53   3rd Qu.: 84.00   3rd Qu.:170.0  
 Max.   :27           Max.   :53.58   Max.   :117.00   Max.   :272.0  
                      NA's   :32                       NA's   :1      
      dbp               hr              lvef            bnp        afib   
 Min.   : 36.00   Min.   : 31.00   Min.   :0.150   Min.   :1.791   0:218  
 1st Qu.: 71.00   1st Qu.: 67.00   1st Qu.:0.280   1st Qu.:2.523   1: 85  
 Median : 84.00   Median : 84.00   Median :0.380   Median :3.128          
 Mean   : 84.69   Mean   : 88.18   Mean   :0.405   Mean   :3.071          
 3rd Qu.: 97.00   3rd Qu.:105.00   3rd Qu.:0.500   3rd Qu.:3.447          
 Max.   :150.00   Max.   :207.00   Max.   :0.940   Max.   :5.280          
 NA's   :1                                         NA's   :238            
------------------------------------------------------------ 
IPDNa$centre: 28
     centre   gender      bmi             age              sbp       
 Min.   :28   0:45   Min.   :19.67   Min.   : 47.00   Min.   : 85.0  
 1st Qu.:28   1:44   1st Qu.:24.63   1st Qu.: 66.00   1st Qu.:121.0  
 Median :28          Median :28.07   Median : 75.00   Median :132.0  
 Mean   :28          Mean   :28.87   Mean   : 75.73   Mean   :136.5  
 3rd Qu.:28          3rd Qu.:33.07   3rd Qu.: 83.00   3rd Qu.:149.0  
 Max.   :28          Max.   :41.96   Max.   :129.00   Max.   :222.0  
                                                                     
      dbp               hr              lvef             bnp        afib  
 Min.   : 56.00   Min.   : 41.00   Min.   :0.1500   Min.   :1.385   0:45  
 1st Qu.: 72.00   1st Qu.: 73.00   1st Qu.:0.2700   1st Qu.:2.196   1:44  
 Median : 85.00   Median : 87.00   Median :0.3800   Median :2.423         
 Mean   : 84.55   Mean   : 90.34   Mean   :0.4274   Mean   :2.528         
 3rd Qu.: 95.00   3rd Qu.:107.00   3rd Qu.:0.5000   3rd Qu.:2.818         
 Max.   :130.00   Max.   :174.00   Max.   :1.7300   Max.   :3.893         
                                                    NA's   :34            

micemd documentation built on Oct. 15, 2021, 5:10 p.m.