inst/markdown/germline_heritability.markdown

In CRI-iAtlas/iatlas-app: What the Package Does (One Line, Title Case)

Explore the percentage of variance of immune phenotype traits explained by common genetic variance across different ancestry groups.

Heritability analyses were performed using genomic-relatedness-based restricted maximum-likelihood (GREML) and provide estimates of the proportion of phenotypic variance explained by the genetic variance, V(Genotype)/Vp. The analyses were conducted separately within each ancestral subgroup, which were derived from ancestry analysis using the genotype data. Each immune trait is assigned to a particular Category and a particular Module, as described in the manuscript.

Select a subset criteria (Subset by) and a group of interest (Show associated results for) to generate a bar plot summarizing the V(Genotype)/Vp for the immune traits in that group that have p-values lower than the selected p-value threshold. For a visualization of a single phenotype across different ancestry clusters, select 'Immune Feature' in Subset by and the trait of interest in the Show associated results for menu.

For the European ancestry cluster, it is also possible to visualize the percentage of variance of immune traits accounted for by interaction between germline genotypes and immune subtypes (G x Immune Subtype).

CRI-iAtlas/iatlas-app documentation built on Feb. 7, 2025, 9:02 p.m.