In tRigon: Toolbox for Integrative Pathomics Analysis

Welcome to tRigon

tRigon stands for toolbox for integrative pathomics analysis and provides users with flexible and efficient ways to evaluate and explore (path-) omics datasets. tRigon is built to be compatible with the framework for large-scale histomorphometry (FLASH) environment, but not limited to it.

tRigon offers several key features:

(1) processing, aggregating and merging of pathomics files with clinical / experiment metadata for aggregation of highly-dimensional data frames.

(2) evaluating the generated pathomics data using descriptive statistics, multiple types of plots, statistical tests, k-means clustering, feature importance algorithms and correlation analysis.

(3) options for downloading plots, generated data, statistical outputs, as well as experiment reports for each analysis step for reproducibility.

Workflow

The use of tRigon is simple and intuitive. Information are available in the README file and you can also follow the extensive user guide in the help tab to perform your analysis.

Demo files for tRigon can be downloaded here in the provided data repository.

Code for our framework for large-scale automated histomorphometry (FLASH) to generate pathomics files can also be accessed here

About tRigon

tRigon is publicly available in the CRAN repository, with source code available on GitLab under a GPL-3 license.

The web application can be installed in R / RStudio using a simple command install.packages("tRigon"), and run locally with the command tRigon::run_tRigon(). Alternatively, the web application can be freely accessed for direct online use at https://labooratory.shinyapps.io/tRigon/.