ordcrm: Likelihood-Based Continual Reassessment Method (CRM) Dose Finding Designs
Version 1.0.0

Provides the setup and calculations needed to run a likelihood-based continual reassessment method (CRM) dose finding trial and performs simulations to assess design performance under various scenarios. 3 dose finding designs are included in this package: ordinal proportional odds model (POM) CRM, ordinal continuation ratio (CR) model CRM, and the binary 2-parameter logistic model CRM. These functions allow customization of design characteristics to vary sample size, cohort sizes, target dose-limiting toxicity (DLT) rates, discrete or continuous dose levels, combining ordinal grades 0 and 1 into one category, and incorporate safety and/or stopping rules. For POM and CR model designs, ordinal toxicity grades are specified by common terminology criteria for adverse events (CTCAE) version 4.0. Function 'pseudodata' creates the necessary starting models for these 3 designs, and function 'nextdose' estimates the next dose to test in a cohort of patients for a target DLT rate. We also provide the function 'crmsimulations' to assess the performance of these 3 dose finding designs under various scenarios.

AuthorEmily V. Dressler, PhD Zhengyan Huang
Date of publication2016-11-04 23:54:11
MaintainerEmily V. Dressler <EmilyVDressler@gmail.com>
LicenseGPL (>= 2)
Version1.0.0
Package repositoryView on CRAN
InstallationInstall the latest version of this package by entering the following in R:
install.packages("ordcrm")

Getting started

README.md

Popular man pages

crmsimulations: Simulations to Assess operating characteristics of...
nextdose: Estimates the updated model and next dose to be tested for...
pseudodata: Pseudodata for Likelihood-Based Continual Reassessment Method...
See all...

All man pages Function index File listing

Man pages

crmsimulations: Simulations to Assess operating characteristics of...
nextdose: Estimates the updated model and next dose to be tested for...
pseudodata: Pseudodata for Likelihood-Based Continual Reassessment Method...

Functions

constraints Source code
crmsimulations Man page Source code
fiterations Source code
nextdose Man page Source code
pseudodata Man page Source code

Files

NAMESPACE
NEWS.md
R
R/crmsimulations.R
R/fiterations.R
R/constraints.R
R/pseudodata.R
R/nextdose.R
README.md
MD5
DESCRIPTION
man
man/nextdose.Rd
man/pseudodata.Rd
man/crmsimulations.Rd
ordcrm documentation built on May 20, 2017, 2:07 a.m.

Questions? Problems? Suggestions? Tweet to @rdrrHQ or email at ian@mutexlabs.com.

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