Description Usage Arguments Value References Examples
View source: R/stats-predprob.r
Lee and Liu's criterion function for determining the trial decision cutoffs based on the predictive probability.
1 | predprob(y, n, nmax, alpha_e, beta_e, p_s, theta_t)
|
y |
the number of responses among n patients treated by the experimental drug at a certain stage of the trial. |
n |
the number of patients treated by the experimental drug at a certain stage of the trial. |
nmax |
the maximum number of patients treated by the experimental drug. |
alpha_e |
the hyperparameter (shape1) of the Beta prior for the experimental drug. |
beta_e |
the hyperparameter (shape2) of the Beta prior for the experimental drug. |
p_s |
the the response rate for the standard drug. |
theta_t |
the prespecified target probability; tipically, θ_T = [0.85, 0.95]. |
prob |
the predictive probability: PP = ∑_{x=0}^{n_{max}-n} P(x | y) I(\Pr(p_E > p_S | y, x) ≥q θ_T) |
Lee, J. J., Liu, D. D. (2008). A predictive probability design for phase II cancer clinical trials. Clinical Trials 5: 93-106.
Yin, G. (2012). Clinical Trial Design: Bayesian and Frequentist Adaptive Methods. New York: Wiley.
1 2 | # p. 97, PP = 0.5656
predprob(16, 23, 40, 0.6, 0.4, 0.6, 0.9)
|
[1] 0.5655589
Add the following code to your website.
For more information on customizing the embed code, read Embedding Snippets.