adjust_sodium_for_glucose: Adjust sodium for hyperglycaemia

In LS31/clinicalcalculations: Clinical calculations

Description

Hyperglycaemia can lead to hypertonic hyponatriemia. Using observational data, the following formula predicts sodium levels after correction of glucose: \text{Na}_{predicted} = \text{Na}_\text{measured} + κ \times \frac{\text{glucose} - 5.6}{5.6}, where κ is 1.6 when derived from the publication by Katz and 2.4 when derived from more recent work by Hillier (default).

Usage

adjust_sodium_for_glucose(sodium, glucose, method = "Hillier")

Arguments

sodium	Measured sodium level (mmol/l).
glucose	Measured glucose level (mmol/l).
method	Formula. Options are: "Hillier" (default), "Katz".

Value

Glucose-adjusted sodium level (mmol/l), or NA if any parameters are NA.

Caveats

It's just a prediction, and the choice between both formulae may result in quite different predictions.

References

Katz, M. A. Hyperglycemia-Induced Hyponatremia — Calculation of Expected Serum Sodium Depression. N Engl J Med 289, 843–844 (1973). and Hillier, T. A., Abbott, R. D. & Barrett, E. J. Hyponatremia: evaluating the correction factor for hyperglycemia. The American Journal of Medicine 106, 399–403 (1999)..

See Also

units::set_units(), units::drop_units()

LS31/clinicalcalculations documentation built on Nov. 20, 2020, 6:59 a.m.