PD1highCD8Tscore-package: PD1highCD8Tscore

In Liulab/PD1highCD8Tscore: Quantify PD-1hiCD8+ T cells in tumor environment

Description

A transcriptional signature to quantify the fraction of PD-1hiCD8+ T cells in tumor environment.

Details

Patients with high signature scores are more likely to response to immune checkpoint inhibitors, and are associated with increased clinical outcome. getSigScore, calculate PD-1hi CD8+ T cell signature score getIPS, Immunophenoscore (IPS) was calculated by a script supplied by The Cancer Immunome Atlas ICIResponse, explore the association between a marker and ICI therapy in datasets. Six datasets about expression matrix and clinical information associated with response to immune checkpoint inhibitors

Author(s)

Zhenyu Yang Maintainer: Yulan Deng

References

Tumor-infiltrating PD-1hiCD8+ T cell as potential biomarker for immune checkpoint inhibitors in multiple cancers: an integrative study.

Liulab/PD1highCD8Tscore documentation built on March 15, 2021, 1:14 a.m.