compute_delta: Default minimum clinically meaningful shift for different...

In msprog: Reproducible Assessment of Disability Course in Multiple Sclerosis

Default minimum clinically meaningful shift for different scales.

Description

Compute the minimum clinically meaningful score change as a function of the reference value for some widely used scales (EDSS, NHPT, T25FW, or SDMT), according to the most established rule for each of these outcomes.

Usage

compute_delta(baseline, outcome = "edss")

Arguments

baseline	Outcome value at baseline.
outcome	One of: "edss" (Extended Disability Status Scale, default); "nhpt" (Nine-Hole Peg Test); "t25fw" (Timed 25-Foot Walk); "sdmt" (Symbol Digit Modalities Test).

Details

Default thresholds are meant to apply to all versions of each test (e.g., dominant or non-dominant hand for NHPT, best time or mean of two trials, etc.).

Value

Minimum clinically meaningful change from the provided baseline value. Specifically:

• EDSS: 1.5 if baseline=0, 1 if 0<baseline<=5.0, 0.5 if baseline>5.0

• NHPT and T25FW: 20⁠%⁠ of baseline

• SDMT: either 4 points or 20⁠%⁠ of baseline.

Examples

compute_delta(4.5) # default outcome is "edss"
compute_delta(55, outcome="sdmt")

msprog documentation built on Sept. 4, 2026, 5:08 p.m.