tests/testthat/_snaps/independent-testing-tlf_ae_specific_subgroup.md
In Merck/metalite.ae: Adverse Events Analysis Using 'metalite'
rtf output: n, and prop w/o total
Code
tbl
Output
$components
[1] "soc" "par"
$group
[1] "Placebo" "Low Dose" "High Dose"
$subgroup
[1] "f" "m"
$display_subgroup_total
[1] TRUE
$meta
ADaM metadata:
.$data_population Population data with 254 subjects
.$data_observation Observation data with 1191 records
.$plan Analysis plan with 18 plans
Analysis population type:
name id group var subset label
1 'apat' 'USUBJID' 'TRTA' SAFFL == 'Y' 'All Participants as Treated'
Analysis observation type:
name id group var subset label
1 'wk12' 'USUBJID' 'TRTA' SAFFL == 'Y' 'Weeks 0 to 12'
2 'wk24' 'USUBJID' 'TRTA' AOCC01FL == 'Y' 'Weeks 0 to 24'
Analysis parameter type:
name label
1 'rel' 'drug-related adverse events'
2 'aeosi' 'adverse events of special interest'
3 'any' 'any adverse events'
4 'ser' 'serious adverse events'
subset
1 AEREL %in% c('POSSIBLE', 'PROBABLE')
2 AEOSI == 'Y'
3
4 AESER == 'Y'
Analysis function:
name label
1 'ae_summary' 'Table: adverse event summary'
2 'ae_listing' 'Listing: adverse event'
3 'ae_exp_adj' 'Exposure Adjusted Incident Rate'
4 'ae_specific' 'Table: specific adverse event'
$population
[1] "apat"
$observation
[1] "wk12"
$parameter
[1] "rel"
$out_all
$out_all$F
List of 15
$ meta :List of 7
$ population : chr "apat"
$ observation : chr "wk12"
$ parameter : chr "rel"
$ n :'data.frame': 138 obs. of 4 variables:
$ order : num [1:138] 1 100 200 900 1000 ...
$ group : chr [1:4] "Placebo" "Low Dose" "High Dose" "Total"
$ reference_group: num 1
$ prop :'data.frame': 138 obs. of 4 variables:
$ diff :'data.frame': 138 obs. of 2 variables:
$ n_pop :'data.frame': 1 obs. of 4 variables:
$ name : chr [1:138] "Participants in population" "with one or more drug-related adverse events" "with no drug-related adverse events" "" ...
$ soc_name : chr [1:138] NA NA NA NA ...
$ components : chr [1:2] "soc" "par"
$ prepare_call : language FUN(meta = X[[i]], population = ..1, observation = ..2, parameter = ..3, components = ..4)
$out_all$M
List of 15
$ meta :List of 7
$ population : chr "apat"
$ observation : chr "wk12"
$ parameter : chr "rel"
$ n :'data.frame': 138 obs. of 4 variables:
$ order : num [1:138] 1 100 200 900 1000 ...
$ group : chr [1:4] "Placebo" "Low Dose" "High Dose" "Total"
$ reference_group: num 1
$ prop :'data.frame': 138 obs. of 4 variables:
$ diff :'data.frame': 138 obs. of 2 variables:
$ n_pop :'data.frame': 1 obs. of 4 variables:
$ name : chr [1:138] "Participants in population" "with one or more drug-related adverse events" "with no drug-related adverse events" "" ...
$ soc_name : chr [1:138] NA NA NA NA ...
$ components : chr [1:2] "soc" "par"
$ prepare_call : language FUN(meta = X[[i]], population = ..1, observation = ..2, parameter = ..3, components = ..4)
$out_all$Total
List of 15
$ meta :List of 7
$ population : chr "apat"
$ observation : chr "wk12"
$ parameter : chr "rel"
$ n :'data.frame': 138 obs. of 4 variables:
$ order : num [1:138] 1 100 200 900 1000 ...
$ group : chr [1:4] "Placebo" "Low Dose" "High Dose" "Total"
$ reference_group: num 1
$ prop :'data.frame': 138 obs. of 4 variables:
$ diff :'data.frame': 138 obs. of 2 variables:
$ n_pop :'data.frame': 1 obs. of 4 variables:
$ name : chr [1:138] "Participants in population" "with one or more drug-related adverse events" "with no drug-related adverse events" "" ...
$ soc_name : chr [1:138] NA NA NA NA ...
$ components : chr [1:2] "soc" "par"
$ prepare_call : language prepare_ae_specific(meta = meta, population = population, observation = observation, parameter = parameter, | __truncated__
$tbl
name Fn_1 Fprop_1 Fn_2
96 Participants in population 53 <NA> 50
138 with one or more drug-related adverse events 28 (52.8) 41
137 with no drug-related adverse events 25 (47.2) 9
1 NA <NA> NA
33 Cardiac disorders 4 (7.5) 4
22 Atrial fibrillation 1 (1.9) 0
23 Atrial flutter 0 (0.0) 0
24 Atrioventricular block first degree 1 (1.9) 0
25 Atrioventricular block second degree 0 (0.0) 0
30 Bradycardia 1 (1.9) 0
31 Bundle branch block right 0 (0.0) 0
34 Cardiac failure congestive 1 (1.9) 0
86 Myocardial infarction 2 (3.8) 1
93 Palpitations 0 (0.0) 0
112 Sinus arrhythmia 0 (0.0) 0
113 Sinus bradycardia 2 (3.8) 1
122 Supraventricular extrasystoles 0 (0.0) 1
129 Ventricular extrasystoles 0 (0.0) 1
134 Wolff-parkinson-white syndrome 0 (0.0) 1
40 Congenital, familial and genetic disorders 0 (0.0) 0
130 Ventricular septal defect 0 (0.0) 0
50 Ear and labyrinth disorders 0 (0.0) 2
125 Tinnitus 0 (0.0) 1
131 Vertigo 0 (0.0) 1
57 Eye disorders 0 (0.0) 0
132 Vision blurred 0 (0.0) 0
62 Gastrointestinal disorders 1 (1.9) 6
2 Abdominal pain 0 (0.0) 1
46 Diarrhoea 0 (0.0) 3
48 Dyspepsia 1 (1.9) 0
63 Gastrooesophageal reflux disease 1 (1.9) 0
87 Nausea 0 (0.0) 2
110 Salivary hypersecretion 0 (0.0) 0
120 Stomach discomfort 0 (0.0) 0
133 Vomiting 0 (0.0) 2
64 General disorders and administration site conditions 11 (20.8) 23
5 Application site bleeding 0 (0.0) 1
6 Application site dermatitis 2 (3.8) 5
7 Application site desquamation 0 (0.0) 0
8 Application site discharge 0 (0.0) 0
9 Application site discolouration 0 (0.0) 0
10 Application site erythema 2 (3.8) 5
11 Application site induration 0 (0.0) 0
12 Application site irritation 3 (5.7) 6
13 Application site pain 0 (0.0) 0
14 Application site perspiration 0 (0.0) 0
15 Application site pruritus 4 (7.5) 12
16 Application site reaction 0 (0.0) 0
17 Application site swelling 0 (0.0) 0
18 Application site urticaria 0 (0.0) 0
19 Application site vesicles 0 (0.0) 1
20 Application site warmth 0 (0.0) 1
21 Asthenia 1 (1.9) 0
35 Chest discomfort 0 (0.0) 0
36 Chills 0 (0.0) 0
59 Fatigue 1 (1.9) 1
60 Feeling abnormal 0 (0.0) 0
81 Malaise 0 (0.0) 0
89 Oedema 0 (0.0) 1
90 Oedema peripheral 0 (0.0) 0
92 Pain 0 (0.0) 1
74 Injury, poisoning and procedural complications 0 (0.0) 2
56 Excoriation 0 (0.0) 0
58 Fall 0 (0.0) 1
117 Skin laceration 0 (0.0) 1
135 Wound 0 (0.0) 1
76 Investigations 2 (3.8) 2
28 Blood creatine phosphokinase increased 0 (0.0) 0
29 Body temperature increased 0 (0.0) 1
51 Electrocardiogram st segment depression 1 (1.9) 1
52 Electrocardiogram t wave inversion 0 (0.0) 0
67 Heart rate increased 0 (0.0) 0
68 Heart rate irregular 1 (1.9) 0
82 Metabolism and nutrition disorders 3 (5.7) 0
42 Decreased appetite 1 (1.9) 0
61 Food craving 1 (1.9) 0
73 Increased appetite 1 (1.9) 0
84 Musculoskeletal and connective tissue disorders 0 (0.0) 0
85 Myalgia 0 (0.0) 0
111 Shoulder pain 0 (0.0) 0
88 Nervous system disorders 3 (5.7) 8
26 Balance disorder 0 (0.0) 1
32 Burning sensation 0 (0.0) 0
38 Complex partial seizures 0 (0.0) 1
41 Coordination abnormal 0 (0.0) 1
47 Dizziness 1 (1.9) 3
66 Headache 2 (3.8) 0
70 Hypersomnia 0 (0.0) 0
78 Lethargy 0 (0.0) 0
94 Paraesthesia oral 0 (0.0) 1
95 Parosmia 0 (0.0) 0
119 Somnolence 0 (0.0) 0
121 Stupor 0 (0.0) 0
123 Syncope 0 (0.0) 4
124 Syncope vasovagal 0 (0.0) 0
126 Transient ischaemic attack 0 (0.0) 0
100 Psychiatric disorders 1 (1.9) 6
3 Agitation 0 (0.0) 2
4 Anxiety 0 (0.0) 3
39 Confusional state 0 (0.0) 1
43 Delirium 0 (0.0) 0
44 Depressed mood 0 (0.0) 0
65 Hallucination, visual 0 (0.0) 0
75 Insomnia 0 (0.0) 0
77 Irritability 1 (1.9) 1
79 Libido decreased 0 (0.0) 0
80 Listless 0 (0.0) 0
109 Restlessness 0 (0.0) 0
106 Renal and urinary disorders 0 (0.0) 1
54 Enuresis 0 (0.0) 1
83 Micturition urgency 0 (0.0) 0
107 Reproductive system and breast disorders 1 (1.9) 0
97 Pelvic pain 1 (1.9) 0
108 Respiratory, thoracic and mediastinal disorders 2 (3.8) 0
49 Dyspnoea 1 (1.9) 0
53 Emphysema 1 (1.9) 0
114 Skin and subcutaneous tissue disorders 12 (22.6) 21
27 Blister 0 (0.0) 2
37 Cold sweat 0 (0.0) 0
45 Dermatitis contact 0 (0.0) 0
55 Erythema 6 (11.3) 7
69 Hyperhidrosis 1 (1.9) 1
98 Pruritus 6 (11.3) 12
99 Pruritus generalised 0 (0.0) 0
101 Rash 2 (3.8) 6
102 Rash erythematous 0 (0.0) 1
103 Rash maculo-papular 0 (0.0) 0
104 Rash papular 0 (0.0) 0
105 Rash pruritic 0 (0.0) 1
115 Skin exfoliation 0 (0.0) 1
116 Skin irritation 2 (3.8) 5
118 Skin ulcer 0 (0.0) 0
127 Urticaria 0 (0.0) 0
128 Vascular disorders 0 (0.0) 2
71 Hypertension 0 (0.0) 1
72 Hypotension 0 (0.0) 1
91 Orthostatic hypotension 0 (0.0) 0
136 Wound haemorrhage 0 (0.0) 0
Fprop_2 Fn_3 Fprop_3 Mn_1 Mprop_1 Mn_2 Mprop_2 Mn_3 Mprop_3 Totaln_1
96 <NA> 40 <NA> 33 <NA> 34 <NA> 44 <NA> 86
138 (82.0) 32 (80.0) 16 (48.5) 32 (94.1) 38 (86.4) 44
137 (18.0) 8 (20.0) 17 (51.5) 2 (5.9) 6 (13.6) 42
1 <NA> NA <NA> NA <NA> NA <NA> NA <NA> NA
33 (8.0) 4 (10.0) 2 (6.1) 3 (8.8) 0 (0.0) 6
22 (0.0) 2 (5.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
23 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
24 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
25 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
30 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
31 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
34 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
86 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 2
93 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
