README.md

In DMC21cent/DMC21cent: DMC reports in the 21st century

DMC21cent: An R Package for Enhancing Data Monitoring Committee Decision-Making

{DMC21cent} is an R package designed to provide potential solutions for Data Monitoring Committee (DMC) decision-making processes. This package is developed to support the research paper titled "DMC Reports in the 21st Century: Towards Better Tools for Decision-Making," which can be accessed here.

The following is the abstract of the paper:

Data Monitoring Committees (DMCs) have the important task to protect the safety of current and future patients during the conduct of a clinical study. Unfortunately, their work is often made difficult by voluminous DMC reports that are poorly structured and difficult to digest. In this article, we suggest improved solutions. Starting from a principled approach and building upon previous proposals, we offer concrete and easily understood displays, including related computer code. While leveraging modern tools, the most important is that these displays support the DMC's workflow in answering the relevant questions of interest. We hope that the adoption of these proposals can ease the task of DMCs, and importantly, lead to better decision-making for the benefit of patients.

DMC21cent/DMC21cent documentation built on May 14, 2023, 5:53 p.m.