Provides functions for the evaluation of surrogate endpoints when both the surrogate and the true endpoint are failure time variables. The approaches implemented are: (1) the twostep approach (Burzykowski et al, 2001) <DOI:10.1111/14679876.00244> with a copula model (Clayton, Plackett, Hougaard) at the first step and either a linear regression of loghazard ratios at the second step (either adjusted or not for measurement error); (2) mixed proportional hazard models estimated via mixed Poisson GLM (Rotolo et al, 2017 <DOI:10.1177/0962280217718582>).
Package details 


Author  Federico Rotolo [aut, cre], Xavier Paoletti [ctr], Marc Buyse [ctr], Tomasz Burzykowski [ctr], Stefan Michiels [ctr] 
Maintainer  Federico Rotolo <[email protected]> 
License  GPL2 
Version  1.1.24 
Package repository  View on CRAN 
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