112 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
113 (2.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 2
122 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
129 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
134 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
40 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
130 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
50 (4.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
125 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
131 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
57 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 0
132 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 0
62 (12.0) 3 (7.5) 3 (9.1) 2 (5.9) 7 (15.9) 4
2 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
46 (6.0) 0 (0.0) 3 (9.1) 0 (0.0) 2 (4.5) 3
48 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 1
63 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
87 (4.0) 2 (5.0) 0 (0.0) 1 (2.9) 1 (2.3) 0
110 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 3 (6.8) 0
120 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
133 (4.0) 0 (0.0) 0 (0.0) 0 (0.0) 3 (6.8) 0
64 (46.0) 17 (42.5) 7 (21.2) 20 (58.8) 18 (40.9) 18
5 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
6 (10.0) 4 (10.0) 3 (9.1) 4 (11.8) 3 (6.8) 5
7 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
8 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
9 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
10 (10.0) 5 (12.5) 1 (3.0) 7 (20.6) 10 (22.7) 3
11 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
12 (12.0) 5 (12.5) 0 (0.0) 3 (8.8) 4 (9.1) 3
13 (0.0) 2 (5.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
14 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (4.5) 0
15 (24.0) 10 (25.0) 2 (6.1) 10 (29.4) 12 (27.3) 6
16 (0.0) 1 (2.5) 1 (3.0) 0 (0.0) 0 (0.0) 1
17 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 1 (2.3) 0
18 (0.0) 1 (2.5) 0 (0.0) 2 (5.9) 0 (0.0) 0
19 (2.0) 3 (7.5) 1 (3.0) 3 (8.8) 3 (6.8) 1
20 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
21 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
35 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
36 (0.0) 0 (0.0) 1 (3.0) 1 (2.9) 0 (0.0) 1
59 (2.0) 4 (10.0) 0 (0.0) 1 (2.9) 0 (0.0) 1
60 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
81 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 1 (2.3) 0
89 (2.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
90 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
92 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
74 (4.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
56 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
58 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
117 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
135 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
76 (4.0) 1 (2.5) 2 (6.1) 0 (0.0) 0 (0.0) 4
28 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
29 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
51 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
52 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
67 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
68 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
82 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 3
42 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 1
61 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
73 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
84 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 1 (2.3) 1
85 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
111 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
88 (16.0) 7 (17.5) 2 (6.1) 4 (11.8) 8 (18.2) 5
26 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
32 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (4.5) 0
38 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
41 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
47 (6.0) 2 (5.0) 1 (3.0) 3 (8.8) 4 (9.1) 2
66 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 2
70 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
78 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 0
94 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
95 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
119 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
121 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
123 (8.0) 2 (5.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
124 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
126 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
100 (12.0) 1 (2.5) 1 (3.0) 3 (8.8) 4 (9.1) 2
3 (4.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
4 (6.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
39 (2.0) 0 (0.0) 1 (3.0) 1 (2.9) 0 (0.0) 1
43 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
44 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
65 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
75 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (4.5) 0
77 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
79 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
80 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
109 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
106 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
54 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
83 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
107 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
97 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
108 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2
49 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
53 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
114 (42.0) 13 (32.5) 5 (15.2) 18 (52.9) 26 (59.1) 17
27 (4.0) 0 (0.0) 0 (0.0) 3 (8.8) 1 (2.3) 0
37 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
45 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
55 (14.0) 7 (17.5) 3 (9.1) 6 (17.6) 7 (15.9) 9
69 (2.0) 2 (5.0) 0 (0.0) 3 (8.8) 6 (13.6) 1
98 (24.0) 11 (27.5) 1 (3.0) 9 (26.5) 15 (34.1) 7
99 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 1 (2.3) 0
101 (12.0) 2 (5.0) 1 (3.0) 5 (14.7) 5 (11.4) 3
102 (2.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
103 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
104 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
105 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 1 (2.3) 0
115 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
116 (10.0) 1 (2.5) 0 (0.0) 1 (2.9) 4 (9.1) 2
118 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
127 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 0
128 (4.0) 1 (2.5) 1 (3.0) 0 (0.0) 0 (0.0) 1
71 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
72 (2.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
91 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
136 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
Totalprop_1 Totaln_2 Totalprop_2 Totaln_3 Totalprop_3 order
96 <NA> 84 <NA> 84 <NA> 1
138 (51.2) 73 (86.9) 70 (83.3) 100
137 (48.8) 11 (13.1) 14 (16.7) 200
1 <NA> NA <NA> NA <NA> 900
33 (7.0) 7 (8.3) 4 (4.8) 1000
22 (1.2) 0 (0.0) 2 (2.4) 1021
23 (0.0) 1 (1.2) 0 (0.0) 1022
24 (1.2) 0 (0.0) 0 (0.0) 1023
25 (1.2) 0 (0.0) 0 (0.0) 1024
30 (1.2) 0 (0.0) 0 (0.0) 1029
31 (0.0) 1 (1.2) 0 (0.0) 1030
34 (1.2) 0 (0.0) 0 (0.0) 1032
86 (2.3) 1 (1.2) 1 (1.2) 1075
93 (0.0) 1 (1.2) 0 (0.0) 1081
112 (1.2) 0 (0.0) 0 (0.0) 1095
113 (2.3) 2 (2.4) 0 (0.0) 1096
122 (0.0) 1 (1.2) 1 (1.2) 1104
129 (0.0) 1 (1.2) 0 (0.0) 1110
134 (0.0) 1 (1.2) 0 (0.0) 1115
40 (0.0) 1 (1.2) 0 (0.0) 2000
130 (0.0) 1 (1.2) 0 (0.0) 2111
50 (0.0) 2 (2.4) 1 (1.2) 3000
125 (0.0) 1 (1.2) 0 (0.0) 3107
131 (0.0) 1 (1.2) 1 (1.2) 3112
57 (0.0) 1 (1.2) 1 (1.2) 4000
132 (0.0) 1 (1.2) 1 (1.2) 4113
62 (4.7) 8 (9.5) 10 (11.9) 5000
2 (0.0) 1 (1.2) 1 (1.2) 5001
46 (3.5) 3 (3.6) 2 (2.4) 5043
48 (1.2) 1 (1.2) 0 (0.0) 5045
63 (1.2) 0 (0.0) 0 (0.0) 5057
87 (0.0) 3 (3.6) 3 (3.6) 5076
110 (0.0) 0 (0.0) 3 (3.6) 5093
120 (0.0) 0 (0.0) 1 (1.2) 5102
133 (0.0) 2 (2.4) 3 (3.6) 5114
64 (20.9) 43 (51.2) 35 (41.7) 6000
5 (0.0) 1 (1.2) 0 (0.0) 6004
6 (5.8) 9 (10.7) 7 (8.3) 6005
7 (0.0) 1 (1.2) 0 (0.0) 6006
8 (0.0) 0 (0.0) 1 (1.2) 6007
9 (0.0) 1 (1.2) 0 (0.0) 6008
10 (3.5) 12 (14.3) 15 (17.9) 6009
11 (1.2) 0 (0.0) 0 (0.0) 6010
12 (3.5) 9 (10.7) 9 (10.7) 6011
13 (0.0) 0 (0.0) 2 (2.4) 6012
14 (0.0) 0 (0.0) 2 (2.4) 6013
15 (7.0) 22 (26.2) 22 (26.2) 6014
16 (1.2) 0 (0.0) 1 (1.2) 6015
17 (0.0) 1 (1.2) 2 (2.4) 6016
18 (0.0) 2 (2.4) 1 (1.2) 6017
19 (1.2) 4 (4.8) 6 (7.1) 6018
20 (0.0) 1 (1.2) 0 (0.0) 6019
21 (1.2) 0 (0.0) 0 (0.0) 6020
35 (0.0) 0 (0.0) 1 (1.2) 6033
36 (1.2) 1 (1.2) 0 (0.0) 6034
59 (1.2) 2 (2.4) 4 (4.8) 6054
60 (0.0) 0 (0.0) 1 (1.2) 6055
81 (0.0) 1 (1.2) 1 (1.2) 6072
89 (0.0) 2 (2.4) 0 (0.0) 6077
90 (0.0) 0 (0.0) 1 (1.2) 6078
92 (0.0) 1 (1.2) 1 (1.2) 6080
74 (0.0) 2 (2.4) 1 (1.2) 7000
56 (0.0) 0 (0.0) 1 (1.2) 7052
58 (0.0) 1 (1.2) 0 (0.0) 7053
117 (0.0) 1 (1.2) 0 (0.0) 7099
135 (0.0) 1 (1.2) 0 (0.0) 7116
76 (4.7) 2 (2.4) 1 (1.2) 8000
28 (1.2) 0 (0.0) 0 (0.0) 8027
29 (0.0) 1 (1.2) 0 (0.0) 8028
51 (1.2) 1 (1.2) 0 (0.0) 8047
