README.md

In CompARE-Composite/CompARE-package: Statistical Functions for the Design of Studies with Composite Endpoints

CompARE

CompARE (https://www.grbio.eu/compare/) is a initiative inspired to provide help on issues relating to trials with composite endpoints. CompARE may be used as a tool for calculating the elements needed in the planning phase of clinical trials involving composite endpoints. CompARE comprises two diferent tools:

• A couple of shiny apps for time-to-event and binary endpoints, respectively. You can found more info here
• The R package CompAREdesign

CompAREdesign R package

Functions

The CompAREdesign package contains the following functions:

• surv_tte to compute the survival function for the composite time-to-event endpoint and both components
• effectsize_tte to compute the treatment effect for the composite time-to-event endpoint
• samplesize_tte to compute the sample size for the composite time-to-event endpoint
• ARE_tte to compute the ARE method for time-to-event endpoints
• plot_tte to get four plots related to previous features
• simula_tte to simulate time-to-event data for the time-to-event composite endpoint and its components
• prob_cbe to compute the probability of a composite binary endpoint
• lower_corr to compute the lower bound of Pearson’s correlation
• upper_corr to compute the upper bound for Pearson’s correlation
• effectsize_cbe to compute the treatment effect on the composite binary endpoint
• samplesize_cbe to compute the sample size for composite binary endpoint
• ARE_cbe to compute the ARE method for composite binary endpoint
• simula_cbe to simulate time-to-event data for the binary composite endpoint and its components

Installation

install.packages("CompAREdesign")
library("CompAREdesign")

CompARE-Composite/CompARE-package documentation built on March 4, 2025, 8:18 p.m.