The Firth package provides an user friendly way to run Firth's penalized-likelihood logistic regression on genomic data.
burdenFirth
: runs the burden Firth test
codeToMinor
: ensures the genotype matrix is coded to the minor allele
imputeToMean
: imputes missing genotype values to the mean dosage
singsnpFirth
: runs the single snp Firth test
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