52 (0.0) 0 (0.0) 1 (1.2) 8048
67 (1.2) 0 (0.0) 0 (0.0) 8060
68 (1.2) 0 (0.0) 0 (0.0) 8061
82 (3.5) 0 (0.0) 1 (1.2) 9000
42 (1.2) 0 (0.0) 1 (1.2) 9039
61 (1.2) 0 (0.0) 0 (0.0) 9056
73 (1.2) 0 (0.0) 0 (0.0) 9066
84 (1.2) 0 (0.0) 1 (1.2) 10000
85 (0.0) 0 (0.0) 1 (1.2) 10074
111 (1.2) 0 (0.0) 0 (0.0) 10094
88 (5.8) 12 (14.3) 15 (17.9) 11000
26 (0.0) 1 (1.2) 0 (0.0) 11025
32 (0.0) 0 (0.0) 2 (2.4) 11031
38 (0.0) 1 (1.2) 0 (0.0) 11036
41 (0.0) 1 (1.2) 0 (0.0) 11038
47 (2.3) 6 (7.1) 6 (7.1) 11044
66 (2.3) 1 (1.2) 1 (1.2) 11059
70 (0.0) 0 (0.0) 1 (1.2) 11063
78 (0.0) 1 (1.2) 1 (1.2) 11069
94 (0.0) 1 (1.2) 0 (0.0) 11082
95 (0.0) 0 (0.0) 1 (1.2) 11083
119 (1.2) 0 (0.0) 0 (0.0) 11101
121 (0.0) 1 (1.2) 0 (0.0) 11103
123 (0.0) 4 (4.8) 3 (3.6) 11105
124 (0.0) 0 (0.0) 1 (1.2) 11106
126 (0.0) 1 (1.2) 0 (0.0) 11108
100 (2.3) 9 (10.7) 5 (6.0) 12000
3 (0.0) 2 (2.4) 0 (0.0) 12002
4 (0.0) 3 (3.6) 0 (0.0) 12003
39 (1.2) 2 (2.4) 0 (0.0) 12037
43 (0.0) 0 (0.0) 1 (1.2) 12040
44 (0.0) 1 (1.2) 0 (0.0) 12041
65 (0.0) 0 (0.0) 1 (1.2) 12058
75 (0.0) 0 (0.0) 2 (2.4) 12067
77 (1.2) 1 (1.2) 0 (0.0) 12068
79 (0.0) 0 (0.0) 1 (1.2) 12070
80 (0.0) 0 (0.0) 1 (1.2) 12071
109 (0.0) 1 (1.2) 0 (0.0) 12092
106 (0.0) 1 (1.2) 1 (1.2) 13000
54 (0.0) 1 (1.2) 0 (0.0) 13050
83 (0.0) 0 (0.0) 1 (1.2) 13073
107 (1.2) 0 (0.0) 0 (0.0) 14000
97 (1.2) 0 (0.0) 0 (0.0) 14084
108 (2.3) 0 (0.0) 0 (0.0) 15000
49 (1.2) 0 (0.0) 0 (0.0) 15046
53 (1.2) 0 (0.0) 0 (0.0) 15049
114 (19.8) 39 (46.4) 39 (46.4) 16000
27 (0.0) 5 (6.0) 1 (1.2) 16026
37 (1.2) 0 (0.0) 0 (0.0) 16035
45 (0.0) 1 (1.2) 0 (0.0) 16042
55 (10.5) 13 (15.5) 14 (16.7) 16051
69 (1.2) 4 (4.8) 8 (9.5) 16062
98 (8.1) 21 (25.0) 26 (31.0) 16085
99 (0.0) 1 (1.2) 1 (1.2) 16086
101 (3.5) 11 (13.1) 7 (8.3) 16087
102 (0.0) 2 (2.4) 0 (0.0) 16088
103 (0.0) 0 (0.0) 1 (1.2) 16089
104 (0.0) 0 (0.0) 1 (1.2) 16090
105 (0.0) 1 (1.2) 2 (2.4) 16091
115 (0.0) 1 (1.2) 0 (0.0) 16097
116 (2.3) 6 (7.1) 5 (6.0) 16098
118 (1.2) 0 (0.0) 0 (0.0) 16100
127 (0.0) 1 (1.2) 1 (1.2) 16109
128 (1.2) 2 (2.4) 1 (1.2) 17000
71 (0.0) 1 (1.2) 0 (0.0) 17064
72 (1.2) 1 (1.2) 0 (0.0) 17065
91 (1.2) 0 (0.0) 0 (0.0) 17079
136 (0.0) 0 (0.0) 1 (1.2) 17117
$display
[1] "n" "prop"
$rtf
name Fn_1 Fprop_1 Fn_2
96 Participants in population 53 <NA> 50
138 with one or more drug-related adverse events 28 (52.8) 41
137 with no drug-related adverse events 25 (47.2) 9
1 <NA> <NA> <NA>
33 Cardiac disorders 4 (7.5) 4
22 Atrial fibrillation 1 (1.9) 0
23 Atrial flutter 0 (0.0) 0
24 Atrioventricular block first degree 1 (1.9) 0
25 Atrioventricular block second degree 0 (0.0) 0
30 Bradycardia 1 (1.9) 0
31 Bundle branch block right 0 (0.0) 0
34 Cardiac failure congestive 1 (1.9) 0
86 Myocardial infarction 2 (3.8) 1
93 Palpitations 0 (0.0) 0
112 Sinus arrhythmia 0 (0.0) 0
113 Sinus bradycardia 2 (3.8) 1
122 Supraventricular extrasystoles 0 (0.0) 1
129 Ventricular extrasystoles 0 (0.0) 1
134 Wolff-parkinson-white syndrome 0 (0.0) 1
40 Congenital, familial and genetic disorders 0 (0.0) 0
130 Ventricular septal defect 0 (0.0) 0
50 Ear and labyrinth disorders 0 (0.0) 2
125 Tinnitus 0 (0.0) 1
131 Vertigo 0 (0.0) 1
57 Eye disorders 0 (0.0) 0
132 Vision blurred 0 (0.0) 0
62 Gastrointestinal disorders 1 (1.9) 6
2 Abdominal pain 0 (0.0) 1
46 Diarrhoea 0 (0.0) 3
48 Dyspepsia 1 (1.9) 0
63 Gastrooesophageal reflux disease 1 (1.9) 0
87 Nausea 0 (0.0) 2
110 Salivary hypersecretion 0 (0.0) 0
120 Stomach discomfort 0 (0.0) 0
133 Vomiting 0 (0.0) 2
64 General disorders and administration site conditions 11 (20.8) 23
5 Application site bleeding 0 (0.0) 1
6 Application site dermatitis 2 (3.8) 5
7 Application site desquamation 0 (0.0) 0
8 Application site discharge 0 (0.0) 0
9 Application site discolouration 0 (0.0) 0
10 Application site erythema 2 (3.8) 5
11 Application site induration 0 (0.0) 0
12 Application site irritation 3 (5.7) 6
13 Application site pain 0 (0.0) 0
14 Application site perspiration 0 (0.0) 0
15 Application site pruritus 4 (7.5) 12
16 Application site reaction 0 (0.0) 0
17 Application site swelling 0 (0.0) 0
18 Application site urticaria 0 (0.0) 0
19 Application site vesicles 0 (0.0) 1
20 Application site warmth 0 (0.0) 1
21 Asthenia 1 (1.9) 0
35 Chest discomfort 0 (0.0) 0
36 Chills 0 (0.0) 0
59 Fatigue 1 (1.9) 1
60 Feeling abnormal 0 (0.0) 0
81 Malaise 0 (0.0) 0
89 Oedema 0 (0.0) 1
90 Oedema peripheral 0 (0.0) 0
92 Pain 0 (0.0) 1
74 Injury, poisoning and procedural complications 0 (0.0) 2
56 Excoriation 0 (0.0) 0
58 Fall 0 (0.0) 1
117 Skin laceration 0 (0.0) 1
135 Wound 0 (0.0) 1
76 Investigations 2 (3.8) 2
28 Blood creatine phosphokinase increased 0 (0.0) 0
29 Body temperature increased 0 (0.0) 1
51 Electrocardiogram st segment depression 1 (1.9) 1
52 Electrocardiogram t wave inversion 0 (0.0) 0
67 Heart rate increased 0 (0.0) 0
68 Heart rate irregular 1 (1.9) 0
82 Metabolism and nutrition disorders 3 (5.7) 0
42 Decreased appetite 1 (1.9) 0
61 Food craving 1 (1.9) 0
73 Increased appetite 1 (1.9) 0
84 Musculoskeletal and connective tissue disorders 0 (0.0) 0
85 Myalgia 0 (0.0) 0
111 Shoulder pain 0 (0.0) 0
88 Nervous system disorders 3 (5.7) 8
26 Balance disorder 0 (0.0) 1
32 Burning sensation 0 (0.0) 0
38 Complex partial seizures 0 (0.0) 1
41 Coordination abnormal 0 (0.0) 1
47 Dizziness 1 (1.9) 3
66 Headache 2 (3.8) 0
70 Hypersomnia 0 (0.0) 0
78 Lethargy 0 (0.0) 0
94 Paraesthesia oral 0 (0.0) 1
95 Parosmia 0 (0.0) 0
119 Somnolence 0 (0.0) 0
121 Stupor 0 (0.0) 0
123 Syncope 0 (0.0) 4
124 Syncope vasovagal 0 (0.0) 0
126 Transient ischaemic attack 0 (0.0) 0
100 Psychiatric disorders 1 (1.9) 6
3 Agitation 0 (0.0) 2
4 Anxiety 0 (0.0) 3
39 Confusional state 0 (0.0) 1
43 Delirium 0 (0.0) 0
44 Depressed mood 0 (0.0) 0
65 Hallucination, visual 0 (0.0) 0
75 Insomnia 0 (0.0) 0
77 Irritability 1 (1.9) 1
79 Libido decreased 0 (0.0) 0
80 Listless 0 (0.0) 0
109 Restlessness 0 (0.0) 0
106 Renal and urinary disorders 0 (0.0) 1
54 Enuresis 0 (0.0) 1
83 Micturition urgency 0 (0.0) 0
107 Reproductive system and breast disorders 1 (1.9) 0
97 Pelvic pain 1 (1.9) 0
108 Respiratory, thoracic and mediastinal disorders 2 (3.8) 0
49 Dyspnoea 1 (1.9) 0
53 Emphysema 1 (1.9) 0
114 Skin and subcutaneous tissue disorders 12 (22.6) 21
27 Blister 0 (0.0) 2
37 Cold sweat 0 (0.0) 0
45 Dermatitis contact 0 (0.0) 0
55 Erythema 6 (11.3) 7
69 Hyperhidrosis 1 (1.9) 1
98 Pruritus 6 (11.3) 12
99 Pruritus generalised 0 (0.0) 0
101 Rash 2 (3.8) 6
102 Rash erythematous 0 (0.0) 1
103 Rash maculo-papular 0 (0.0) 0
104 Rash papular 0 (0.0) 0
105 Rash pruritic 0 (0.0) 1
115 Skin exfoliation 0 (0.0) 1
116 Skin irritation 2 (3.8) 5
118 Skin ulcer 0 (0.0) 0
127 Urticaria 0 (0.0) 0
128 Vascular disorders 0 (0.0) 2
71 Hypertension 0 (0.0) 1
72 Hypotension 0 (0.0) 1
91 Orthostatic hypotension 0 (0.0) 0
136 Wound haemorrhage 0 (0.0) 0
Fprop_2 Fn_3 Fprop_3 Mn_1 Mprop_1 Mn_2 Mprop_2 Mn_3 Mprop_3 Totaln_1
96 <NA> 40 <NA> 33 <NA> 34 <NA> 44 <NA> 86
138 (82.0) 32 (80.0) 16 (48.5) 32 (94.1) 38 (86.4) 44
137 (18.0) 8 (20.0) 17 (51.5) 2 (5.9) 6 (13.6) 42
1 <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA>
33 (8.0) 4 (10.0) 2 (6.1) 3 (8.8) 0 (0.0) 6
22 (0.0) 2 (5.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
23 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
24 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
25 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
30 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
31 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
34 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
86 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 2
93 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
112 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
113 (2.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 2
122 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
129 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
134 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
40 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
130 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
50 (4.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
125 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
131 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
57 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 0
132 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 0
62 (12.0) 3 (7.5) 3 (9.1) 2 (5.9) 7 (15.9) 4
2 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
46 (6.0) 0 (0.0) 3 (9.1) 0 (0.0) 2 (4.5) 3
48 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 1
63 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
87 (4.0) 2 (5.0) 0 (0.0) 1 (2.9) 1 (2.3) 0
110 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 3 (6.8) 0
120 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
133 (4.0) 0 (0.0) 0 (0.0) 0 (0.0) 3 (6.8) 0
64 (46.0) 17 (42.5) 7 (21.2) 20 (58.8) 18 (40.9) 18
5 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
6 (10.0) 4 (10.0) 3 (9.1) 4 (11.8) 3 (6.8) 5
7 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
8 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
9 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
