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knitr::opts_chunk$set( collapse = TRUE, comment = "#>" )
library(monitOS)
# OS monitoring guideline retrospectively applied to Motivating Example 1 # with delta null = 1.3, delta alt = 0.80, gamma_FA = 0.025 and beta_PA = 0.10. bounds( events = c(60, 89, 110, 131, 178), power_int = 0.9, # βPA falsepos = 0.025, # γFA hr_null = 1.3, # δnull hr_alt = 0.8, # δalt rand_ratio = 1, hr_marg_benefit = NULL )
# OS monitoring guideline applied to Motivating Example 2 # with delta null = 4/3, delta alt = 0.7, gamma_FA = 0.20, beta_PA = 0.1, # randomization ratio 2 and 0.95 HR marginal benefit bounds( events = c(60, 89, 110, 131, 178), power_int = 0.9, # βPA falsepos = 0.025, # γFA hr_null = 1.3, # δnull hr_alt = 0.8, # δalt rand_ratio = 2, # rand_ratio hr_marg_benefit = 0.95 ) # Marginal HR benefit
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