getOmegas: Generate ETA variance and covariance table

In nlmixr2autoinit: Automatic Generation of Initial Estimates for Population Pharmacokinetic Modeling

Generate ETA variance and covariance table

Description

This function constructs a combined table containing:

• ETA variances (e.g., eta.cl, eta.vc), which represent inter-individual variability (IIV) in pharmacokinetic parameters;

• Derived covariances (e.g., cov.eta_cl_vc) computed from ETA variances and assumed pairwise correlations.

Usage

getOmegas()

Details

ETA variances are initialized to 0.1 by default. Correlations within defined omega blocks (block 1: eta.vmax, eta.km; block 2: eta.cl, eta.vc, eta.vp, eta.vp2, eta.q, eta.q2) are assumed to be 0.1 and used to compute covariances as:

Cov(i, j) = sqrt(Var_i) * sqrt(Var_j) * Corr(i, j)

The resulting output format aligns with Recommended_initial_estimates.

Value

A data.frame with columns: Parameters, Methods, and Values.

Examples

getOmegas()

nlmixr2autoinit documentation built on Nov. 14, 2025, 1:07 a.m.