10 (10.0) 5 (12.5) 1 (3.0) 7 (20.6) 10 (22.7) 3
11 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
12 (12.0) 5 (12.5) 0 (0.0) 3 (8.8) 4 (9.1) 3
13 (0.0) 2 (5.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
14 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (4.5) 0
15 (24.0) 10 (25.0) 2 (6.1) 10 (29.4) 12 (27.3) 6
16 (0.0) 1 (2.5) 1 (3.0) 0 (0.0) 0 (0.0) 1
17 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 1 (2.3) 0
18 (0.0) 1 (2.5) 0 (0.0) 2 (5.9) 0 (0.0) 0
19 (2.0) 3 (7.5) 1 (3.0) 3 (8.8) 3 (6.8) 1
20 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
21 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
35 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
36 (0.0) 0 (0.0) 1 (3.0) 1 (2.9) 0 (0.0) 1
59 (2.0) 4 (10.0) 0 (0.0) 1 (2.9) 0 (0.0) 1
60 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
81 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 1 (2.3) 0
89 (2.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
90 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
92 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
74 (4.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
56 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
58 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
117 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
135 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
76 (4.0) 1 (2.5) 2 (6.1) 0 (0.0) 0 (0.0) 4
28 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
29 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
51 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
52 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
67 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
68 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
82 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 3
42 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 1
61 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
73 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
84 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 1 (2.3) 1
85 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
111 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
88 (16.0) 7 (17.5) 2 (6.1) 4 (11.8) 8 (18.2) 5
26 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
32 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (4.5) 0
38 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
41 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
47 (6.0) 2 (5.0) 1 (3.0) 3 (8.8) 4 (9.1) 2
66 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 2
70 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
78 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 0
94 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
95 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
119 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
121 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
123 (8.0) 2 (5.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
124 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
126 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
100 (12.0) 1 (2.5) 1 (3.0) 3 (8.8) 4 (9.1) 2
3 (4.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
4 (6.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
39 (2.0) 0 (0.0) 1 (3.0) 1 (2.9) 0 (0.0) 1
43 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
44 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
65 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
75 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (4.5) 0
77 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
79 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
80 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
109 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
106 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
54 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
83 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
107 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
97 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
108 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2
49 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
53 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
114 (42.0) 13 (32.5) 5 (15.2) 18 (52.9) 26 (59.1) 17
27 (4.0) 0 (0.0) 0 (0.0) 3 (8.8) 1 (2.3) 0
37 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
45 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
55 (14.0) 7 (17.5) 3 (9.1) 6 (17.6) 7 (15.9) 9
69 (2.0) 2 (5.0) 0 (0.0) 3 (8.8) 6 (13.6) 1
98 (24.0) 11 (27.5) 1 (3.0) 9 (26.5) 15 (34.1) 7
99 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 1 (2.3) 0
101 (12.0) 2 (5.0) 1 (3.0) 5 (14.7) 5 (11.4) 3
102 (2.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
103 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
104 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
105 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 1 (2.3) 0
115 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
116 (10.0) 1 (2.5) 0 (0.0) 1 (2.9) 4 (9.1) 2
118 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
127 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 0
128 (4.0) 1 (2.5) 1 (3.0) 0 (0.0) 0 (0.0) 1
71 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
72 (2.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
91 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
136 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
Totalprop_1 Totaln_2 Totalprop_2 Totaln_3 Totalprop_3
96 <NA> 84 <NA> 84 <NA>
138 (51.2) 73 (86.9) 70 (83.3)
137 (48.8) 11 (13.1) 14 (16.7)
1 <NA> <NA> <NA> <NA> <NA>
33 (7.0) 7 (8.3) 4 (4.8)
22 (1.2) 0 (0.0) 2 (2.4)
23 (0.0) 1 (1.2) 0 (0.0)
24 (1.2) 0 (0.0) 0 (0.0)
25 (1.2) 0 (0.0) 0 (0.0)
30 (1.2) 0 (0.0) 0 (0.0)
31 (0.0) 1 (1.2) 0 (0.0)
34 (1.2) 0 (0.0) 0 (0.0)
86 (2.3) 1 (1.2) 1 (1.2)
93 (0.0) 1 (1.2) 0 (0.0)
112 (1.2) 0 (0.0) 0 (0.0)
113 (2.3) 2 (2.4) 0 (0.0)
122 (0.0) 1 (1.2) 1 (1.2)
129 (0.0) 1 (1.2) 0 (0.0)
134 (0.0) 1 (1.2) 0 (0.0)
40 (0.0) 1 (1.2) 0 (0.0)
130 (0.0) 1 (1.2) 0 (0.0)
50 (0.0) 2 (2.4) 1 (1.2)
125 (0.0) 1 (1.2) 0 (0.0)
131 (0.0) 1 (1.2) 1 (1.2)
57 (0.0) 1 (1.2) 1 (1.2)
132 (0.0) 1 (1.2) 1 (1.2)
62 (4.7) 8 (9.5) 10 (11.9)
2 (0.0) 1 (1.2) 1 (1.2)
46 (3.5) 3 (3.6) 2 (2.4)
48 (1.2) 1 (1.2) 0 (0.0)
63 (1.2) 0 (0.0) 0 (0.0)
87 (0.0) 3 (3.6) 3 (3.6)
110 (0.0) 0 (0.0) 3 (3.6)
120 (0.0) 0 (0.0) 1 (1.2)
133 (0.0) 2 (2.4) 3 (3.6)
64 (20.9) 43 (51.2) 35 (41.7)
5 (0.0) 1 (1.2) 0 (0.0)
6 (5.8) 9 (10.7) 7 (8.3)
7 (0.0) 1 (1.2) 0 (0.0)
8 (0.0) 0 (0.0) 1 (1.2)
9 (0.0) 1 (1.2) 0 (0.0)
10 (3.5) 12 (14.3) 15 (17.9)
11 (1.2) 0 (0.0) 0 (0.0)
12 (3.5) 9 (10.7) 9 (10.7)
13 (0.0) 0 (0.0) 2 (2.4)
14 (0.0) 0 (0.0) 2 (2.4)
15 (7.0) 22 (26.2) 22 (26.2)
16 (1.2) 0 (0.0) 1 (1.2)
17 (0.0) 1 (1.2) 2 (2.4)
18 (0.0) 2 (2.4) 1 (1.2)
19 (1.2) 4 (4.8) 6 (7.1)
20 (0.0) 1 (1.2) 0 (0.0)
21 (1.2) 0 (0.0) 0 (0.0)
35 (0.0) 0 (0.0) 1 (1.2)
36 (1.2) 1 (1.2) 0 (0.0)
59 (1.2) 2 (2.4) 4 (4.8)
60 (0.0) 0 (0.0) 1 (1.2)
81 (0.0) 1 (1.2) 1 (1.2)
89 (0.0) 2 (2.4) 0 (0.0)
90 (0.0) 0 (0.0) 1 (1.2)
92 (0.0) 1 (1.2) 1 (1.2)
74 (0.0) 2 (2.4) 1 (1.2)
56 (0.0) 0 (0.0) 1 (1.2)
58 (0.0) 1 (1.2) 0 (0.0)
117 (0.0) 1 (1.2) 0 (0.0)
135 (0.0) 1 (1.2) 0 (0.0)
76 (4.7) 2 (2.4) 1 (1.2)
28 (1.2) 0 (0.0) 0 (0.0)
29 (0.0) 1 (1.2) 0 (0.0)
51 (1.2) 1 (1.2) 0 (0.0)
52 (0.0) 0 (0.0) 1 (1.2)
67 (1.2) 0 (0.0) 0 (0.0)
68 (1.2) 0 (0.0) 0 (0.0)
82 (3.5) 0 (0.0) 1 (1.2)
42 (1.2) 0 (0.0) 1 (1.2)
61 (1.2) 0 (0.0) 0 (0.0)
73 (1.2) 0 (0.0) 0 (0.0)
84 (1.2) 0 (0.0) 1 (1.2)
85 (0.0) 0 (0.0) 1 (1.2)
111 (1.2) 0 (0.0) 0 (0.0)
88 (5.8) 12 (14.3) 15 (17.9)
26 (0.0) 1 (1.2) 0 (0.0)
32 (0.0) 0 (0.0) 2 (2.4)
38 (0.0) 1 (1.2) 0 (0.0)
41 (0.0) 1 (1.2) 0 (0.0)
47 (2.3) 6 (7.1) 6 (7.1)
66 (2.3) 1 (1.2) 1 (1.2)
70 (0.0) 0 (0.0) 1 (1.2)
78 (0.0) 1 (1.2) 1 (1.2)
94 (0.0) 1 (1.2) 0 (0.0)
95 (0.0) 0 (0.0) 1 (1.2)
119 (1.2) 0 (0.0) 0 (0.0)
121 (0.0) 1 (1.2) 0 (0.0)
123 (0.0) 4 (4.8) 3 (3.6)
124 (0.0) 0 (0.0) 1 (1.2)
126 (0.0) 1 (1.2) 0 (0.0)
100 (2.3) 9 (10.7) 5 (6.0)
3 (0.0) 2 (2.4) 0 (0.0)
4 (0.0) 3 (3.6) 0 (0.0)
39 (1.2) 2 (2.4) 0 (0.0)
43 (0.0) 0 (0.0) 1 (1.2)
44 (0.0) 1 (1.2) 0 (0.0)
65 (0.0) 0 (0.0) 1 (1.2)
75 (0.0) 0 (0.0) 2 (2.4)
77 (1.2) 1 (1.2) 0 (0.0)
79 (0.0) 0 (0.0) 1 (1.2)
80 (0.0) 0 (0.0) 1 (1.2)
109 (0.0) 1 (1.2) 0 (0.0)
106 (0.0) 1 (1.2) 1 (1.2)
54 (0.0) 1 (1.2) 0 (0.0)
83 (0.0) 0 (0.0) 1 (1.2)
107 (1.2) 0 (0.0) 0 (0.0)
97 (1.2) 0 (0.0) 0 (0.0)
108 (2.3) 0 (0.0) 0 (0.0)
49 (1.2) 0 (0.0) 0 (0.0)
53 (1.2) 0 (0.0) 0 (0.0)
114 (19.8) 39 (46.4) 39 (46.4)
27 (0.0) 5 (6.0) 1 (1.2)
37 (1.2) 0 (0.0) 0 (0.0)
45 (0.0) 1 (1.2) 0 (0.0)
55 (10.5) 13 (15.5) 14 (16.7)
69 (1.2) 4 (4.8) 8 (9.5)
98 (8.1) 21 (25.0) 26 (31.0)
99 (0.0) 1 (1.2) 1 (1.2)
101 (3.5) 11 (13.1) 7 (8.3)
102 (0.0) 2 (2.4) 0 (0.0)
103 (0.0) 0 (0.0) 1 (1.2)
104 (0.0) 0 (0.0) 1 (1.2)
105 (0.0) 1 (1.2) 2 (2.4)
115 (0.0) 1 (1.2) 0 (0.0)
116 (2.3) 6 (7.1) 5 (6.0)
118 (1.2) 0 (0.0) 0 (0.0)
127 (0.0) 1 (1.2) 1 (1.2)
128 (1.2) 2 (2.4) 1 (1.2)
71 (0.0) 1 (1.2) 0 (0.0)
72 (1.2) 1 (1.2) 0 (0.0)
91 (1.2) 0 (0.0) 0 (0.0)
136 (0.0) 0 (0.0) 1 (1.2)
Merck/metalite.ae documentation built on Feb. 10, 2025, 5:03 p.m.
