Description Details Author(s) References

Provides flexible hazard ratio curves allowing non-linear relationships between continuous predictors and survival. To better understand the effects that each continuous covariate has on the outcome, results are expressed in terms of hazard ratio curves, taking a specific covariate value as reference. Confidence bands for these curves are also derived.

Package: | smoothHR |

Type: | Package |

Version: | 1.0.3 |

Date: | 2021-10-06 |

License: | GPL-3 |

LazyLoad: | yes |

LazyData: | yes |

Artur Araújo and Luís Meira-Machado lmachado@math.uminho.pt

Maintainer: Artur Araújo artur.stat@gmail.com

Cadarso-Suarez, C. and Meira-Machado, L. and Kneib, T. and Gude, F. (2010). Flexible hazard ratio curves for continuous predictors in multi-state models: an application to breast cancer data. *Statistical Modelling*, **10(3)**, 291-314. doi: 10.1177/1471082X0801000303

Eilers, Paul H. and Marx, Brian D. (1996). Flexible smoothing with B-splines and penalties. *Statistical Science*, **11(2)**, 89-121. doi: 10.1214/ss/1038425655

Hosmer, D. W. and Lemeshow, S. and May, S. (2008). *Applied Survival Analysis: Regression Modeling of Time to Event Data: Second Edition*, John Wiley and Sons Inc., New York, NY.

Hurvich, C. M. and Simonoff, J. S. and Tsai, Chih-Ling (1998). Smoothing parameter selection in nonparametric regression using an improved Akaike information criterion, *JRSSB*, **60(2)**, 271–293. doi: 10.1111/1467-9868.00125

Meira-Machado, L. and Cadarso-Suárez, C. and Gude, F. and Araújo, A. (2013). smoothHR: An R Package for Pointwise Nonparametric Estimation of Hazard Ratio Curves of Continuous Predictors, *Computational and Mathematical Methods in Medicine*, **2013**, Article ID 745742, 11 pages. doi: 10.1155/2013/745742

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