pocrm: Dose Finding in Drug Combination Phase I Trials Using PO-CRM

Provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) of Wages, Conaway and O'Quigley (2011) <doi:10.1177/1740774511408748> for use in Phase I trials of combinations of agents. Provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.

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Package details

AuthorNolan A. Wages
Maintainer"Varhegyi, Nikole E. (nev4g)" <[email protected]>
Package repositoryView on CRAN
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pocrm documentation built on May 1, 2019, 7:55 p.m.