Implements Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints and longitudinal efficacy measure from multiple treatment cycles and allows individualized dose modification. The package provides a number of model-based phase I designs, including 1 stage models with or without individualized dose modification, 3-stage models with or without individualized dose modification, etc. Functions are provided to recommend dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters.
This package can be installed directly from R by running the following code:
library(phase1PRMD) ?RunPRMD ?SimPRMD
Detailed manual will relase in the near future
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