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mmrm: Mixed Models for Repeated Measures
Mixed models for repeated measures (MMRM) are a popular choice for analyzing longitudinal continuous outcomes in randomized clinical trials and beyond; see Cnaan, Laird and Slasor (1997) <doi:10.1002/(SICI)1097-0258(19971030)16:20%3C2349::AID-SIM667%3E3.0.CO;2-E> for a tutorial and Mallinckrodt, Lane, Schnell, Peng and Mancuso (2008) <doi:10.1177/009286150804200402> for a review. This package implements MMRM based on the marginal linear model without random effects using Template Model Builder ('TMB') which enables fast and robust model fitting. Users can specify a variety of covariance matrices, weight observations, fit models with restricted or standard maximum likelihood inference, perform hypothesis testing with Satterthwaite or Kenward-Roger adjustment, and extract least square means estimates by using 'emmeans'.
Getting started
Package overview
Between-Within"
Coefficients Covariance Matrix Adjustment"
Comparison with other software"
Covariance Structures"
Details of Hypothesis Testing"
Details of Weighted Least Square Empirical Covariance"
Kenward-Roger"
Mixed Models for Repeated Measures"
Model Fitting Algorithm"
Package Introduction"
Package Structure"
Prediction and Simulation"
Satterthwaite"
Browse package contents
Package details |
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| Author | Daniel Sabanes Bove [aut, cre] (<https://orcid.org/0000-0002-0176-9239>), Liming Li [aut], Julia Dedic [aut], Doug Kelkhoff [aut], Kevin Kunzmann [aut], Brian Matthew Lang [aut], Christian Stock [aut], Ya Wang [aut], Craig Gower-Page [ctb], Dan James [aut], Jonathan Sidi [aut], Daniel Leibovitz [aut], Daniel D. Sjoberg [aut] (<https://orcid.org/0000-0003-0862-2018>), Lukas A. Widmer [ctb] (<https://orcid.org/0000-0003-1471-3493>), Boehringer Ingelheim Ltd. [cph, fnd], Gilead Sciences, Inc. [cph, fnd], F. Hoffmann-La Roche AG [cph, fnd], Merck Sharp & Dohme, Inc. [cph, fnd], AstraZeneca plc [cph, fnd], inferential.biostatistics GmbH [cph, fnd] |
| Maintainer | Daniel Sabanes Bove <daniel.sabanes_bove@rconis.com> |
| License | Apache License 2.0 |
| Version | 0.3.14 |
| URL | https://openpharma.github.io/mmrm/ |
| Package repository | View on CRAN |
| Installation |
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