theo_sd_fit: Single-dose theophylline PK data fit

In xpose.nlmixr: Graphical Diagnostics for Pharmacometric Models: Extension to 'nlmixr'

Single-dose theophylline PK data fit

Description

Single-dose theophylline PK data fit using the first-order conditional estimation method with interaction (FOCEI) in 'nlmixr', a modified tibble.

Usage

data("theo_sd_fit")

Format

A tibble with 132 observations and 22 variables, and an additional 13 properties.

ID

Individual identifier, a factor

TIME

Time in hours, a numeric vector

DV

Theophylline concentration, a numeric vector

EVID

Event identifier, a numeric vector

PRED

Population predictions, a numeric vector

RES

Residuals, a numeric vector

WRES

Weighted residuals, a numeric vector

IPRED

Individual predictions, a numeric vector

IRES

Individual residuals, a numeric vector

IWRES

Individual weighted residuals, a numeric vector

CPRED

Conditional predictions, a numeric vector

CRES

Conditional residuals, a numeric vector

CWRES

Conditional weighted residuals, a numeric vector

eta.ka

Interindividual variability in ka, a numeric vector

eta.cl

Interindividual variability in CL/F, a numeric vector

eta.v

Interindividual variability in V/F, a numeric vector

ka

Absorption rate in /h, a numeric vector

cl

Apparent clearance in L/h, a numeric vector

v

Apparent volume of distribution in L, a numeric vector

cp

Theophylline concentration, a numeric vector

depot

Amount of theophylline in the depot compartment, a numeric vector

center

Amount of theophylline in the central compartment, a numeric vector

omega

Omega matrix

omegaR

Omega Correlation matrix

shrink

Shrinkage table, includes skewness, kurtosis, and eta p-values

parFixed

Fixed Effect Parameter Table

theta

Fixed Parameter Estimates

eta

Individual Parameter Estimates

seed

Seed (if applicable)

coefficients

Fixed and random coefficients

meta

Model meta information environment

modelName

Model name (from R function)

dataName

Name of R data input

simInfo

RxODE list for simulation

sigma

List of sigma components and their values

Details

This dataset is an nlmixr fit object for demonstrating the use of xpose.nlmixr.

Source

NONMEM/nlme.

Examples

data(theo_sd_fit)
str(theo_sd_fit)

xpose.nlmixr documentation built on June 7, 2022, 1:10 a.m.