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rtf output: n, and prop w/o total
Code
tbl
Output
$components
[1] "soc" "par"
$group
[1] "Placebo" "Low Dose" "High Dose"
$subgroup
[1] "f" "m"
$display_subgroup_total
[1] TRUE
$meta
ADaM metadata:
.$data_population Population data with 254 subjects
.$data_observation Observation data with 1191 records
.$plan Analysis plan with 18 plans
Analysis population type:
name id group var subset label
1 'apat' 'USUBJID' 'TRTA' SAFFL == 'Y' 'All Participants as Treated'
Analysis observation type:
name id group var subset label
1 'wk12' 'USUBJID' 'TRTA' SAFFL == 'Y' 'Weeks 0 to 12'
2 'wk24' 'USUBJID' 'TRTA' AOCC01FL == 'Y' 'Weeks 0 to 24'
Analysis parameter type:
name label
1 'rel' 'drug-related adverse events'
2 'aeosi' 'adverse events of special interest'
3 'any' 'any adverse events'
4 'ser' 'serious adverse events'
subset
1 AEREL %in% c('POSSIBLE', 'PROBABLE')
2 AEOSI == 'Y'
3
4 AESER == 'Y'
Analysis function:
name label
1 'ae_summary' 'Table: adverse event summary'
2 'ae_listing' 'Listing: adverse event'
3 'ae_exp_adj' 'Exposure Adjusted Incident Rate'
4 'ae_specific' 'Table: specific adverse event'
$population
[1] "apat"
$observation
[1] "wk12"
$parameter
[1] "rel"
$out_all
$out_all$F
List of 15
$ meta :List of 7
$ population : chr "apat"
$ observation : chr "wk12"
$ parameter : chr "rel"
$ n :'data.frame': 138 obs. of 4 variables:
$ order : num [1:138] 1 100 200 900 1000 ...
$ group : chr [1:4] "Placebo" "Low Dose" "High Dose" "Total"
$ reference_group: num 1
$ prop :'data.frame': 138 obs. of 4 variables:
$ diff :'data.frame': 138 obs. of 2 variables:
$ n_pop :'data.frame': 1 obs. of 4 variables:
$ name : chr [1:138] "Participants in population" "with one or more drug-related adverse events" "with no drug-related adverse events" "" ...
$ soc_name : chr [1:138] NA NA NA NA ...
$ components : chr [1:2] "soc" "par"
$ prepare_call : language FUN(meta = X[[i]], population = ..1, observation = ..2, parameter = ..3, components = ..4)
$out_all$M
List of 15
$ meta :List of 7
$ population : chr "apat"
$ observation : chr "wk12"
$ parameter : chr "rel"
$ n :'data.frame': 138 obs. of 4 variables:
$ order : num [1:138] 1 100 200 900 1000 ...
$ group : chr [1:4] "Placebo" "Low Dose" "High Dose" "Total"
$ reference_group: num 1
$ prop :'data.frame': 138 obs. of 4 variables:
$ diff :'data.frame': 138 obs. of 2 variables:
$ n_pop :'data.frame': 1 obs. of 4 variables:
$ name : chr [1:138] "Participants in population" "with one or more drug-related adverse events" "with no drug-related adverse events" "" ...
$ soc_name : chr [1:138] NA NA NA NA ...
$ components : chr [1:2] "soc" "par"
$ prepare_call : language FUN(meta = X[[i]], population = ..1, observation = ..2, parameter = ..3, components = ..4)
$out_all$Total
List of 15
$ meta :List of 7
$ population : chr "apat"
$ observation : chr "wk12"
$ parameter : chr "rel"
$ n :'data.frame': 138 obs. of 4 variables:
$ order : num [1:138] 1 100 200 900 1000 ...
$ group : chr [1:4] "Placebo" "Low Dose" "High Dose" "Total"
$ reference_group: num 1
$ prop :'data.frame': 138 obs. of 4 variables:
$ diff :'data.frame': 138 obs. of 2 variables:
$ n_pop :'data.frame': 1 obs. of 4 variables:
$ name : chr [1:138] "Participants in population" "with one or more drug-related adverse events" "with no drug-related adverse events" "" ...
$ soc_name : chr [1:138] NA NA NA NA ...
$ components : chr [1:2] "soc" "par"
$ prepare_call : language prepare_ae_specific(meta = meta, population = population, observation = observation, parameter = parameter, | __truncated__
$tbl
name Fn_1 Fprop_1 Fn_2
96 Participants in population 53 <NA> 50
138 with one or more drug-related adverse events 28 (52.8) 41
137 with no drug-related adverse events 25 (47.2) 9
1 NA <NA> NA
33 Cardiac disorders 4 (7.5) 4
22 Atrial fibrillation 1 (1.9) 0
23 Atrial flutter 0 (0.0) 0
24 Atrioventricular block first degree 1 (1.9) 0
25 Atrioventricular block second degree 0 (0.0) 0
30 Bradycardia 1 (1.9) 0
31 Bundle branch block right 0 (0.0) 0
34 Cardiac failure congestive 1 (1.9) 0
86 Myocardial infarction 2 (3.8) 1
93 Palpitations 0 (0.0) 0
112 Sinus arrhythmia 0 (0.0) 0
113 Sinus bradycardia 2 (3.8) 1
122 Supraventricular extrasystoles 0 (0.0) 1
129 Ventricular extrasystoles 0 (0.0) 1
134 Wolff-parkinson-white syndrome 0 (0.0) 1
40 Congenital, familial and genetic disorders 0 (0.0) 0
130 Ventricular septal defect 0 (0.0) 0
50 Ear and labyrinth disorders 0 (0.0) 2
125 Tinnitus 0 (0.0) 1
131 Vertigo 0 (0.0) 1
57 Eye disorders 0 (0.0) 0
132 Vision blurred 0 (0.0) 0
62 Gastrointestinal disorders 1 (1.9) 6
2 Abdominal pain 0 (0.0) 1
46 Diarrhoea 0 (0.0) 3
48 Dyspepsia 1 (1.9) 0
63 Gastrooesophageal reflux disease 1 (1.9) 0
87 Nausea 0 (0.0) 2
110 Salivary hypersecretion 0 (0.0) 0
120 Stomach discomfort 0 (0.0) 0
133 Vomiting 0 (0.0) 2
64 General disorders and administration site conditions 11 (20.8) 23
5 Application site bleeding 0 (0.0) 1
6 Application site dermatitis 2 (3.8) 5
7 Application site desquamation 0 (0.0) 0
8 Application site discharge 0 (0.0) 0
9 Application site discolouration 0 (0.0) 0
10 Application site erythema 2 (3.8) 5
11 Application site induration 0 (0.0) 0
12 Application site irritation 3 (5.7) 6
13 Application site pain 0 (0.0) 0
14 Application site perspiration 0 (0.0) 0
15 Application site pruritus 4 (7.5) 12
16 Application site reaction 0 (0.0) 0
17 Application site swelling 0 (0.0) 0
18 Application site urticaria 0 (0.0) 0
19 Application site vesicles 0 (0.0) 1
20 Application site warmth 0 (0.0) 1
21 Asthenia 1 (1.9) 0
35 Chest discomfort 0 (0.0) 0
36 Chills 0 (0.0) 0
59 Fatigue 1 (1.9) 1
60 Feeling abnormal 0 (0.0) 0
81 Malaise 0 (0.0) 0
89 Oedema 0 (0.0) 1
90 Oedema peripheral 0 (0.0) 0
92 Pain 0 (0.0) 1
74 Injury, poisoning and procedural complications 0 (0.0) 2
56 Excoriation 0 (0.0) 0
58 Fall 0 (0.0) 1
117 Skin laceration 0 (0.0) 1
135 Wound 0 (0.0) 1
76 Investigations 2 (3.8) 2
28 Blood creatine phosphokinase increased 0 (0.0) 0
29 Body temperature increased 0 (0.0) 1
51 Electrocardiogram st segment depression 1 (1.9) 1
52 Electrocardiogram t wave inversion 0 (0.0) 0
67 Heart rate increased 0 (0.0) 0
68 Heart rate irregular 1 (1.9) 0
82 Metabolism and nutrition disorders 3 (5.7) 0
42 Decreased appetite 1 (1.9) 0
61 Food craving 1 (1.9) 0
73 Increased appetite 1 (1.9) 0
84 Musculoskeletal and connective tissue disorders 0 (0.0) 0
85 Myalgia 0 (0.0) 0
111 Shoulder pain 0 (0.0) 0
88 Nervous system disorders 3 (5.7) 8
26 Balance disorder 0 (0.0) 1
32 Burning sensation 0 (0.0) 0
38 Complex partial seizures 0 (0.0) 1
41 Coordination abnormal 0 (0.0) 1
47 Dizziness 1 (1.9) 3
66 Headache 2 (3.8) 0
70 Hypersomnia 0 (0.0) 0
78 Lethargy 0 (0.0) 0
94 Paraesthesia oral 0 (0.0) 1
95 Parosmia 0 (0.0) 0
119 Somnolence 0 (0.0) 0
121 Stupor 0 (0.0) 0
123 Syncope 0 (0.0) 4
124 Syncope vasovagal 0 (0.0) 0
126 Transient ischaemic attack 0 (0.0) 0
100 Psychiatric disorders 1 (1.9) 6
3 Agitation 0 (0.0) 2
4 Anxiety 0 (0.0) 3
39 Confusional state 0 (0.0) 1
43 Delirium 0 (0.0) 0
44 Depressed mood 0 (0.0) 0
65 Hallucination, visual 0 (0.0) 0
75 Insomnia 0 (0.0) 0
77 Irritability 1 (1.9) 1
79 Libido decreased 0 (0.0) 0
80 Listless 0 (0.0) 0
109 Restlessness 0 (0.0) 0
106 Renal and urinary disorders 0 (0.0) 1
54 Enuresis 0 (0.0) 1
83 Micturition urgency 0 (0.0) 0
107 Reproductive system and breast disorders 1 (1.9) 0
97 Pelvic pain 1 (1.9) 0
108 Respiratory, thoracic and mediastinal disorders 2 (3.8) 0
49 Dyspnoea 1 (1.9) 0
53 Emphysema 1 (1.9) 0
114 Skin and subcutaneous tissue disorders 12 (22.6) 21
27 Blister 0 (0.0) 2
37 Cold sweat 0 (0.0) 0
45 Dermatitis contact 0 (0.0) 0
55 Erythema 6 (11.3) 7
69 Hyperhidrosis 1 (1.9) 1
98 Pruritus 6 (11.3) 12
99 Pruritus generalised 0 (0.0) 0
101 Rash 2 (3.8) 6
102 Rash erythematous 0 (0.0) 1
103 Rash maculo-papular 0 (0.0) 0
104 Rash papular 0 (0.0) 0
105 Rash pruritic 0 (0.0) 1
115 Skin exfoliation 0 (0.0) 1
116 Skin irritation 2 (3.8) 5
118 Skin ulcer 0 (0.0) 0
127 Urticaria 0 (0.0) 0
128 Vascular disorders 0 (0.0) 2
71 Hypertension 0 (0.0) 1
72 Hypotension 0 (0.0) 1
91 Orthostatic hypotension 0 (0.0) 0
136 Wound haemorrhage 0 (0.0) 0
Fprop_2 Fn_3 Fprop_3 Mn_1 Mprop_1 Mn_2 Mprop_2 Mn_3 Mprop_3 Totaln_1
96 <NA> 40 <NA> 33 <NA> 34 <NA> 44 <NA> 86
138 (82.0) 32 (80.0) 16 (48.5) 32 (94.1) 38 (86.4) 44
137 (18.0) 8 (20.0) 17 (51.5) 2 (5.9) 6 (13.6) 42
1 <NA> NA <NA> NA <NA> NA <NA> NA <NA> NA
33 (8.0) 4 (10.0) 2 (6.1) 3 (8.8) 0 (0.0) 6
22 (0.0) 2 (5.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
23 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
24 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
25 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
30 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
31 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
34 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
86 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 2
93 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
112 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
