E_state: Moleculors Electrotopological state index
In FedericoViv/Moleculors:

This function requires access to the vertex adjacency matrices, full and suppressed, to the raw inputs, full and suppressed, to the vertex laplacian matrix and to the vertex distance matrix in order to compute the E-state index for the whole molecule. This is computed by calculating first the intrinsic factor for each atom as 2/principal quanto number ^2 x valence degree + 1 / degree of the atom and correcting this factor by a Di equal to the summatory of intrinsic state of atom i - intrinsic state of atom j over the topological distanze r + 1^2. The obtained E-state index I + Di can be used for the single atoms of can be summed to get the E-state of substituent or, as was done in this function, to compute the whole molecule E-state