Description Usage Arguments Value Author(s) References See Also Examples
This function aims at analysing m multiple continuous endpoints with a global procedure. The clinical aim is to be able to detect a mean difference between the test T and the control C product for at least one endpoint among m. This method is based on a multivariate model taking into account the correlations between the m endpoints and possibly some adjustment variables. The result gives only a global decision.
1 | global.1m.analysis(XC, XT, A, alpha = 0.05, n = NULL)
|
XC |
matrix of the outcome for the control group. |
XT |
matrix of the outcome for the test group. |
A |
matrix of the adjustment variables. |
n |
sample size of a group. The sample size needs to be the same for each group. |
alpha |
value which corresponds to the chosen Type-I error rate bound. |
Pvalue |
the p-value of the global test. |
P. Lafaye de Micheaux, B. Liquet and J. Riou
Lafaye de Micheaux P., Liquet B., Marque S., Riou J. (2014). Power and Sample Size Determination in Clinical Trials With Multiple Primary Continuous Correlated Endpoints, Journal of Biopharmaceutical Statistics, 24, 378–397.
global.1m.ssc
,
indiv.1m.ssc
,
indiv.1m.analysis
,
bonferroni.1m.ssc
1 2 3 4 5 6 7 8 9 10 |
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