Provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) for use in Phase I trials of combinations of agents. Provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.
|Author||Nolan A. Wages|
|Date of publication||2015-04-10 01:31:10|
|Maintainer||"Varhegyi, Nikole (nev4g)" <email@example.com>|