PEACH: Detection of cell separation–induced gene expression through...

Description Usage Arguments Value Author(s)

Description

PEACH adopts a deconvolution method to detect cell separation–induced genes.

Usage

1
peach_main(ref, bulk, iter = 10^4, parC = 10^-4)

Arguments

iter

The number of iterations. Default is 10000.

parC

A parameter of the spike-and-slab distribution. Default is 10^-4.

res.set

A G by N expression matrix of reference, where G is the gene number and N is the total number of reference.

mix.set

A G by M expression matrix of bulk samples, where G is the gene number and M is the total number of bulk samples.

Value

A list of estimated cell proportions (w), the probability of informative genes (p), the fraction of informative genes per cell type (pi), and the cell-specific profiles (mean).

Author(s)

An-Shun Tai anshuntai@nctu.edu.tw


AshTai/PEACH documentation built on Dec. 17, 2021, 9:45 a.m.