113 (2.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 2
122 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
129 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
134 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
40 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
130 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
50 (4.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
125 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
131 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
57 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 0
132 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 0
62 (12.0) 3 (7.5) 3 (9.1) 2 (5.9) 7 (15.9) 4
2 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
46 (6.0) 0 (0.0) 3 (9.1) 0 (0.0) 2 (4.5) 3
48 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 1
63 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
87 (4.0) 2 (5.0) 0 (0.0) 1 (2.9) 1 (2.3) 0
110 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 3 (6.8) 0
120 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
133 (4.0) 0 (0.0) 0 (0.0) 0 (0.0) 3 (6.8) 0
64 (46.0) 17 (42.5) 7 (21.2) 20 (58.8) 18 (40.9) 18
5 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
6 (10.0) 4 (10.0) 3 (9.1) 4 (11.8) 3 (6.8) 5
7 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
8 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
9 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
10 (10.0) 5 (12.5) 1 (3.0) 7 (20.6) 10 (22.7) 3
11 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
12 (12.0) 5 (12.5) 0 (0.0) 3 (8.8) 4 (9.1) 3
13 (0.0) 2 (5.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
14 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (4.5) 0
15 (24.0) 10 (25.0) 2 (6.1) 10 (29.4) 12 (27.3) 6
16 (0.0) 1 (2.5) 1 (3.0) 0 (0.0) 0 (0.0) 1
17 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 1 (2.3) 0
18 (0.0) 1 (2.5) 0 (0.0) 2 (5.9) 0 (0.0) 0
19 (2.0) 3 (7.5) 1 (3.0) 3 (8.8) 3 (6.8) 1
20 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
21 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
35 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
36 (0.0) 0 (0.0) 1 (3.0) 1 (2.9) 0 (0.0) 1
59 (2.0) 4 (10.0) 0 (0.0) 1 (2.9) 0 (0.0) 1
60 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
81 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 1 (2.3) 0
89 (2.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
90 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
92 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
74 (4.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
56 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
58 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
117 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
135 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
76 (4.0) 1 (2.5) 2 (6.1) 0 (0.0) 0 (0.0) 4
28 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
29 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
51 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
52 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
67 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
68 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
82 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 3
42 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 1
61 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
73 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
84 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 1 (2.3) 1
85 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
111 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
88 (16.0) 7 (17.5) 2 (6.1) 4 (11.8) 8 (18.2) 5
26 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
32 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (4.5) 0
38 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
41 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
47 (6.0) 2 (5.0) 1 (3.0) 3 (8.8) 4 (9.1) 2
66 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 2
70 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
78 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 0
94 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
95 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
119 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
121 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
123 (8.0) 2 (5.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
124 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
126 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
100 (12.0) 1 (2.5) 1 (3.0) 3 (8.8) 4 (9.1) 2
3 (4.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
4 (6.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
39 (2.0) 0 (0.0) 1 (3.0) 1 (2.9) 0 (0.0) 1
43 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
44 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
65 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
75 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (4.5) 0
77 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
79 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
80 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
109 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
106 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
54 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
83 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
107 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
97 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
108 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2
49 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
53 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
114 (42.0) 13 (32.5) 5 (15.2) 18 (52.9) 26 (59.1) 17
27 (4.0) 0 (0.0) 0 (0.0) 3 (8.8) 1 (2.3) 0
37 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
45 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
55 (14.0) 7 (17.5) 3 (9.1) 6 (17.6) 7 (15.9) 9
69 (2.0) 2 (5.0) 0 (0.0) 3 (8.8) 6 (13.6) 1
98 (24.0) 11 (27.5) 1 (3.0) 9 (26.5) 15 (34.1) 7
99 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 1 (2.3) 0
101 (12.0) 2 (5.0) 1 (3.0) 5 (14.7) 5 (11.4) 3
102 (2.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
103 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
104 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
105 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 1 (2.3) 0
115 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
116 (10.0) 1 (2.5) 0 (0.0) 1 (2.9) 4 (9.1) 2
118 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
127 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 0
128 (4.0) 1 (2.5) 1 (3.0) 0 (0.0) 0 (0.0) 1
71 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
72 (2.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
91 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
136 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
Totalprop_1 Totaln_2 Totalprop_2 Totaln_3 Totalprop_3 order
96 <NA> 84 <NA> 84 <NA> 1
138 (51.2) 73 (86.9) 70 (83.3) 100
137 (48.8) 11 (13.1) 14 (16.7) 200
1 <NA> NA <NA> NA <NA> 900
33 (7.0) 7 (8.3) 4 (4.8) 1000
22 (1.2) 0 (0.0) 2 (2.4) 1021
23 (0.0) 1 (1.2) 0 (0.0) 1022
24 (1.2) 0 (0.0) 0 (0.0) 1023
25 (1.2) 0 (0.0) 0 (0.0) 1024
30 (1.2) 0 (0.0) 0 (0.0) 1029
31 (0.0) 1 (1.2) 0 (0.0) 1030
34 (1.2) 0 (0.0) 0 (0.0) 1032
86 (2.3) 1 (1.2) 1 (1.2) 1075
93 (0.0) 1 (1.2) 0 (0.0) 1081
112 (1.2) 0 (0.0) 0 (0.0) 1095
113 (2.3) 2 (2.4) 0 (0.0) 1096
122 (0.0) 1 (1.2) 1 (1.2) 1104
129 (0.0) 1 (1.2) 0 (0.0) 1110
134 (0.0) 1 (1.2) 0 (0.0) 1115
40 (0.0) 1 (1.2) 0 (0.0) 2000
130 (0.0) 1 (1.2) 0 (0.0) 2111
50 (0.0) 2 (2.4) 1 (1.2) 3000
125 (0.0) 1 (1.2) 0 (0.0) 3107
131 (0.0) 1 (1.2) 1 (1.2) 3112
57 (0.0) 1 (1.2) 1 (1.2) 4000
132 (0.0) 1 (1.2) 1 (1.2) 4113
62 (4.7) 8 (9.5) 10 (11.9) 5000
2 (0.0) 1 (1.2) 1 (1.2) 5001
46 (3.5) 3 (3.6) 2 (2.4) 5043
48 (1.2) 1 (1.2) 0 (0.0) 5045
63 (1.2) 0 (0.0) 0 (0.0) 5057
87 (0.0) 3 (3.6) 3 (3.6) 5076
110 (0.0) 0 (0.0) 3 (3.6) 5093
120 (0.0) 0 (0.0) 1 (1.2) 5102
133 (0.0) 2 (2.4) 3 (3.6) 5114
64 (20.9) 43 (51.2) 35 (41.7) 6000
5 (0.0) 1 (1.2) 0 (0.0) 6004
6 (5.8) 9 (10.7) 7 (8.3) 6005
7 (0.0) 1 (1.2) 0 (0.0) 6006
8 (0.0) 0 (0.0) 1 (1.2) 6007
9 (0.0) 1 (1.2) 0 (0.0) 6008
10 (3.5) 12 (14.3) 15 (17.9) 6009
11 (1.2) 0 (0.0) 0 (0.0) 6010
12 (3.5) 9 (10.7) 9 (10.7) 6011
13 (0.0) 0 (0.0) 2 (2.4) 6012
14 (0.0) 0 (0.0) 2 (2.4) 6013
15 (7.0) 22 (26.2) 22 (26.2) 6014
16 (1.2) 0 (0.0) 1 (1.2) 6015
17 (0.0) 1 (1.2) 2 (2.4) 6016
18 (0.0) 2 (2.4) 1 (1.2) 6017
19 (1.2) 4 (4.8) 6 (7.1) 6018
20 (0.0) 1 (1.2) 0 (0.0) 6019
21 (1.2) 0 (0.0) 0 (0.0) 6020
35 (0.0) 0 (0.0) 1 (1.2) 6033
36 (1.2) 1 (1.2) 0 (0.0) 6034
59 (1.2) 2 (2.4) 4 (4.8) 6054
60 (0.0) 0 (0.0) 1 (1.2) 6055
81 (0.0) 1 (1.2) 1 (1.2) 6072
89 (0.0) 2 (2.4) 0 (0.0) 6077
90 (0.0) 0 (0.0) 1 (1.2) 6078
92 (0.0) 1 (1.2) 1 (1.2) 6080
74 (0.0) 2 (2.4) 1 (1.2) 7000
56 (0.0) 0 (0.0) 1 (1.2) 7052
58 (0.0) 1 (1.2) 0 (0.0) 7053
117 (0.0) 1 (1.2) 0 (0.0) 7099
135 (0.0) 1 (1.2) 0 (0.0) 7116
76 (4.7) 2 (2.4) 1 (1.2) 8000
28 (1.2) 0 (0.0) 0 (0.0) 8027
29 (0.0) 1 (1.2) 0 (0.0) 8028
