permissible_uncertainty: Tolerance intervals of estimated and target limits

In reflimR: Reference Limit Estimation Using Routine Laboratory Data

Tolerance intervals of estimated and target limits

Description

Returns the permissible uncertainty of reference limits.

Usage

permissible_uncertainty(lower.limit, upper.limit, apply.rounding = TRUE)

Arguments

lower.limit	positive number indicating the lower limit of the reference interval
upper.limit	positive number indicating the upper limit of the reference interval
apply.rounding	Boolean indicating whether the tolerance limits should be rounded

Details

The tolerance limits (also called equivalence limits) indicate the permissible uncertainty of a reference limit from a medical point of view (in contrast to the confidence interval, which reflects the statistical point of view). The calculation is based on a recommendation made by the DGKL [1, 2].

Value

Tolerance intervals for the lower and upper reference limits (ranging from lower.lim.low to lower.lim.upp for the lower reference limit and from upper.lim.low to upper.lim.upp for the upper reference limit)

References

1. Haeckel R et al. Permissible limits for uncertainty of measurement in laboratory medicine. Clin Chem Lab Med 2015;53:1161–71. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1515/cclm-2014-0874")}.

2. Haeckel R et al. Equivalence limits of reference intervals for partitioning of population data. J Lab Med 2016; 40: 199-205. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1515/labmed-2016-0002")}.

Examples

permissible_uncertainty(lower.limit = 10, upper.limit = 50)
permissible_uncertainty(10, 50, FALSE)

reflimR documentation built on May 29, 2024, 12:18 p.m.