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pksensi: Global Sensitivity Analysis in Physiologically Based Kinetic Modeling
Applying the global sensitivity analysis workflow to investigate the parameter uncertainty and sensitivity in physiologically based kinetic (PK) models, especially the physiologically based pharmacokinetic/toxicokinetic model with multivariate outputs. The package also provides some functions to check the convergence and sensitivity of model parameters. The workflow was first mentioned in Hsieh et al., (2018) <doi:10.3389/fphar.2018.00588>, then further refined (Hsieh et al., 2020 <doi:10.1016/j.softx.2020.100609>).
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Package details |
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| Author | Nan-Hung Hsieh [aut, cre] (<https://orcid.org/0000-0003-0163-2766>), Brad Reisfeld [ctb] (<https://orcid.org/0000-0003-1310-1495>), Weihsueh A. Chiu [ctb] (<https://orcid.org/0000-0002-7575-2368>) |
| Maintainer | Nan-Hung Hsieh <d99622005@ntu.edu.tw> |
| License | GPL-3 | file LICENSE |
| Version | 1.2.3 |
| URL | https://github.com/nanhung/pksensi https://nanhung.github.io/pksensi/ |
| Package repository | View on CRAN |
| Installation |
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