params_costs_tx: Treatment cost parameters

In InnovationValueInitiative/IVI-NSCLC: The IVI-NSCLC model

Description

Information on dosage, strength, pricing, and administration costs needed to estimate costs of treatments sequences.

Usage

params_costs_tx

Format

A list with the following elements:

dosage

A data.table containing information on dosage for each agent used for treatments that can be included in a treatment sequence. The variables strength1, strength2, quantity1, quantity2, units_per_day, and duration_days can be modified to change annualized costs.

agent_name

Name of the agent used in the treatment; combination therapies will have more than one agents.

dosage

Amount, number. and frequency of doses over a specified time period.

dose

Specified amount of medication taken at one time. By default, doses based on body surface area (BSA) and weight are based on mean BSA and weight, respectively.

unit

The unit used to compute costs.

strength1

The amount of the drug in a single dosage form (e.g., tablet or vial).

strength2

If a unit consists of multiple dosage forms, then the amount of the drug in the dosage form not included in strength1.

quantity1

Quantity of dosage form specified in strength1 in a unit.

quantity2

Quantity of dosage form specified in strength2 in a unit.

units_per_day

Number of units of the treatment (based on dosage) used per day.

duration_days

Number of days to use the treatment. If used until progression, then must equal Inf.

source

Source for dosage information.

acquisition_costs

A data.table of acquisition costs by agent and strength. Default costs are based on wholesale acquisition costs (WACs). The variable acquisition_cost can be modified to change annualized acquisition costs.

agent_name

Name of the agent

strength

The amount of the agent in a given unit of the dosage form.

acquisition_cost

The acquisition cost of an agent for a given strength.

source

Source used for acquisition cost.

discounts

agent_name

Name of the agent.

discount_lower

Lower bound for discount and rebates as a proportion of acquisition_cost in the acquisition_costs table. Assumed to follow a uniform distribution in the probabilistic sensitivity analysis.

discount_upper

Upper bound for discount and rebates as a proportion of acquisition_cost in the acquisition_costs table. Assumed to follow a uniform distribution in the probabilistic sensitivity analysis.

administration_costs

A data.table of administration costs. The variable costs can be modified to change annualized administration costs.

agent_name

Name of the agent.

administration_cost

The costs of administering an agent.

source

Source used for administration cost.

lookup

A lookup data.table used to match treatments from the treatments table to agents comprising a particular treatment.

tx_name

Name of treatment.

agent_name1

Name of first agent used for treatment.

agent_name2

Name of second agent used for treatment.

agent_name3

Name of third agent used for treatment.

agent_name4

Name of fourth agent used for treatment.

Examples

print(params_costs_tx)

InnovationValueInitiative/IVI-NSCLC documentation built on July 25, 2019, 8:03 p.m.