ordcrm: Likelihood-Based Continual Reassessment Method (CRM) Dose Finding Designs

Provides the setup and calculations needed to run a likelihood-based continual reassessment method (CRM) dose finding trial and performs simulations to assess design performance under various scenarios. 3 dose finding designs are included in this package: ordinal proportional odds model (POM) CRM, ordinal continuation ratio (CR) model CRM, and the binary 2-parameter logistic model CRM. These functions allow customization of design characteristics to vary sample size, cohort sizes, target dose-limiting toxicity (DLT) rates, discrete or continuous dose levels, combining ordinal grades 0 and 1 into one category, and incorporate safety and/or stopping rules. For POM and CR model designs, ordinal toxicity grades are specified by common terminology criteria for adverse events (CTCAE) version 4.0. Function 'pseudodata' creates the necessary starting models for these 3 designs, and function 'nextdose' estimates the next dose to test in a cohort of patients for a target DLT rate. We also provide the function 'crmsimulations' to assess the performance of these 3 dose finding designs under various scenarios.

Author
Emily V. Dressler, PhD Zhengyan Huang
Date of publication
2016-11-04 23:54:11
Maintainer
Emily V. Dressler <EmilyVDressler@gmail.com>
License
GPL (>= 2)
Version
1.0.0

View on CRAN

Man pages

crmsimulations
Simulations to Assess operating characteristics of...
nextdose
Estimates the updated model and next dose to be tested for...
pseudodata
Pseudodata for Likelihood-Based Continual Reassessment Method...

Files in this package

ordcrm
ordcrm/NAMESPACE
ordcrm/NEWS.md
ordcrm/R
ordcrm/R/crmsimulations.R
ordcrm/R/fiterations.R
ordcrm/R/constraints.R
ordcrm/R/pseudodata.R
ordcrm/R/nextdose.R
ordcrm/README.md
ordcrm/MD5
ordcrm/DESCRIPTION
ordcrm/man
ordcrm/man/nextdose.Rd
ordcrm/man/pseudodata.Rd
ordcrm/man/crmsimulations.Rd