calculate_mgfr_ss: Iohexol Single Sample (SS) measure of GFR

In JMLuther/tabletools: Helpful Tools to Make html Tables

Iohexol Single Sample (SS) measure of GFR

Description

This method uses a single sample measurement of iohexol to determine GFR (glomerular filtration rate), by optimizing 3 equations initially described by Jacobsson. Relevant Methods and recommendations are detailed in the European Kidney Function Consortium statment paper. The R script is modified from the supplemental methods supplied in that paper, which also supplies an excel spreadsheet which can be used for comparison. One minor difference is the use of a newer and more accurate formula to estimate ECV.

Usage

calculate_mgfr_ss(
  egfr,
  height,
  weight,
  sex,
  age,
  iohexol_m,
  iohexol_ss,
  time_ss,
  weight_units = "kg",
  height_units = "m",
  ecv_method = "Faucon"
)

Arguments

egfr	Model-based estimate of GFR (eg CKD-EPI eGFR). Used as a starting point for estimation.
height	Height, cm
weight	Weight, kg
sex	Sex (M/F)
age	Age, years
iohexol_m	Iohexol dose injected (mcg)
iohexol_ss	Iohexol concentration (mcg/mL)
time_ss	Time of iohexol sample (minutes)
weight_units	Weight units, if not in kg
height_units	Height units, if not in cm
ecv_method	ECV Formula (default = "Faucon"; also can use "Granerus")

Value

data.frame with 'mgfr_ss' (non-indexed) and 'mgfr_ss_bsa' (GFR indexed to standard BSA of 1.73m2)

See Also

[calculate_ecv()] for ECV calculation [calculate_bsa()] for BSA calculation

Examples

calculate_mgfr_ss(egfr=40, 
                  height = 168, weight = 87, 
                  sex="mALE", age=80, 
                  iohexol_m = 3273820,
                  iohexol_ss= 60,
                  time_ss=390)
                  
# used alternate ECV calculation (doesn't make much difference)
calculate_mgfr_ss(egfr=40, 
                  height = 168, weight = 87, 
                  sex="male", age=80, ecv_method = "Granerus",
                  iohexol_m = 3273820,
                  iohexol_ss= 60,
                  time_ss=390)

JMLuther/tabletools documentation built on April 14, 2025, 3:09 a.m.