51 (1.2) 1 (1.2) 0 (0.0) 8047
52 (0.0) 0 (0.0) 1 (1.2) 8048
67 (1.2) 0 (0.0) 0 (0.0) 8060
68 (1.2) 0 (0.0) 0 (0.0) 8061
82 (3.5) 0 (0.0) 1 (1.2) 9000
42 (1.2) 0 (0.0) 1 (1.2) 9039
61 (1.2) 0 (0.0) 0 (0.0) 9056
73 (1.2) 0 (0.0) 0 (0.0) 9066
84 (1.2) 0 (0.0) 1 (1.2) 10000
85 (0.0) 0 (0.0) 1 (1.2) 10074
111 (1.2) 0 (0.0) 0 (0.0) 10094
88 (5.8) 12 (14.3) 15 (17.9) 11000
26 (0.0) 1 (1.2) 0 (0.0) 11025
32 (0.0) 0 (0.0) 2 (2.4) 11031
38 (0.0) 1 (1.2) 0 (0.0) 11036
41 (0.0) 1 (1.2) 0 (0.0) 11038
47 (2.3) 6 (7.1) 6 (7.1) 11044
66 (2.3) 1 (1.2) 1 (1.2) 11059
70 (0.0) 0 (0.0) 1 (1.2) 11063
78 (0.0) 1 (1.2) 1 (1.2) 11069
94 (0.0) 1 (1.2) 0 (0.0) 11082
95 (0.0) 0 (0.0) 1 (1.2) 11083
119 (1.2) 0 (0.0) 0 (0.0) 11101
121 (0.0) 1 (1.2) 0 (0.0) 11103
123 (0.0) 4 (4.8) 3 (3.6) 11105
124 (0.0) 0 (0.0) 1 (1.2) 11106
126 (0.0) 1 (1.2) 0 (0.0) 11108
100 (2.3) 9 (10.7) 5 (6.0) 12000
3 (0.0) 2 (2.4) 0 (0.0) 12002
4 (0.0) 3 (3.6) 0 (0.0) 12003
39 (1.2) 2 (2.4) 0 (0.0) 12037
43 (0.0) 0 (0.0) 1 (1.2) 12040
44 (0.0) 1 (1.2) 0 (0.0) 12041
65 (0.0) 0 (0.0) 1 (1.2) 12058
75 (0.0) 0 (0.0) 2 (2.4) 12067
77 (1.2) 1 (1.2) 0 (0.0) 12068
79 (0.0) 0 (0.0) 1 (1.2) 12070
80 (0.0) 0 (0.0) 1 (1.2) 12071
109 (0.0) 1 (1.2) 0 (0.0) 12092
106 (0.0) 1 (1.2) 1 (1.2) 13000
54 (0.0) 1 (1.2) 0 (0.0) 13050
83 (0.0) 0 (0.0) 1 (1.2) 13073
107 (1.2) 0 (0.0) 0 (0.0) 14000
97 (1.2) 0 (0.0) 0 (0.0) 14084
108 (2.3) 0 (0.0) 0 (0.0) 15000
49 (1.2) 0 (0.0) 0 (0.0) 15046
53 (1.2) 0 (0.0) 0 (0.0) 15049
114 (19.8) 39 (46.4) 39 (46.4) 16000
27 (0.0) 5 (6.0) 1 (1.2) 16026
37 (1.2) 0 (0.0) 0 (0.0) 16035
45 (0.0) 1 (1.2) 0 (0.0) 16042
55 (10.5) 13 (15.5) 14 (16.7) 16051
69 (1.2) 4 (4.8) 8 (9.5) 16062
98 (8.1) 21 (25.0) 26 (31.0) 16085
99 (0.0) 1 (1.2) 1 (1.2) 16086
101 (3.5) 11 (13.1) 7 (8.3) 16087
102 (0.0) 2 (2.4) 0 (0.0) 16088
103 (0.0) 0 (0.0) 1 (1.2) 16089
104 (0.0) 0 (0.0) 1 (1.2) 16090
105 (0.0) 1 (1.2) 2 (2.4) 16091
115 (0.0) 1 (1.2) 0 (0.0) 16097
116 (2.3) 6 (7.1) 5 (6.0) 16098
118 (1.2) 0 (0.0) 0 (0.0) 16100
127 (0.0) 1 (1.2) 1 (1.2) 16109
128 (1.2) 2 (2.4) 1 (1.2) 17000
71 (0.0) 1 (1.2) 0 (0.0) 17064
72 (1.2) 1 (1.2) 0 (0.0) 17065
91 (1.2) 0 (0.0) 0 (0.0) 17079
136 (0.0) 0 (0.0) 1 (1.2) 17117
$display
[1] "n" "prop"
$rtf
name Fn_1 Fprop_1 Fn_2
96 Participants in population 53 <NA> 50
138 with one or more drug-related adverse events 28 (52.8) 41
137 with no drug-related adverse events 25 (47.2) 9
1 <NA> <NA> <NA>
33 Cardiac disorders 4 (7.5) 4
22 Atrial fibrillation 1 (1.9) 0
23 Atrial flutter 0 (0.0) 0
24 Atrioventricular block first degree 1 (1.9) 0
25 Atrioventricular block second degree 0 (0.0) 0
30 Bradycardia 1 (1.9) 0
31 Bundle branch block right 0 (0.0) 0
34 Cardiac failure congestive 1 (1.9) 0
86 Myocardial infarction 2 (3.8) 1
93 Palpitations 0 (0.0) 0
112 Sinus arrhythmia 0 (0.0) 0
113 Sinus bradycardia 2 (3.8) 1
122 Supraventricular extrasystoles 0 (0.0) 1
129 Ventricular extrasystoles 0 (0.0) 1
134 Wolff-parkinson-white syndrome 0 (0.0) 1
40 Congenital, familial and genetic disorders 0 (0.0) 0
130 Ventricular septal defect 0 (0.0) 0
50 Ear and labyrinth disorders 0 (0.0) 2
125 Tinnitus 0 (0.0) 1
131 Vertigo 0 (0.0) 1
57 Eye disorders 0 (0.0) 0
132 Vision blurred 0 (0.0) 0
62 Gastrointestinal disorders 1 (1.9) 6
2 Abdominal pain 0 (0.0) 1
46 Diarrhoea 0 (0.0) 3
48 Dyspepsia 1 (1.9) 0
63 Gastrooesophageal reflux disease 1 (1.9) 0
87 Nausea 0 (0.0) 2
110 Salivary hypersecretion 0 (0.0) 0
120 Stomach discomfort 0 (0.0) 0
133 Vomiting 0 (0.0) 2
64 General disorders and administration site conditions 11 (20.8) 23
5 Application site bleeding 0 (0.0) 1
6 Application site dermatitis 2 (3.8) 5
7 Application site desquamation 0 (0.0) 0
8 Application site discharge 0 (0.0) 0
9 Application site discolouration 0 (0.0) 0
10 Application site erythema 2 (3.8) 5
11 Application site induration 0 (0.0) 0
12 Application site irritation 3 (5.7) 6
13 Application site pain 0 (0.0) 0
14 Application site perspiration 0 (0.0) 0
15 Application site pruritus 4 (7.5) 12
16 Application site reaction 0 (0.0) 0
17 Application site swelling 0 (0.0) 0
18 Application site urticaria 0 (0.0) 0
19 Application site vesicles 0 (0.0) 1
20 Application site warmth 0 (0.0) 1
21 Asthenia 1 (1.9) 0
35 Chest discomfort 0 (0.0) 0
36 Chills 0 (0.0) 0
59 Fatigue 1 (1.9) 1
60 Feeling abnormal 0 (0.0) 0
81 Malaise 0 (0.0) 0
89 Oedema 0 (0.0) 1
90 Oedema peripheral 0 (0.0) 0
92 Pain 0 (0.0) 1
74 Injury, poisoning and procedural complications 0 (0.0) 2
56 Excoriation 0 (0.0) 0
58 Fall 0 (0.0) 1
117 Skin laceration 0 (0.0) 1
135 Wound 0 (0.0) 1
76 Investigations 2 (3.8) 2
28 Blood creatine phosphokinase increased 0 (0.0) 0
29 Body temperature increased 0 (0.0) 1
51 Electrocardiogram st segment depression 1 (1.9) 1
52 Electrocardiogram t wave inversion 0 (0.0) 0
67 Heart rate increased 0 (0.0) 0
68 Heart rate irregular 1 (1.9) 0
82 Metabolism and nutrition disorders 3 (5.7) 0
42 Decreased appetite 1 (1.9) 0
61 Food craving 1 (1.9) 0
73 Increased appetite 1 (1.9) 0
84 Musculoskeletal and connective tissue disorders 0 (0.0) 0
85 Myalgia 0 (0.0) 0
111 Shoulder pain 0 (0.0) 0
88 Nervous system disorders 3 (5.7) 8
26 Balance disorder 0 (0.0) 1
32 Burning sensation 0 (0.0) 0
38 Complex partial seizures 0 (0.0) 1
41 Coordination abnormal 0 (0.0) 1
47 Dizziness 1 (1.9) 3
66 Headache 2 (3.8) 0
70 Hypersomnia 0 (0.0) 0
78 Lethargy 0 (0.0) 0
94 Paraesthesia oral 0 (0.0) 1
95 Parosmia 0 (0.0) 0
119 Somnolence 0 (0.0) 0
121 Stupor 0 (0.0) 0
123 Syncope 0 (0.0) 4
124 Syncope vasovagal 0 (0.0) 0
126 Transient ischaemic attack 0 (0.0) 0
100 Psychiatric disorders 1 (1.9) 6
3 Agitation 0 (0.0) 2
4 Anxiety 0 (0.0) 3
39 Confusional state 0 (0.0) 1
43 Delirium 0 (0.0) 0
44 Depressed mood 0 (0.0) 0
65 Hallucination, visual 0 (0.0) 0
75 Insomnia 0 (0.0) 0
77 Irritability 1 (1.9) 1
79 Libido decreased 0 (0.0) 0
80 Listless 0 (0.0) 0
109 Restlessness 0 (0.0) 0
106 Renal and urinary disorders 0 (0.0) 1
54 Enuresis 0 (0.0) 1
83 Micturition urgency 0 (0.0) 0
107 Reproductive system and breast disorders 1 (1.9) 0
97 Pelvic pain 1 (1.9) 0
108 Respiratory, thoracic and mediastinal disorders 2 (3.8) 0
49 Dyspnoea 1 (1.9) 0
53 Emphysema 1 (1.9) 0
114 Skin and subcutaneous tissue disorders 12 (22.6) 21
27 Blister 0 (0.0) 2
37 Cold sweat 0 (0.0) 0
45 Dermatitis contact 0 (0.0) 0
55 Erythema 6 (11.3) 7
69 Hyperhidrosis 1 (1.9) 1
98 Pruritus 6 (11.3) 12
99 Pruritus generalised 0 (0.0) 0
101 Rash 2 (3.8) 6
102 Rash erythematous 0 (0.0) 1
103 Rash maculo-papular 0 (0.0) 0
104 Rash papular 0 (0.0) 0
105 Rash pruritic 0 (0.0) 1
115 Skin exfoliation 0 (0.0) 1
116 Skin irritation 2 (3.8) 5
118 Skin ulcer 0 (0.0) 0
127 Urticaria 0 (0.0) 0
128 Vascular disorders 0 (0.0) 2
71 Hypertension 0 (0.0) 1
72 Hypotension 0 (0.0) 1
91 Orthostatic hypotension 0 (0.0) 0
136 Wound haemorrhage 0 (0.0) 0
Fprop_2 Fn_3 Fprop_3 Mn_1 Mprop_1 Mn_2 Mprop_2 Mn_3 Mprop_3 Totaln_1
96 <NA> 40 <NA> 33 <NA> 34 <NA> 44 <NA> 86
138 (82.0) 32 (80.0) 16 (48.5) 32 (94.1) 38 (86.4) 44
137 (18.0) 8 (20.0) 17 (51.5) 2 (5.9) 6 (13.6) 42
1 <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA> <NA>
33 (8.0) 4 (10.0) 2 (6.1) 3 (8.8) 0 (0.0) 6
22 (0.0) 2 (5.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
23 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
24 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
25 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
30 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
31 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
34 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
86 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 2
93 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
112 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
113 (2.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 2
122 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
129 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
134 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
40 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
130 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
50 (4.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
125 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
131 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
57 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 0
132 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 0
62 (12.0) 3 (7.5) 3 (9.1) 2 (5.9) 7 (15.9) 4
2 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
46 (6.0) 0 (0.0) 3 (9.1) 0 (0.0) 2 (4.5) 3
48 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 1
63 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
87 (4.0) 2 (5.0) 0 (0.0) 1 (2.9) 1 (2.3) 0
110 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 3 (6.8) 0
120 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
133 (4.0) 0 (0.0) 0 (0.0) 0 (0.0) 3 (6.8) 0
64 (46.0) 17 (42.5) 7 (21.2) 20 (58.8) 18 (40.9) 18
5 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
6 (10.0) 4 (10.0) 3 (9.1) 4 (11.8) 3 (6.8) 5
7 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
8 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
