ofGEM: A Meta-Analysis Approach with Filtering for Identifying Gene-Level Gene-Environment Interactions with Genetic Association Data

Offers a gene-based meta-analysis test with filtering to detect gene-environment interactions (GxE) with association data, proposed by Wang et al. (2018) <doi:10.1002/gepi.22115>. It first conducts a meta-filtering test to filter out unpromising SNPs by combining all samples in the consortia data. It then runs a test of omnibus-filtering-based GxE meta-analysis (ofGEM) that combines the strengths of the fixed- and random-effects meta-analysis with meta-filtering. It can also analyze data from multiple ethnic groups.

Getting started

Package details

AuthorJiebiao Wang, Qianying Liu and Lin S. Chen
MaintainerJiebiao Wang <[email protected]>
URL https://github.com/randel/ofGEM
Package repositoryView on CRAN
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ofGEM documentation built on July 13, 2018, 5:04 p.m.