Zhang2023: Zhang2023

In rchemo: Dimension Reduction, Regression and Discrimination for Chemometrics

Zhang2023

Description

A selection of reduced non-targeted metabolomics datasets from the article of Zhang et al.(2023)

Usage

data(Zhang2023)

Format

A list with 6 components: GCTOF, HILICNEG, HILICPOS, metadata.

CHSNEG

A matrix whose rows are 68 mice and columns are 163 metabolomic variables obtained by LC-MS.

CHSPOS

A matrix whose rows are 68 mice and columns are 288 metabolomic variables obtained by LC-MS.

GCTOF

A matrix whose rows are 68 mice and columns are 108 metabolomic variables obtained by GC-MS.

HILICNEG

A matrix whose rows are 68 mice and columns are 44 metabolomic variables obtained by LC-MS.

HILICPOS

A matrix whose rows are 68 mice and columns are 133 metabolomic variables obtained by LC-MS.

metadata

A matrix whose rows are 68 mice and columns are the genotype group (Mutant/Wild) and the gender (Male/Female).

Details

The 6 samples from 5 mutant groups (Dhfr, Gnpda1, Plk1, Sra1, Ulk3) and the 40 controls were retained, with the exception of 2 animals wM_035 (wild Male) et mM_102 (mutant Male) that had missing values in non-targeted metabolomics. Three HILIC-NEG (Ser_Asn, Théophylline, Val_Asp) and 2 HILIC-POS variables (Ser-His, Thr-Arg) were then removed due to missing or infinite values.

Source

Zhang, Y.; Barupal, D.K.; Fan, S.; Gao, B.; Zhu, C.; Flenniken, A.M.; McKerlie, C.; Nutter, L.M.J.; Lloyd, K.C.K.; Fiehn, O. Sexual Dimorphism of the Mouse Plasma Metabolome Is Associated with Phenotypes of 30 Gene Knockout Lines. Metabolites 2023, 13, 947. https://doi.org/10.3390/metabo13080947

Examples

data(Zhang2023)

X <- Zhang2023$GCTOF
head(X)

Y <- Zhang2023$metadata
head(Y)

rchemo documentation built on June 30, 2026, 5:10 p.m.