getPower: Power estimation for IndOR

In MathieuEmily/IndOR: Testing for SNPxSNP Interaction with the IndOR method

Description

getPower computes the theoretical power for IndOR to detect a predifined disease model.

Usage

getPower(pDisease,pDiseaseBase,type,pA,pB,nInd,r,ratioCC)

Arguments

pDisease	numeric. pDisease is unconditional probability of the disease.
pDiseaseBase	numeric. pDisease is probability of the disease conditional to the baseline odds.
type	numeric. type is the disease model.
pA	numeric. pA is the MAF for the first SNP.
pB	numeric. pB is the MAF for the second SNP.
nInd	numeric. nInd is the number of individuals.
r	numeric. r is the correlation measure of Linkage Disequilibrium between the two SNPs.
ratioCC	numeric. ratioCC is Case-to-controls ratio.

Value

A list with class "GGItest" containing the following components:

alpha	The baseline odds of the disease model
theta	The strength of the disease model
power	The power of IndOR to detect the disease model

References

Mathieu Emily (2012) IndOR: A new statistical procedure to test for SNP-SNP epistasis in Genome-Wide Association Studies, Statistics In Medicine, 31(21) :2359-2373

See Also

IndOR

MathieuEmily/IndOR documentation built on May 7, 2019, 4:33 p.m.