obs2lia: Convert observed heritability to the liability scale
In PDRohde/ugnome: Utility Functions for Genomic Analyses
Description
Usage
Arguments
Author(s)
Description
Whether the estiamted heritability is based on GREML or on summary statistics, if the trait is a disease trait,
the estimate may be biased due to assertainment bias. To account for this, one can convert the observed heritability
to the heritability on the liability scale by correcting for population disease prevalence and the proportion of cases in the sample
Usage
1
Arguments
h2
observed SNP heritability
K
Population disease prevalence
P
Proportion of cases in the sample
Author(s)
Palle Duun Rohde
PDRohde/ugnome documentation built on Aug. 30, 2021, 7:47 p.m.
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Description Usage Arguments Author(s)
Description
Whether the estiamted heritability is based on GREML or on summary statistics, if the trait is a disease trait, the estimate may be biased due to assertainment bias. To account for this, one can convert the observed heritability to the heritability on the liability scale by correcting for population disease prevalence and the proportion of cases in the sample
Usage
1 |
Arguments
h2 |
observed SNP heritability |
K |
Population disease prevalence |
P |
Proportion of cases in the sample |
Author(s)
Palle Duun Rohde
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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