compute_lipoprotein_fatty_acids: Compute fatty acids in each of the lipoprotein classes and...

In ukbnmr: Removal of Unwanted Technical Variation from UK Biobank NMR Metabolomics Biomarker Data

Compute fatty acids in each of the lipoprotein classes and subclasses

Description

Computes fatty acids in each lipoprotein subclass following the formula derived by Belkadi et al. 2026:

\text{Fatty Acids} = \text{Cholesteryl Esters} + 2 \times Phospholipids + 3 \times Triglycerides

Fatty acids in each lipoprotein class are computed as the sum of the fatty acids in the consituent lipoprotein subclasses.

Usage

compute_lipoprotein_fatty_acids(x)

Arguments

x	data.frame containing NMR metabolomics data from UK Biobank. May either be raw field data output by the Table Exporter tool on the UK Biobank Research Analysis Platform or data with column names corresponding to biomarkers listed in nmr_info.

Details

If your UK Biobank project only has access to a subset of biomarkers, then this function will only return the subset of lipoprotein fatty acids that can be computed from the biomarker data provided.

All biomarkers in the input data are also returned alongside the new biomarkers computed by this function

Value

a data.frame with the additional computed biomarkers.

References

Belkadi A. et al. Size-resolved lipoprotein fatty acid content as a novel nuclear magnetic resonance-derived trait specifically associates with genetic variants that control fatty acid metabolism. J. Proteome Res. (2026) doi: 10.1021/acs.jproteome.6c00107

See Also

nmr_info for list of computed lipoprotein fatty acid biomarkers, compute_lipoprotein_fatty_acids_flags() for obtaining an aggregate of the biomarker QC flags from the biomarkers underlying each computed lipoprotein fatty acid, and extract_biomarkers() for details on how raw field data extracted by the Table Exporter tool is processed.

Examples

ukb_data <- ukbnmr::test_data # Toy example dataset for testing package
nmr <- compute_lipoprotein_fatty_acids(ukb_data)

ukbnmr documentation built on July 7, 2026, 5:08 p.m.