MR_2SLS: MR_2SLS

In omixVizR: A Toolkit for Omics Data Visualization

MR_2SLS

Description

Perform Two-Stage Least Squares (2SLS) Mendelian Randomization analysis.

Usage

MR_2SLS(
  infile,
  outcome,
  outcome_name,
  prs_cols_match,
  regexpr_pattern,
  standardise = TRUE,
  digits = 3,
  .progress = TRUE
)

Arguments

infile	The input file containing the data.
outcome	The outcome variable.
outcome_name	The name of the outcome variable.
prs_cols_match	The columns to match for PRS.
regexpr_pattern	The regular expression pattern to use for matching.
standardise	Whether to standardise the prs data, Default: TRUE
digits	The number of decimal places to round to, Default: 3
.progress	Whether to show progress, Default: TRUE

Details

This function performs a Two-Stage Least Squares (2SLS) Mendelian Randomization analysis.

Value

A list containing the results of the 2SLS analysis.

Author(s)

Zhen Lu [e-mail]

Siyang Liu [e-mail]

See Also

fread, as.data.table, setattr, setDT select, reexports map str_extract nearPD cov.shrink

omixVizR documentation built on Nov. 5, 2025, 7:23 p.m.