pkpd_m3: An 'xp_xtras' example of an M3 model

In xpose.xtras: Extra Functionality for the 'xpose' Package

An xp_xtras example of an M3 model

Description

A representative PK/PD model with M3 fitting applied.

Usage

pkpd_m3

Format

xp_xtras

An xp_xtras object.

Source

\Sexpr[results=rd]{tools:::Rd_expr_doi("doi:10.1002/psp4.13219")}

References

Beal, S.L. Ways to Fit a PK Model with Some Data Below the Quantification Limit. J Pharmacokinet Pharmacodyn 28, 481-504 (2001). \Sexpr[results=rd]{tools:::Rd_expr_doi("doi:10.1023/A:1012299115260")}

Prybylski JP. Indirect modeling of derived outcomes: Are minor prediction discrepancies a cause for concern? CPT Pharmacometrics Syst Pharmacol. 2024; 00: 1-9. \Sexpr[results=rd]{tools:::Rd_expr_doi("doi:10.1002/psp4.13219")}

Examples

# To establish as a complete categorical DV example:
pkpd_m3 <- pkpd_m3 %>%
  # Need to ensure var types are set
  set_var_types(catdv=BLQ,dvprobs=LIKE) %>%
  # Set probs
  set_dv_probs(1, 1~LIKE, .dv_var = BLQ) %>%
  # Optional, but useful to set levels
  set_var_levels(1, BLQ = lvl_bin())

xpose.xtras documentation built on April 22, 2026, 1:09 a.m.