Spellman: CDC15 Yeast Gene Expression Dataset

In minerva: Maximal Information-Based Nonparametric Exploration for Variable Analysis

Description

The Spellman dataset provides the gene expression data measured (on a custom platform) in Saccharomyces cerevisiae cell cultures that have been synchronized at different points of the cell cycle by using a temperature-sensitive mutation (cdc15-2), which arrestes cells late in mitosis at the restrictive temperature (it can cause heat-shock).

Usage

Spellman

Format

23 rows x 4382 columns: 4381 transcripts (columns 2:4382) measured at 23 timepoints (column 1).

Source

The original data were published by Spellman and colleagues in Mol. Biol. Cell (1998) as the Botstein dataset. Here we include the version of the dataset as processed by Reshef and colleagues for the MINE statistics original article published in Science (2011) (details are provided in the supplementary material).

References

D. Reshef, Y. Reshef, H. Finucane, S. Grossman, G. McVean, P. Turnbaugh, E. Lander, M. Mitzenmacher, P. Sabeti. (2011) Detecting novel associations in large datasets. Science 334, 6062 (http://www.exploredata.net).

P. T. Spellman, G. Sherlock, M. Q. Zhang, V. R. Iyer, K. Anders, M. B. Eisen, P. O. Brown, D. Botstein, B. Futcher. (1998) Comprehensive Identification of Cell Cycle–regulated Genes of the Yeast Saccharomyces cerevisiae by Microarray Hybridization. Mol. Biol. Cell, 9:12 3273–3297.

minerva documentation built on June 17, 2021, 9:09 a.m.