nTopDeltaCV: nTopDeltaCV

Description Arguments Author(s)

View source: R/featureSelectionFuns.R

Description

Selected informative genes by fitting a support-vector regression to the coefficient of variation (CV) as a function of the mean, and selecting genes having the greatest offset from the fitted curve; this would correspond to genes with higher-than-expected variance. Adpoted from Linnarsson lab python implementation: https://github.com/linnarsson-lab/cytograph/blob/master/cytograph/feature_selection.py. Note this displays a rendency to prioritize lowly expressed genes.

Arguments

cpm

matrix; Matrix containing cpm values.

n

Number of genes to select.

Author(s)

Jason T. Serviss


EngeLab/RNAseqFunctions documentation built on May 5, 2019, 9:43 p.m.