Applying the global sensitivity analysis workflow to investigate the parameter uncertainty and sensitivity in physiologically based kinetic (PK) models, especially the physiologically based pharmacokinetic/toxicokinetic model with multivariate outputs. The package also provides some functions to check the convergence and sensitivity of model parameters. The workflow was first mentioned in Hsieh et al., (2018) <doi:10.3389/fphar.2018.00588>, then further refined (Hsieh et al., 2020 <doi:10.1016/j.softx.2020.100609>).
Package details |
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Author | Nan-Hung Hsieh [aut, cre] (<https://orcid.org/0000-0003-0163-2766>), Brad Reisfeld [ctb] (<https://orcid.org/0000-0003-1310-1495>), Weihsueh A. Chiu [ctb] (<https://orcid.org/0000-0002-7575-2368>) |
Maintainer | Nan-Hung Hsieh <d99622005@ntu.edu.tw> |
License | GPL-3 | file LICENSE |
Version | 1.2.3 |
URL | https://github.com/nanhung/pksensi https://nanhung.github.io/pksensi/ |
Package repository | View on CRAN |
Installation |
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