Provides functions for the evaluation of surrogate endpoints when both the surrogate and the true endpoint are failure time variables. The approaches implemented are: (1) the two-step approach (Burzykowski et al, 2001) <DOI:10.1111/1467-9876.00244> with a copula model (Clayton, Plackett, Hougaard) at the first step and either a linear regression of log-hazard ratios at the second step (either adjusted or not for measurement error); (2) mixed proportional hazard models estimated via mixed Poisson GLM (Rotolo et al, 2017 <DOI:10.1177/0962280217718582>).
Package details |
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Author | Federico Rotolo [aut] (<https://orcid.org/0000-0003-4837-6501>), Xavier Paoletti [ctb], Marc Buyse [ctb], Tomasz Burzykowski [ctb], Stefan Michiels [ctb] (<https://orcid.org/0000-0002-6963-2968>), Dan Chaltiel [cre] (<https://orcid.org/0000-0003-3488-779X>) |
Maintainer | Dan Chaltiel <dan.chaltiel@gustaveroussy.fr> |
License | GPL-2 |
Version | 1.1.26 |
URL | https://github.com/Oncostat/surrosurv |
Package repository | View on CRAN |
Installation |
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