inst/markdown/methods/sc-pseudobulk-scoring.md

Title: Geneset Scoring of Pseudobulk single-cell RNA-seq data

Description:

Pseudobulk: Pseudobulk was computed from normalized and log-transformed data, using the get_pseudobulk function from the decoupler python library (Badia-i-Mompel et al, 2022), with mode set to "sum".

Pseudobulk Geneset Enrichment Analysis: The results from pseudobulk were used for GeneSet Enrichment Analysis (Subramanian, 2003). Scores were computed using the run_gsea function from the decoupler python library (Badia-i-Mompel et al, 2022).

Contributors: Carolina Heimann, Clarisse Lau, David Gibbs, Vésteinn Thorsson



CRI-iAtlas/iatlas-app documentation built on Feb. 7, 2025, 9:02 p.m.