README.md

In Health-Economics-in-R/QALY: Calculate Quality Adjusted Life Years (QALYs) Gains with Discounting and Inflated Costs

QALY

A QALY is a QALY is a QALY

An R package for quality-adjusted life-years (QALY) calculation and manipulation.

Currently contains functions to:

• Create QALY type object
• Discounting
• Health State Utility Values (HSUV)
• Inflation-adjusted costs

To do

Request welcome; please use Issues

• Other HSUV methods
• Improved plotting

:warning: This package is in development so is not assured to work.

Installing QALY

To install the development version from github:

library(devtools)
install_github("Health-Economics-in-R/QALY")

Then, to load the package, use:

library(QALY)

Motivation

In cost-utility analyses arguably the most commonly used unit of health outcome is the QALY. There are others, most notably the diability-adjusted life-year (DALY). Calculation of QALYs consist of time and utility components. Time may be some predefined time horizon or an individual’s excess life time. The utilities are health preference measures scaled between 0 and 1. These can be derived from such things as patient recorded outcome measures (PROMs), using surveys such as EuroQol-5D (EQ-5D) or the Short Form-36D/Short Form-6D (SF-6D). Co-morbidities, requiring some combining of utilities, may also be required.

QALY calculation in cost-effectiveness analyses is often done in an ad-hoc, project-by-project way. The aim of this package is to standardise these calculations and provide an easy-to-use suite of functions for the most common operations involving QALYs.

Basic example

suppressMessages(library(QALY))

#> Warning: package 'dplyr' was built under R version 3.4.4

#> Warning: package 'purrr' was built under R version 3.4.4

Combined two co-morbidity utilities using the product approach:

HSUV_prod <- HSUV(method = "prod") 
tot_utility <- HSUV_prod(c(0.9, 0.8))

TODO use expected remaining life time…

Create a adjusted life-year type object which contains all the information needed to do subsequent operations:

personHealthYears <-
  person_health_years(
    start_year = 2016,
    end_year = 2020,
    age = 33,
    time_horizon = NA,
    utility = tot_utility,
    discount_rate = 0.035)

Calculate QALYS:

HRQoL_year <- total_QALYs(personHealthYears)

print(HRQoL_year)

#>   [1] 0.5900000 0.5700483 0.5507713 0.5321462        NA        NA        NA
#>   [8]        NA        NA        NA        NA        NA        NA        NA
#>  [15]        NA        NA        NA        NA        NA        NA        NA
#>  [22]        NA        NA        NA        NA        NA        NA        NA
#>  [29]        NA        NA        NA        NA        NA        NA        NA
#>  [36]        NA        NA        NA        NA        NA        NA        NA
#>  [43]        NA        NA        NA        NA        NA        NA        NA
#>  [50]        NA        NA        NA        NA        NA        NA        NA
#>  [57]        NA        NA        NA        NA        NA        NA        NA
#>  [64]        NA        NA        NA        NA        NA        NA        NA
#>  [71]        NA        NA        NA        NA        NA        NA        NA
#>  [78]        NA        NA        NA        NA        NA        NA        NA
#>  [85]        NA        NA        NA        NA        NA        NA        NA
#>  [92]        NA        NA        NA        NA        NA        NA        NA
#>  [99]        NA        NA
#> attr(,"class")
#> [1] "HRQoL"   "numeric"
#> attr(,"person_health_years")
#> $start_year
#> [1] 2016
#> 
#> $end_year
#> [1] 2020
#> 
#> $delay
#> [1] 0
#> 
#> $age
#> [1] 33
#> 
#> $time_horizon
#> [1] 4
#> 
#> $utility
#> [1] 0.72 0.72 0.72 0.72
#> 
#> $QoL
#> [1] 0.87 0.87 0.87 0.87 0.87
#> 
#> $discount_rate
#> [1] 0.035
#> 
#> $death
#> [1] NA
#> 
#> $utility_method
#> [1] "add"
#> 
#> $period
#> [1] 1 1 1 1
#> 
#> attr(,"class")
#> [1] "person_health_years" "list"

summary(HRQoL_year)

#>    Min. 1st Qu.  Median    Mean 3rd Qu.    Max.    NA's 
#>  0.5322  0.5461  0.5604  0.5607  0.5750  0.5900      96

Print a graph of the HRQoL over time: using ggplot2?

plot(HRQoL_year)

See package vignette for more details and examples.

License

GPL-3 ©

Health-Economics-in-R/QALY documentation built on Oct. 26, 2020, 2:28 a.m.