Provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) of Wages, Conaway and O'Quigley (2011) <doi:10.1177/1740774511408748> for use in Phase I trials of combinations of agents. Provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.
|Author||Nolan A. Wages|
|Maintainer||"Varhegyi, Nikole E. (nev4g)" <[email protected]>|
|Package repository||View on CRAN|
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