estcount.bilevel.subgroups: Estimate the Average Treatment Effect of the log risk ratio...

In precmed: Precision Medicine

Estimate the Average Treatment Effect of the log risk ratio in multiple bi-level subgroups defined by the proportions

Description

If only care about the higher subgroup (above cutoff), only need trt.est.high so set onlyhigh to be TRUE Scores are adjusted to the opposite sign if higher.y == FALSE; scores stay the same if higher.y == TRUE; this is because estcount.bilevel.subgroups() always takes the subgroup of the top highest adjusted scores, and higher adjusted scores should always represent high responders of trt=1

Usage

estcount.bilevel.subgroups(
  y,
  x.cate,
  x.ps,
  time,
  trt,
  score,
  higher.y,
  prop,
  onlyhigh,
  ps.method = "glm",
  minPS = 0.01,
  maxPS = 0.99
)

Arguments

y	Observed outcome; vector of size n (observations)
x.cate	Matrix of p.cate baseline covariates; dimension n by p.cate (covariates in the outcome model)
x.ps	Matrix of p.ps baseline covariates (plus a leading column of 1 for the intercept); dimension n by p.ps + 1 (covariates in the propensity score model plus intercept)
time	Log-transformed person-years of follow-up; vector of size n
trt	Treatment received; vector of size n units with treatment coded as 0/1
score	Estimated log CATE scores for all n observations from one of the four methods (boosting, naive Poisson, two regressions, contrast regression); vector of size n
higher.y	A logical value indicating whether higher (TRUE) or lower (FALSE) values of the outcome are more desirable. Default is TRUE.
prop	Proportions corresponding to percentiles in the estimated log CATE scores that define subgroups to calculate ATE for; vector of floats in '(0, 1]' (if onlyhigh=T) or in '(0, 1)' (if onlyhigh=F): Each element of prop represents the high/low cutoff in each bi-level subgroup and the length of prop is number of bi-level subgroups
onlyhigh	Indicator of returning only the ATEs in the higher-than-cutoff category of the bi-level subgroups; boolean
ps.method	A character value for the method to estimate the propensity score. Allowed values include one of: 'glm' for logistic regression with main effects only (default), or 'lasso' for a logistic regression with main effects and LASSO penalization on two-way interactions (added to the model if interactions are not specified in ps.model). Relevant only when ps.model has more than one variable.
minPS	A numerical value (in '[0, 1]') below which estimated propensity scores should be truncated. Default is 0.01.
maxPS	A numerical value (in '(0, 1]') above which estimated propensity scores should be truncated. Must be strictly greater than minPS. Default is 0.99.

Value

ate.est.high: estimated ATEs in the multiple bi-level subgroups that are in the higher-than-cutoff category; vector of size equal to the length of prop; always returned ate.est.low: estimated ATEs in the multiple bi-level subgroups that are in the lower-than-cutoff category; vector of size equal to the length of prop; returned only when onlyhigh == TRUE

precmed documentation built on Oct. 6, 2024, 1:07 a.m.