9 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
10 (10.0) 5 (12.5) 1 (3.0) 7 (20.6) 10 (22.7) 3
11 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
12 (12.0) 5 (12.5) 0 (0.0) 3 (8.8) 4 (9.1) 3
13 (0.0) 2 (5.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
14 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (4.5) 0
15 (24.0) 10 (25.0) 2 (6.1) 10 (29.4) 12 (27.3) 6
16 (0.0) 1 (2.5) 1 (3.0) 0 (0.0) 0 (0.0) 1
17 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 1 (2.3) 0
18 (0.0) 1 (2.5) 0 (0.0) 2 (5.9) 0 (0.0) 0
19 (2.0) 3 (7.5) 1 (3.0) 3 (8.8) 3 (6.8) 1
20 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
21 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
35 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
36 (0.0) 0 (0.0) 1 (3.0) 1 (2.9) 0 (0.0) 1
59 (2.0) 4 (10.0) 0 (0.0) 1 (2.9) 0 (0.0) 1
60 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
81 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 1 (2.3) 0
89 (2.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
90 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
92 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
74 (4.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
56 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
58 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
117 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
135 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
76 (4.0) 1 (2.5) 2 (6.1) 0 (0.0) 0 (0.0) 4
28 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
29 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
51 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
52 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
67 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
68 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
82 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 3
42 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 1
61 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
73 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
84 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 1 (2.3) 1
85 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
111 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
88 (16.0) 7 (17.5) 2 (6.1) 4 (11.8) 8 (18.2) 5
26 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
32 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (4.5) 0
38 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
41 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
47 (6.0) 2 (5.0) 1 (3.0) 3 (8.8) 4 (9.1) 2
66 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 2
70 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
78 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 0
94 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
95 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
119 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
121 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
123 (8.0) 2 (5.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
124 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
126 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
100 (12.0) 1 (2.5) 1 (3.0) 3 (8.8) 4 (9.1) 2
3 (4.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
4 (6.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
39 (2.0) 0 (0.0) 1 (3.0) 1 (2.9) 0 (0.0) 1
43 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
44 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
65 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
75 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (4.5) 0
77 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
79 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
80 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
109 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
106 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
54 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
83 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
107 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
97 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
108 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2
49 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
53 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1
114 (42.0) 13 (32.5) 5 (15.2) 18 (52.9) 26 (59.1) 17
27 (4.0) 0 (0.0) 0 (0.0) 3 (8.8) 1 (2.3) 0
37 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
45 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
55 (14.0) 7 (17.5) 3 (9.1) 6 (17.6) 7 (15.9) 9
69 (2.0) 2 (5.0) 0 (0.0) 3 (8.8) 6 (13.6) 1
98 (24.0) 11 (27.5) 1 (3.0) 9 (26.5) 15 (34.1) 7
99 (0.0) 0 (0.0) 0 (0.0) 1 (2.9) 1 (2.3) 0
101 (12.0) 2 (5.0) 1 (3.0) 5 (14.7) 5 (11.4) 3
102 (2.0) 0 (0.0) 0 (0.0) 1 (2.9) 0 (0.0) 0
103 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
104 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (2.3) 0
105 (2.0) 1 (2.5) 0 (0.0) 0 (0.0) 1 (2.3) 0
115 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
116 (10.0) 1 (2.5) 0 (0.0) 1 (2.9) 4 (9.1) 2
118 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
127 (0.0) 1 (2.5) 0 (0.0) 1 (2.9) 0 (0.0) 0
128 (4.0) 1 (2.5) 1 (3.0) 0 (0.0) 0 (0.0) 1
71 (2.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0
72 (2.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
91 (0.0) 0 (0.0) 1 (3.0) 0 (0.0) 0 (0.0) 1
136 (0.0) 1 (2.5) 0 (0.0) 0 (0.0) 0 (0.0) 0
Totalprop_1 Totaln_2 Totalprop_2 Totaln_3 Totalprop_3
96 <NA> 84 <NA> 84 <NA>
138 (51.2) 73 (86.9) 70 (83.3)
137 (48.8) 11 (13.1) 14 (16.7)
1 <NA> <NA> <NA> <NA> <NA>
33 (7.0) 7 (8.3) 4 (4.8)
22 (1.2) 0 (0.0) 2 (2.4)
23 (0.0) 1 (1.2) 0 (0.0)
24 (1.2) 0 (0.0) 0 (0.0)
25 (1.2) 0 (0.0) 0 (0.0)
30 (1.2) 0 (0.0) 0 (0.0)
31 (0.0) 1 (1.2) 0 (0.0)
34 (1.2) 0 (0.0) 0 (0.0)
86 (2.3) 1 (1.2) 1 (1.2)
93 (0.0) 1 (1.2) 0 (0.0)
112 (1.2) 0 (0.0) 0 (0.0)
113 (2.3) 2 (2.4) 0 (0.0)
122 (0.0) 1 (1.2) 1 (1.2)
129 (0.0) 1 (1.2) 0 (0.0)
134 (0.0) 1 (1.2) 0 (0.0)
40 (0.0) 1 (1.2) 0 (0.0)
130 (0.0) 1 (1.2) 0 (0.0)
50 (0.0) 2 (2.4) 1 (1.2)
125 (0.0) 1 (1.2) 0 (0.0)
131 (0.0) 1 (1.2) 1 (1.2)
57 (0.0) 1 (1.2) 1 (1.2)
132 (0.0) 1 (1.2) 1 (1.2)
62 (4.7) 8 (9.5) 10 (11.9)
2 (0.0) 1 (1.2) 1 (1.2)
46 (3.5) 3 (3.6) 2 (2.4)
48 (1.2) 1 (1.2) 0 (0.0)
63 (1.2) 0 (0.0) 0 (0.0)
87 (0.0) 3 (3.6) 3 (3.6)
110 (0.0) 0 (0.0) 3 (3.6)
120 (0.0) 0 (0.0) 1 (1.2)
133 (0.0) 2 (2.4) 3 (3.6)
64 (20.9) 43 (51.2) 35 (41.7)
5 (0.0) 1 (1.2) 0 (0.0)
6 (5.8) 9 (10.7) 7 (8.3)
7 (0.0) 1 (1.2) 0 (0.0)
8 (0.0) 0 (0.0) 1 (1.2)
9 (0.0) 1 (1.2) 0 (0.0)
10 (3.5) 12 (14.3) 15 (17.9)
11 (1.2) 0 (0.0) 0 (0.0)
12 (3.5) 9 (10.7) 9 (10.7)
13 (0.0) 0 (0.0) 2 (2.4)
14 (0.0) 0 (0.0) 2 (2.4)
15 (7.0) 22 (26.2) 22 (26.2)
16 (1.2) 0 (0.0) 1 (1.2)
17 (0.0) 1 (1.2) 2 (2.4)
18 (0.0) 2 (2.4) 1 (1.2)
19 (1.2) 4 (4.8) 6 (7.1)
20 (0.0) 1 (1.2) 0 (0.0)
21 (1.2) 0 (0.0) 0 (0.0)
35 (0.0) 0 (0.0) 1 (1.2)
36 (1.2) 1 (1.2) 0 (0.0)
59 (1.2) 2 (2.4) 4 (4.8)
60 (0.0) 0 (0.0) 1 (1.2)
81 (0.0) 1 (1.2) 1 (1.2)
89 (0.0) 2 (2.4) 0 (0.0)
90 (0.0) 0 (0.0) 1 (1.2)
92 (0.0) 1 (1.2) 1 (1.2)
74 (0.0) 2 (2.4) 1 (1.2)
56 (0.0) 0 (0.0) 1 (1.2)
58 (0.0) 1 (1.2) 0 (0.0)
117 (0.0) 1 (1.2) 0 (0.0)
135 (0.0) 1 (1.2) 0 (0.0)
76 (4.7) 2 (2.4) 1 (1.2)
28 (1.2) 0 (0.0) 0 (0.0)
29 (0.0) 1 (1.2) 0 (0.0)
51 (1.2) 1 (1.2) 0 (0.0)
52 (0.0) 0 (0.0) 1 (1.2)
67 (1.2) 0 (0.0) 0 (0.0)
68 (1.2) 0 (0.0) 0 (0.0)
82 (3.5) 0 (0.0) 1 (1.2)
42 (1.2) 0 (0.0) 1 (1.2)
61 (1.2) 0 (0.0) 0 (0.0)
73 (1.2) 0 (0.0) 0 (0.0)
84 (1.2) 0 (0.0) 1 (1.2)
85 (0.0) 0 (0.0) 1 (1.2)
111 (1.2) 0 (0.0) 0 (0.0)
88 (5.8) 12 (14.3) 15 (17.9)
26 (0.0) 1 (1.2) 0 (0.0)
32 (0.0) 0 (0.0) 2 (2.4)
38 (0.0) 1 (1.2) 0 (0.0)
41 (0.0) 1 (1.2) 0 (0.0)
47 (2.3) 6 (7.1) 6 (7.1)
66 (2.3) 1 (1.2) 1 (1.2)
70 (0.0) 0 (0.0) 1 (1.2)
78 (0.0) 1 (1.2) 1 (1.2)
94 (0.0) 1 (1.2) 0 (0.0)
95 (0.0) 0 (0.0) 1 (1.2)
119 (1.2) 0 (0.0) 0 (0.0)
121 (0.0) 1 (1.2) 0 (0.0)
123 (0.0) 4 (4.8) 3 (3.6)
124 (0.0) 0 (0.0) 1 (1.2)
126 (0.0) 1 (1.2) 0 (0.0)
100 (2.3) 9 (10.7) 5 (6.0)
3 (0.0) 2 (2.4) 0 (0.0)
4 (0.0) 3 (3.6) 0 (0.0)
39 (1.2) 2 (2.4) 0 (0.0)
43 (0.0) 0 (0.0) 1 (1.2)
44 (0.0) 1 (1.2) 0 (0.0)
65 (0.0) 0 (0.0) 1 (1.2)
75 (0.0) 0 (0.0) 2 (2.4)
77 (1.2) 1 (1.2) 0 (0.0)
79 (0.0) 0 (0.0) 1 (1.2)
80 (0.0) 0 (0.0) 1 (1.2)
109 (0.0) 1 (1.2) 0 (0.0)
106 (0.0) 1 (1.2) 1 (1.2)
54 (0.0) 1 (1.2) 0 (0.0)
83 (0.0) 0 (0.0) 1 (1.2)
107 (1.2) 0 (0.0) 0 (0.0)
97 (1.2) 0 (0.0) 0 (0.0)
108 (2.3) 0 (0.0) 0 (0.0)
49 (1.2) 0 (0.0) 0 (0.0)
53 (1.2) 0 (0.0) 0 (0.0)
114 (19.8) 39 (46.4) 39 (46.4)
27 (0.0) 5 (6.0) 1 (1.2)
37 (1.2) 0 (0.0) 0 (0.0)
45 (0.0) 1 (1.2) 0 (0.0)
55 (10.5) 13 (15.5) 14 (16.7)
69 (1.2) 4 (4.8) 8 (9.5)
98 (8.1) 21 (25.0) 26 (31.0)
99 (0.0) 1 (1.2) 1 (1.2)
101 (3.5) 11 (13.1) 7 (8.3)
102 (0.0) 2 (2.4) 0 (0.0)
103 (0.0) 0 (0.0) 1 (1.2)
104 (0.0) 0 (0.0) 1 (1.2)
105 (0.0) 1 (1.2) 2 (2.4)
115 (0.0) 1 (1.2) 0 (0.0)
116 (2.3) 6 (7.1) 5 (6.0)
118 (1.2) 0 (0.0) 0 (0.0)
127 (0.0) 1 (1.2) 1 (1.2)
128 (1.2) 2 (2.4) 1 (1.2)
71 (0.0) 1 (1.2) 0 (0.0)
72 (1.2) 1 (1.2) 0 (0.0)
91 (1.2) 0 (0.0) 0 (0.0)
136 (0.0) 0 (0.0) 1 (1.2)
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